Heterozygous Polymorphism in Bardet-Biedl Syndrome (BBS) Genes was Associated with Early Onset Morbid Obesity, Metabolic Syndrome and Low Leptin Levels

2020 ◽  
Vol 229 ◽  
pp. 161-162
Author(s):  
Neveen Asaad ◽  
Egor Volcotrub ◽  
Amrit Bhangoo ◽  
Svetlana Ten
Keyword(s):  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Early Onset ◽  
Bardet Biedl Syndrome

Serum Retinol and β-carotene Levels and Risk Factors for Cardiovascular Disease in Morbid Obesity

2010 ◽  
Vol 80 (3) ◽  
pp. 159-167 ◽  
Author(s):  
Gabriela Villaça Chaves ◽  
Gisele Gonçalves de Souza ◽  
Andréa Cardoso de Matos ◽  
Dra. Wilza Abrantes Peres ◽  
Silvia Elaine Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Serum Levels ◽  
World Health ◽  
Morbidly Obese ◽  
Serum Retinol ◽  
Significant Difference ◽  
Β Carotene

Objective: To evaluate retinol and β-carotene serum levels and their relationship with risk factors for cardiovascular disease in individuals with morbid obesity, resident in Rio de Janeiro. Methodology: Blood serum concentrations of retinol and β-carotene of 189 morbidly obese individuals were assessed. The metabolic syndrome was identified according to the criteria of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO). Lipid profile, insulin resistance, basal insulin, glycemia, blood pressure, and anthropometry and their correlation with retinol and β-carotene serum levels were evaluated. Results: Metabolic syndrome diagnosis was observed in 49.0% of the sample. Within this percentage the levels of β-carotene were significantly lower when body mass index increased. Serum retinol didn't show this behavior. Serum retinol inadequacy in patients with metabolic syndrome (61.3%), according to WHO criterion, was higher (15.8%) than when the whole sample was considered (12.7%). When metabolic syndrome was diagnosed by NCEP criterion, β-carotene inadequacy was higher (42.8%) when compared to the total sample (37.5%). There was a significant difference between average β-carotene values of patients with and without metabolic syndrome (p=0.048) according to the classification of the NCEP. Lower values were found in patients with metabolic syndrome. Conclusion: Considering the vitamin A contribution in antioxidant protection, especially when risk factors for cardiovascular disease are present, it is suggested that great attention be given to morbidly obese. This could aid in prevention and treatment of cardiovascular disease, which affects a significant part of the population.

scholarly journals Plasma Proteome Profiles Associated with Diet-Induced Metabolic Syndrome and the Early Onset of Metabolic Syndrome in a Pig Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73087 ◽  
Author(s):  
Marinus F. W. te Pas ◽  
Sietse-Jan Koopmans ◽  
Leo Kruijt ◽  
Mario P. L. Calus ◽  
Mari A. Smits
Keyword(s):  
Metabolic Syndrome ◽  
Early Onset ◽  
Pig Model ◽  
Plasma Proteome

Complement C3 as a predictor for metabolic syndrome in morbid obesity

2017 ◽  
Vol 263 ◽  
pp. e200-e201
Author(s):  
Stefanie Van Mil ◽  
Ulas Biter ◽  
Gert-Jan Van De Geijn ◽  
Guido Mannaerts ◽  
Manuel Castro Cabezas
Keyword(s):  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Complement C3

scholarly journals The Endocrine and Metabolic Characteristics of a Large Bardet-Biedl Syndrome Clinic Population

2018 ◽  
Vol 103 (5) ◽  
pp. 1834-1841 ◽  
Author(s):  
Safa Mujahid ◽  
Katharine F Hunt ◽  
Yee S Cheah ◽  
Elizabeth Forsythe ◽  
Jonathan M Hazlehurst ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Subclinical Hypothyroidism ◽  
Matched Control ◽  
Genetic Diagnosis ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Bardet Biedl Syndrome ◽  
Metabolic Characteristics ◽  
Control Subjects ◽  
The Metabolic Syndrome

Abstract Context Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder in which previous reports have described obesity and a metabolic syndrome. Objective We describe the endocrine and metabolic characteristics of a large BBS population compared with matched control subjects. Design We performed a case-control study. Setting This study was performed at a hospital clinic. Patients Study patients had a clinical or genetic diagnosis of BBS. Main Outcome Measurements Our study determined the prevalence of a metabolic syndrome in our cohort. Results A total of 152 subjects were studied. Eighty-four (55.3%) were male. Mean (± standard deviation) age was 33.2 ± 1.0 years. Compared with age-, sex-, and body mass index–matched control subjects, fasting glucose and insulin levels were significantly higher in subjects with BBS (glucose: BBS, 5.2 ± 1.2 mmol/L vs control, 4.9 ± 0.9 mmol/L, P = 0.04; insulin: BBS, 24.2 ± 17.0 pmol/L vs control, 14.2 ± 14.8 pmol/L, P < 0.001). Serum triglycerides were significantly higher in subjects with BBS (2.0 ± 1.2 mmol/L) compared with control subjects (1.3 ± 0.8 mmol/L; P < 0.001), but total cholesterol, high-density lipoprotein, and low-density lipoprotein were similar in both groups. Systolic blood pressure was higher in the BBS group (BBS, 135 ± 18 mm Hg vs control subjects, 129 ± 16 mm Hg; P = 0.02). Alanine transaminase was raised in 34 (26.8%) subjects with BBS, compared with five (8.9%) control subjects (P = 0.01). The rate of metabolic syndrome, determined using International Diabetes Federation criteria, was significantly higher in the BBS group (54.3%) compared with control subjects (26% P < 0.001). Twenty-six (19.5%) of male subjects with BBS were hypogonadal (serum testosterone, 9.9 ± 5.3 mmol/L), but significant pituitary abnormalities were uncommon. Subclinical hypothyroidism was present in 24 of 125 (19.4%) patients with BBS, compared with 3 of 65 (4.6%) control subjects (P = 0.01). Conclusions Insulin resistance and the metabolic syndrome are increased in adult patients with BBS compared with matched control subjects. Increased subclinical hypothyroidism in the BBS cohort needs further investigation.

A NovelADIPOQMutation (p.M40K) Results in Impaired High-Molecular-Weight Adiponectin and Associates with Obesity and Early-Onset Metabolic Syndrome

2011 ◽  
pp. OR38-4-OR38-4
Author(s):  
Ana Carolina Bueno ◽  
Margaret Castro ◽  
Jorge Elias Junior ◽  
Viviane Cunha Cardoso ◽  
Marco Antonio Barbieri ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Early Onset ◽  
High Molecular Weight Adiponectin

scholarly journals Bariatric Surgery in Adults: Patient Workup and Preparation

2020 ◽  
pp. 8-14
Author(s):  
Ravi Kant ◽  
Shankar Roy ◽  
Pradeep Yadav KL ◽  
Monika Pathania
Keyword(s):  
Risk Factors ◽  
Metabolic Disease ◽  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Life Style ◽  
Point Of View ◽  
Related Complication ◽  
Initial Intervention ◽  
Work Up

With the advancement and industrialization of our society, the prevalence of metabolic disease is also increasing. Among the risk factors for metabolic syndrome and many other non-communicable diseases, obesity is the single most important one. Although life style and pharmacological therapies are the part of initial intervention, however once the overt obesity related complication appears, bariatric surgery becomes the only curative intervention. Various modalities surgeries have come into place in recent times. However preparing a patient physically and mentally needs a thorough pre- operative preparation. Here in this review, we are exploring the approach to patient with morbid obesity and work up for bariatric surgery from a physician’s point of view.

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