scholarly journals Nigella sativa (Kalonji): A Black Seed of Miracle

2021 ◽  
Vol 8 (4) ◽  
pp. 342-357
Author(s):  
Shifali Thakur ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Nigella Sativa ◽  
Chemical Constituents ◽  
Acne Vulgaris ◽  
World Health ◽  
Pharmacological Properties ◽  
Gulf Region ◽  
Medicinal Uses ◽  
Black Cumin ◽  
Black Seed ◽  
Wide Range

It is recommended by the World health organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa is commonly known as a Black seed, Black cumin or 'Habbatul Barakah' i.e. an annual herb possessing a wide range of medicinal uses apart from its commercial significance as a spice yielding plant. It has long been used in the folk medicine system of the Arabian Gulf region, Far East Asia, and Europe. Seeds and oils of N. Sativa are the primary medicinal source from ancient times. It is one of the most common herbal plants used worldwide and possesses various chemical constituents such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellicine, nigllimine, nigellidine, and alpha-hederin. There are more than 100 constituents isolated from the plant. These chemical compounds have many pharmacological activities such as antibacterial, antiviral, anti-inflammatory, wound healing effect and also for acne vulgaris, skin cancer, pigmentation and many other cosmeceutical properties. Much scientific research on N. sativa has been conducted over the last five decades to investigate chemical and pharmacological properties. In this review, the phytochemicals, pharmacological properties, Ayurvedic properties and folk uses of Nigella sativa are briefly explained. Keywords: Nigella sativa, Kalonji, Antinephrotic, Immunomodulary, Black cumin.

scholarly journals A Review on the Cosmeceutical and External Applications ofNigella sativa

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmad M. Eid ◽  
Nagib A. Elmarzugi ◽  
Laila M. Abu Ayyash ◽  
Maher N. Sawafta ◽  
Hadeel I. Daana
Keyword(s):  
Health Care ◽  
Wound Healing ◽  
Nigella Sativa ◽  
Chemical Constituents ◽  
Acne Vulgaris ◽  
World Health ◽  
Pharmacological Effects ◽  
The World ◽  
Wound Healing Effect ◽  
Health Organization

It is estimated by the World Health Organization (WHO) that most of the world’s population depends on herbal medicine for their health care.Nigella sativa (N. sativa),also known as black-caraway and as “Kalonji,” is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and also for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. Based on the folklore usage ofN. sativaseeds and oil, they are used in various systems of food and medicines. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications ofN. sativawhich is expected to stimulate further studies on this subject.

scholarly journals An Overview on Composition and Therapeutic Potentials of the Black Seed (Nigella sativa)

2021 ◽  
Vol 9 (12) ◽  
pp. 1966-1975
Author(s):  
Yusra Tafheem S
Keyword(s):  
Nigella Sativa ◽  
Herbal Medicines ◽  
Extended Period ◽  
Herbaceous Plant ◽  
Medical Systems ◽  
Active Constituent ◽  
Black Cumin ◽  
Toxicological Effects ◽  
Black Seed ◽  
Wide Range

Abstract: Nigella sativa is an annual herbaceous plant that belongs to the Ranunculaceae family and produces seeds known as black seed or black cumin. Black seed has been used in various civilization around the world for centuries to treat various ailments. It is widely used in a variety of traditional medical systems, including Unani, Ayurveda, and Siddha. Black seed is considered to be nutritionally dense, with high levels of fat, protein, dietary fibre, calcium, and iron. The seed is known to have a wide range of pharmacological properties which are supported by numerous studies. Extensive research has been carried out over decades to confirm the seed’s anti-oxidant, anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, antilipidemic, anti-cancer, gastroprotective, hepatoprotective, neuroprotective properties etc. Black seed has earned a position among the top ranked evidence-based herbal medicines due to its marvellous healing properties. Studies have revealed that the presence of thymoquinone, a major bioactive component of the seed essential oil, is responsible for the majority of its therapeutic properties. Consumption of the seeds for an extended period of time has been shown to have significant effects on lowering blood glucose levels, improving lipid profiles, and other biochemical parameters. The minor or negligible toxicological effects of black seed and its active constituent, thymoquinone, support its long-term use in traditional food and medicine. Because of their low toxicity, black seed is frequently used in food as a flavouring agent, additive in breads, and pickles. The current review summarises the composition, important pharmacological studies, dosage and toxicity of the Blackseed and its application in food industry.

Therapeutic perspectives of the black cumin component thymoquinone: A review

2021 ◽  
Author(s):  
Chandan Sarkar ◽  
Sarmin Jamaddar ◽  
Tawhida Islam ◽  
Milon Mondal ◽  
Muhammad Torequl Islam ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Nigella Sativa ◽  
Pharmacological Properties ◽  
Black Cumin

The dietary phytochemical thymoquinone, obtained from the black and angular seeds of Nigella sativa, is a promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties.

scholarly journals An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties

2021 ◽  
Vol 25 ◽  
pp. 100404 ◽  
Author(s):  
Md Faruque Ahmad ◽  
Fakhruddin Ali Ahmad ◽  
Syed Amir Ashraf ◽  
Hisham H. Saad ◽  
Shadma Wahab ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Pharmacological Properties ◽  
Black Seed ◽  
Phytochemical Constituents

scholarly journals Targeting microRNAs with thymoquinone: a new approach for cancer therapy

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Mina Homayoonfal ◽  
Zatollah Asemi ◽  
Bahman Yousefi
Keyword(s):  
Gene Expression ◽  
Cancer Therapy ◽  
Molecular Mechanisms ◽  
World Health ◽  
Therapeutic Effects ◽  
Black Cumin ◽  
Small Noncoding Rnas ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancer Agent

AbstractCancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recently, bioactive natural compounds have been widely recognized due to their therapeutic effects for treatment of various chronic disorders, notably cancer. Thymoquinone (TQ), the most valuable constituent of black cumin seeds, has shown anti-cancer characteristics in a wide range of animal models. The revolutionary findings have revealed TQ’s ability to regulate microRNA (miRNA) expression, offering a promising approach for cancer therapy. MiRNAs are small noncoding RNAs that modulate gene expression by means of variation in features of mRNA. MiRNAs manage several biological processes including gene expression and cellular signaling pathways. Accordingly, miRNAs can be considered as hallmarks for cancer diagnosis, prognosis and therapy. The purpose of this study was to review the various molecular mechanisms by which TQ exerts its potential as an anti-cancer agent through modulating miRNAs.

scholarly journals review of black seed extract as an agent in the wound healing process

2021 ◽  
Vol 1 (2) ◽  
pp. 87-96
Author(s):  
Muhammad Hakeem Mohd Zaid ◽  
Muhammad Faezuddin Hanafi ◽  
Muhammad Salahuddin Haris
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Microscopic Analysis ◽  
Seed Extract ◽  
Flowering Plant ◽  
Wound Healing Process ◽  
Black Cumin ◽  
Black Seed

Introduction: Nigella Sativa or Black Cumin is an annual flowering plant that can be used for wound treatment. In the treatment for wound healing, this plant contains many beneficial components that can help with the treatment but this plant utilisation in the medical field is still limited. This review will provide an overview of the advantages when this plant is used in the wound healing treatment. Method: The review was based on the ROSES protocol, and the databases used were ScienceDirect, PubMed, and Google Scholar. After the search, only 11 papers had been chosen to be included in the results and they were divided into four main themes that were used for the analysis of the results. Results: The themes were gross analysis, microscopic analysis, biochemical analysis and antimicrobial analysis. Conclusion: In conclusion, the black seed extract contains several valuable properties, such as antimicrobial and antioxidant properties, which help improve the wound healing process. Further study needs to be done to discover more potential of Nigella Sativa in treating the wound.

scholarly journals Comparison of Chemical Constituents of Essential Oils of Black Cumin (Nigella sativa L.)

2013 ◽  
Vol 25 (18) ◽  
pp. 10407-10409 ◽  
Author(s):  
Fahad Al Juhaimi ◽  
Gilles Figueredo ◽  
Mehmet Musa Özcan ◽  
Pierre Chalard
Keyword(s):  
Essential Oils ◽  
Nigella Sativa ◽  
Chemical Constituents ◽  
Black Cumin

scholarly journals Black cumin Potential Anticancer effect of Black Cumin seed (Nigella sativa L.) extracts as determined by Cytotoxicity test against Larvae of Artemia salina Leach using Brine Shrimp Lethality Test (BSLT)

2020 ◽  
Vol 13 (2) ◽  
pp. 25-29
Author(s):  
Rasidah ◽  
Vonna Aulianshah
Keyword(s):  
Brine Shrimp ◽  
Cytotoxic Effect ◽  
Nigella Sativa ◽  
Artemia Salina ◽  
Cytotoxicity Test ◽  
Black Cumin ◽  
Black Seed ◽  
Black Cumin Seed ◽  
Seed Extracts ◽  
Cumin Seed

Black cumin plant seed or black seed (Nigella sativa L.) is among the most commonly used spices. This plant is grown mostly for its spicy seeds. Studies have reported that black cumin seeds have high levels of antioxidant that correlates with anticancer activities. The current study aims to determine the cytotoxic effect of black seed extracts on brine shrimp larvae (Artemia salina Leach) using Brine Shrimp Lethality Test (BSLT). Black cumin seed extract was obtained through percolation method using an extraction solvent (ethanol 96%). The cytotoxicity test was performed at 0 ppm concentration (control) and 10, 50, 100, 250 and 500 ppm concentrations of black seed extracts. We use 10 Brine Shrimp larvae per tube and repeated the test three times for each test group. Our results show that ethanolic extract (90%) of black cumin seeds (Nigella sativa L.) has a strong cytotoxic effect on Artemia salina larvae with the LC50 value of 107.2 ppm.

scholarly journals Shatavari (Asparagus Racemosus) - The Best Female Reproductive Tonic

2021 ◽  
Vol 8 (5) ◽  
pp. 73-84
Author(s):  
Shifali Thakur ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
World Health ◽  
Asparagus Racemosus ◽  
Pharmacological Properties ◽  
General Description ◽  
Wound Healing Effect ◽  
Ancient Times ◽  
Health Organization ◽  
Herbal Plant

It is recommended by the World health organization (WHO) the most of the world’s population depends on herbal medicine for their health care. Shatavari, Asparagus racemosus is one of the most significant restorative plant employed by Ayurvedic Vaidyas from ancient times. This herbal plant has wide selection of biological activities and described as a Rasayan in Ayurvedic literatures. Root is the most used part of Shatavari by Ayurvedic Vaidyas. It is one of the most common herbal plant used worldwide and possess various chemical constituents such as Racemoside A, B, C, Shatavarins, Asparanin A, Immunoside, 27 α-dimethyl-1β, 2β,3β-trihydroxy-25-spirost-4-en-19β-oic, 27 α-dimethyl-1β, 2β,3β-trihydroxy-25-spirost-4-en-19β-oic and many others. It is described as a tonic and have lactogenic properties. It has an extensive use in Nervine disorders, Acid peptic diseases, several contagious ailments and as a immunomodulant. It is primarily used in female ailments mainly as galactagogic and several menstrual problems. The chemical constituents of Asparagus racemosus have many pharmacological activities such as antibacterial, antiviral, anti-inflammatory, wound healing effect, antidepressant, anti-anxiety, antifertility and also skin cancer, pigmentation and many other. Much scientific research on Asparagus racemosus has been conducted over the last years to investigate chemical and pharmacological properties. In this review, the general description, phytochemicals, pharmacological properties, ayurvedic properties and folk uses of Asparagus racemosus are briefly explained. Keywords: Shatavari, Ayurveda, Saponins, Menstrual disorders, Anti-ulcer, Immunomodulatory.

scholarly journals Determination of chemical composition of local black seeds Nigella sativa L

2007 ◽  
Vol 4 (2) ◽  
pp. 244-247
Author(s):  
Baghdad Science Journal
Keyword(s):  
Fatty Acids ◽  
Chemical Composition ◽  
Nigella Sativa ◽  
Mineral Element ◽  
Black Cumin ◽  
Black Seed ◽  
Cobalt Nickel ◽  
Black Seeds ◽  
Seed Calcium

Chemical analysis for evaluation of Nigella sativa L. (black cumin) seeds showed a composition of Fat 39% ; Protein 28% ; Carbohydrate 21% ; Moisture 6% and Ash 4.5% . It was found that the black seed contains the following mineral element : Magnesium 0.26 gm /100gm seed ; Calcium 0.25 gm /100gm seed and Iron 25 ?g / gm /100gm seed ; zinc 4.51?g /gm /100gm seed and Copper 3.60 ?g /gm /100gm seed. The analysis also showed that mineral element I. e. ; lead ; Cobalt ; Nickel ; Chrom ; Cadmium and Aresenic are not present . It was found that the fat of the black seed contains the following fatty acids : Myristic 2.8%; Palmtic 16.6%; Stearic 0.8 % ; Oleic 13.79% ; Linoleic 64.2% and Arachidic 1.9% .

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