Two weeks of moderate intensity locomotor training increased corticosterone concentrations but did not alter the number of adropin-immunoreactive cells in the hippocampus of diabetic type 2 and control rats

<P>Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. </P><P> Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI). Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP. Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005). Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.</P>

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Epidemiology of Hypertension and Diabetes Mellitus in Latin America

Current Hypertension Reviews ◽

10.2174/1573402116999200917152952 ◽

2020 ◽

Vol 16 ◽

Author(s):

Patricio Lopez-Jaramillo ◽

Jose Lopez-Lopez ◽

Daniel Cohen ◽

Natalia Alarcon-Ariza ◽

Margarita Mogollon-Zehr

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Latin America ◽

Cardiovascular Diseases ◽

Latin American ◽

Premature Mortality ◽

Increased Risk ◽

And Control

: Hypertension and type 2 diabetes mellitus are two important risk factors that contribute to cardiovascular diseases worldwide. In Latin America hypertension prevalence varies from 30 to 50%. Moreover, the proportion of awareness, treatment and control of hypertension is very low. The prevalence of type 2 diabetes mellitus varies from 8 to 13% and near to 40% are unaware of their condition. In addition, the prevalence of prediabetes varies from 6 to 14% and this condition has been also associated with increased risk of cardiovascular diseases. The principal factors linked to a higher risk of hypertension in Latin America are increased adiposity, low muscle strength, unhealthy diet, low physical activity and low education. Besides being chronic conditions, leading causes of cardiovascular mortality, both hypertension and type 2 diabetes mellitus represent a substantial cost for the weak health systems of Latin American countries. Therefore, is necessary to implement and reinforce public health programs to improve awareness, treatment and control of hypertension and type 2 diabetes mellitus, in order to reach the mandate of the Unit Nations of decrease the premature mortality for CVD.

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PROBABILIDAD DE ÉXITO DE LAS TELECONSULTAS PARA EL CUIDADO DE PACIENTES DIABÉTICOS CON DEPRESIÓN

Revista TECNIA ◽

10.21754/tecnia-250215.04 ◽

2016 ◽

Vol 26 (1) ◽

pp. 23

Author(s):

Huber Nieto Chaupis

Keyword(s):

Diabetes Mellitus ◽

Diabetes Mellitus Type 2 ◽

Diabetes Mellitus Type ◽

Depression Treatment ◽

Additional Mechanism ◽

Electronic Health ◽

And Control ◽

Depressive Episodes

RESUMENEn este documento se presenta un estudio sobre el impacto de los parámetros elegidos en varios escenarios de la telemedicina y cómo estos pueden jugar un rol crucial para llevar a cabo una eficiente teleconsulta. Tomamos el ejemplo cuando la Telemedicina podría ser un mecanismo adicional dentro del marco de salud electrónica (eHealth en inglés) en la cual el paciente podría aspirar a mejorar y controlar sus enfermedades, como por ejemplo aquellos que han sido diagnosticados con diabetes Mellitus tipo-2 y que viven en zonas periféricas de la ciudad de Lima. Además, éstos pacientes sufrirían adicionalmente de episodios depresivos. Hemos realizado una encuesta cuya estadística resultante entra en un formalismo matemático basado en probabilidades de éxito y que por el cual lo hemos evaluado para varios escenarios con diferentes eficiencias que han sido construidas con los parámetros de la Telemedicina. Hemos encontrado que cuando el paciente adiciona las teleconsultas en su tratamiento de diabetes y depresión, su recuperación en cuanto a estabilizar su glucosa y detener la depresión podría tomar 15 ±3 días subsecuentemente al 5to día de inicio de las teleconsultas.Palabras clave.- Telemedicina, Diabetes Mellitus tipo 2.ABSTRACTTelemedicine scenarios and how those can play a main rol as efficient consultations. We take Telemedicine as example that could be an additional mechanism within the frame of electronic health (eHealth) in which one the patient could improve his health and control his illness, for instance those who have been diagnosed with diabetes Mellitus type-2 and who lives in peripherical zones of Lima city. Further, those patients suffer additional depressive episodes. We made an inquiry, and its results throw a mathemathical formalism based on probabilities of success and for which we have evaluated several scenarios with different efficiencies that have been built by the Telemedcine facings. We have found that when the patient adds these consultations to his or her diabetes and depression treatment, recovery, as to glucose stabilization and stopping depression might take 15 ±3 days subsequently on the 5th day since the beginning of these consultations.Key words.- Telemedicina, Diabetes Mellitus tipo 2.

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Recovery of 0.1Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS)

Medical Engineering & Physics ◽

10.1016/j.medengphy.2010.02.004 ◽

2010 ◽

Vol 32 (4) ◽

pp. 407-413 ◽

Cited By ~ 13

Author(s):

L. Bocchi ◽

A. Evangelisti ◽

M. Barrella ◽

L. Scatizzi ◽

M. Bevilacqua

Keyword(s):

Blood Flow ◽

Skin Blood Flow ◽

Diabetic Type ◽

Electrical Modulation

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Acute and Chronic Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Glycemic Control and Body Composition in Older Women with Type 2 Diabetes

Obesities ◽

10.3390/obesities1020007 ◽

2021 ◽

Vol 1 (2) ◽

pp. 72-87

Author(s):

Alexis Marcotte-Chénard ◽

Dominic Tremblay ◽

Marie-Michelle Mony ◽

Pierre Boulay ◽

Martin Brochu ◽

...

Keyword(s):

Body Composition ◽

Older Women ◽

Interval Training ◽

Moderate Intensity ◽

Continuous Training ◽

Glucose Levels ◽

Mild Hyperglycemia ◽

Low Volume ◽

High Intensity Interval

Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). Methods: Thirty older women (68 ± 5 years) with T2D were randomized in two groups—HIIT (75 min/week) or MICT (150 min/week). Glucose homeostasis (A1c, glucose, insulin, HOMA-IR2) and body composition (iDXA) were measured before and after the 12-week exercise intervention. During the first and last week of training (24-h before and 48-h after exercise), the following CGM-derived data were measured: 24-h and peak glucose levels, glucose variability and time spent in hypoglycemia as well as severe and mild hyperglycemia. Results: While lean body mass increased (p = 0.035), total and trunk fat mass decreased (p ≤ 0.007), without any difference between groups (p ≥ 0.81). Fasting glucose levels (p = 0.001) and A1c (p = 0.014) significantly improved in MICT only, with a significant difference between groups for fasting glucose (p = 0.02). Neither HIIT nor MICT impacted CGM-derived data at week 1 (p ≥ 0.25). However, 24-h and peak glucose levels, as well as time spent in mild hyperglycemia, decreased in HIIT at week 12 (p ≤ 0.03). Conclusion: These results suggest that 12 weeks of low-volume HIIT is enough to provide similar benefit to MICT for body composition and improve the acute effect of exercise when measured with CGM.

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Ayurveda Body–Mind Constitutional Types and Role of Yoga Intervention Among Type 2 Diabetes Mellitus Population of Chandigarh and Panchkula Regions

Annals of Neurosciences ◽

10.1177/09727531211000040 ◽

2021 ◽

pp. 097275312110000

Author(s):

Madhava Sai Sivapuram ◽

Vinod Srivastava ◽

Navneet Kaur ◽

Akshay Anand ◽

Raghuram Nagarathna ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Lipid Profiles ◽

Control Groups ◽

Yoga Intervention ◽

Positive Effects ◽

Study Results ◽

Significant Difference ◽

And Control

Background: Type 2 diabetes needs a better understanding of etiological factors and management strategies based on lifestyle and constitutional factors, given its high association rate with many cardiovascular, neurological disorders, and COVID-19 infection. Purpose: The present study was undertaken to investigate the effect of Diabetes-specific integrated Yoga lifestyle Protocol (DYP) on glycemic control and lipid profiles of diabetic adults. Along with the DYP intervention, the individuals residing in Chandigarh and Panchkula union territories in the northern part of India were assessed for Ayurveda-based body–mind constitutional type. Ayurveda describes body–mind constitution as “ prakriti,” which has been discussed from two angles, namely physiological and psychological as body and mind are correlated. Methods: Cluster sampling of waitlist control study subjects was used as the sampling method for the study. A total of 1,215 registered subjects (81 diabetic) responded in randomly selected clusters in Chandigarh and Panchkula. Ayurveda physicians did Ayurveda body–mind constitutional assessment called prakriti assessment (physiological body–mind constitution assessment) in 35 participants (23 diabetic, 12 prediabetic) as a part of the study. Results: A group of 50 subjects was randomly selected for yoga intervention out of 81 diabetes mellitus adults, and 31 subjects were enrolled as waitlist controls. A significant decrease in the glycosylated hemoglobin levels from 8.49 ± 1.94% to 7.97 ± 2.20% in the intervention group was noticed. The lipid profiles of the DYP intervention and control groups were monitored. Three-month follow-up results of lipid profile diagnostic tests in intervention and control groups showed a significant difference between the two groups ( P < 0.05). Most diabetic and prediabetic individuals were found to have pitta dosha ( pitta controls all heat, metabolism, and transformation in the mind and body) as dominant constitution type. Conclusion: The study results demonstrated significant positive effects of yoga in diabetic individuals. This study has indicated the evidence for the safety and efficacy of the validated DYP for community-level interventions to prevent maladies like brain damage and stroke.

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