Multifunctional nanoparticles as somatostatin receptor-targeting delivery system of polyaniline and methotrexate for combined chemo–photothermal therapy

2018 ◽  
Vol 68 ◽  
pp. 154-167 ◽  
Author(s):  
Hanh Thuy Nguyen ◽  
Cao Dai Phung ◽  
Raj Kumar Thapa ◽  
Tung Thanh Pham ◽  
Tuan Hiep Tran ◽  
...  
Keyword(s):  
Delivery System ◽  
Photothermal Therapy ◽  
Somatostatin Receptor ◽  
Multifunctional Nanoparticles ◽  
Receptor Targeting ◽  
Targeting Delivery

One-step synthesis of multifunctional nanoparticles for CT/PA imaging guided breast cancer photothermal therapy

2021 ◽  
Vol 201 ◽  
pp. 111630
Author(s):  
Liwen Fu ◽  
Shuguang Yang ◽  
Shichao Jiang ◽  
Xiaojun Zhou ◽  
Zhou Sha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photothermal Therapy ◽  
Multifunctional Nanoparticles ◽  
One Step

Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Interest ◽  
Upconversion Nanoparticles ◽  
Multifunctional Nanoparticles ◽  
Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

scholarly journals Erratum to: Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F–DOPA

2017 ◽  
Vol 44 (12) ◽  
pp. 2150-2151 ◽  
Author(s):  
Murat Fani Bozkurt ◽  
Irene Virgolini ◽  
Sona Balogova ◽  
Mohsen Beheshti ◽  
Domenico Rubello ◽  
...  
Keyword(s):  
Somatostatin Receptor ◽  
Ct Imaging ◽  
Neuroendocrine Neoplasms ◽  
Receptor Targeting ◽  
Pet Ct

Corrigendum to “Designing an immunocyte-targeting delivery system by use of beta-glucan” [Vaccine 36 (2018) 186–189]

Vaccine ◽  
2018 ◽  
Vol 36 (45) ◽  
pp. 6892
Author(s):  
Noriko Miyamoto ◽  
Shinichi Mochizuki ◽  
Kouji Kobiyama ◽  
Ken J. Ishii ◽  
Kazuo Sakurai
Keyword(s):  
Delivery System ◽  
Beta Glucan ◽  
Targeting Delivery

scholarly journals Self-Assembled Tetrahedral Framework Nucleic Acid Mediated Tumor-Associated Macrophages Reprogramming and Enhancing Cancer Immunotherapy

2021 ◽  
Author(s):  
husun qian ◽  
Yixin Fu ◽  
Minkang Guo ◽  
Wu Yang ◽  
Dian Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Delivery System ◽  
Signal Pathways ◽  
Tumor Associated Macrophages ◽  
Tetrahedral Framework ◽  
Immunomodulatory Agents ◽  
Cpg Odns ◽  
Targeting Delivery ◽  
M1 Phenotype ◽  
Self Assembled

Abstract There is increasing interest in depleting or repolarizing tumor-associated macrophages (TAMs) to generate a pro-inflammatory effect. However, TAMs usually display an immunosuppressive M2-like phenotype in tumor microenvironment. Apparently, developing a macrophage targeting delivery system with immunomodulatory agents is urgent. In the study, an efficient siRNAs and CpG ODNs delivery system (CpG-siRNA-tFNA) was prepared with nucleic acid stepwise self-assembled. The tFNA composed of CpG ODNs and siRNAs showed a higher stability and an enhanced cellular uptake efficiency. Moreover, the CpG-siRNA-tFNA effectively reprogrammed TAMs toward M1 phenotype polarization with increased pro-inflammatory cytokines secretion and NF-κB signal pathways activation, which triggers dramatical antitumor immune responses. Hence, we have developed an efficient and reliable TAM-targeted therapeutic with immunomodulatory agents for for clinical applications.

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

A multifunctional near-infrared laser-triggered drug delivery system using folic acid conjugated chitosan oligosaccharide encapsulated gold nanorods for targeted chemo-photothermal therapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3811-3825 ◽  
Author(s):  
Panchanathan Manivasagan ◽  
Seung Won Jun ◽  
Van Tu Nguyen ◽  
Nguyen Thanh Phong Truong ◽  
Giang Hoang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Combination Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Laser ◽  
Chitosan Oligosaccharide

FA–COS–TGA–GNRs–DOX have been successfully designed as a drug delivery system for chemo-photothermal combination therapy.

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