Low plasma C-reactive protein level as an early diagnostic tool for heatstroke vs central nervous system–associated infection in the ED

Aged and young unanesthetized rabbits with intracerebroventricular cannulas were tested in experiments designed to determine whether increases in plasma C-reactive protein (CRP) level and leukocytosis can be rapidly induced by central administration of crude buffy-coat supernatant commonly called endogenous pyrogen or interleukin 1 (IL 1). The results indicate that both acute-phase responses occur during fever caused by central administration of this supernatant and that they are generally detectable within 2 h. Although the febrile response was smaller in aged female rabbits, there was no decline in CRP or leukocyte responses, an observation that was not predicted. The antipyretic neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) reduced fever caused by central IL 1 more effectively in the aged rabbits. alpha-MSH likewise inhibited the CRP and leukocyte responses to central IL 1. The results confirm that CRP and leukocyte responses can be driven by a central IL 1 signal and further indicate that the response can occur rapidly, consistent with direct central nervous system control of the acute-phase responses. The findings indicate that the acute-phase responses depend in part on the age of the host and that the responses can be modulated by an endogenous central nervous system peptide with known antipyretic and immune modulatory properties.

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Early Ditection of Central Nervous System Infection by C-reactive Protein Examination of Cerebrospinal Fluid

Paediatrica Indonesiana ◽

10.14238/pi32.5-6.1992.144-52 ◽

2019 ◽

Vol 32 (5-6) ◽

pp. 144-52

Author(s):

Tjipta Bahtera ◽

Bagus Putu Ngurah Arsana ◽

Maria Lidwina

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Bacterial Meningitis ◽

Clinical Symptoms ◽

Central Nervous System Infection ◽

Spinal Fluid ◽

Morbidity Rate ◽

C Reactive Protein ◽

Routine Examination ◽

Reactive Protein

There are still many cases of bacterial meningitis in Indonesia. The highest morbidity rate are between 2 months until 2 years of age. The important factors that influence the success of treatment are early diagnosis and detection of the cause. C-reactive protein (=CRP) could be found in the spinal fluid of meningitis patients. The aim of this study is to judge the ability of CRP as a tool in making diagnosis as soon as possible whether there is a bacterial infection of the central nervous system and to compare it with the result of the spinal fluid culture. Also to compare the ability of it a conventional or routine examination of the spinal fluid was done. This was a prospective study on 30 children that were admitted in the child ward of Kariadi Hospital, Semarang during the first of April until the and of july 1990. The ages of the children were between one month until 14 years, with clinical symptoms such as fever, seizure and neurological disorders. CRP examination was done with Latex Agglutination method. The result of CRP examination on spinal fluid showed that the sensitivity was 91.6% , the specificity 94.4% , the positive prediction value 91.6% and the negative prediction value 94.4%. As a conclusion, CRP examination of spinal fluid gives better results than the conventional or routine examination in distinguishing bacterial meningitis from non bacterial meningitis.

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Influence of 2-ethyl- 6-methyl-3-hydroxypyridine succinate on blood c-reactive protein level in patients with acute myocardial infarction and cognitive disorders

Problems of Uninterrupted Medical Training and Science ◽

10.31071/promedosvity2018.01.077 ◽

2018 ◽

Vol 2018 (1) ◽

pp. 77-80

Author(s):

K. S. Stroienko ◽

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Protein Level ◽

Cognitive Disorders ◽

C Reactive Protein ◽

Reactive Protein

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Predictive factors of perforated appendicitis: Impact of the C-reactive protein level

Surgery Open Science ◽

10.1016/j.sopen.2021.06.003 ◽

2021 ◽

Author(s):

Shiori Yamazaki ◽

Yusuke Shimodaira ◽

Akira Kobayashi ◽

Manabu Takata ◽

Kaori Hayashibara ◽

...

Keyword(s):

Predictive Factors ◽

Protein Level ◽

Perforated Appendicitis ◽

C Reactive Protein ◽

Reactive Protein

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Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study

European Journal of Medical Research ◽

10.1186/s40001-021-00553-3 ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Ghodsiyeh Azarkar ◽

Freshteh Osmani

Keyword(s):

Risk Factors ◽

Platelet Count ◽

Protein Level ◽

Clinical Characteristics ◽

Single Center ◽

C Reactive Protein ◽

Reactive Protein ◽

Risk Of Death ◽

Survivor Group ◽

Epidemiological Characteristics

Abstract Background The coronavirus disease 2019(COVID-19) has affected mortality worldwide. The Cox proportional hazard (CPH) model is becoming more popular in time-to-event data analysis. This study aimed to evaluate the clinical characteristics in COVID-19 inpatients including (survivor and non-survivor); thus helping clinicians give the right treatment and assess prognosis and guide the treatment. Methods This single-center study was conducted at Hospital for COVID-19 patients in Birjand. Inpatients with confirmed COVID-19 were included. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Independent sample T test and the Chi-square test or Fisher’s exact test were used to evaluate the association of interested variables. The CPH model was used for survival analysis in the COVID-19 death patients. Significant level was set as 0.05 in all analyses. Results The results showed that the mortality rate was about (17.4%). So that, 62(17%) patients had died due to COVID-19, and 298 (83.6%) patients had recovered and discharged. Clinical parameters and comorbidities such as oxygen saturation, lymphocyte and platelet counts, hemoglobin levels, C-reactive protein, and liver and kidney function, were statistically significant between both studied groups. The results of the CPH model showed that comorbidities, hypertension, lymphocyte counts, platelet count, and C-reactive protein level, may increase the risk of death due to the COVID-19 as risk factors in inpatients cases. Conclusions Patients with, lower lymphocyte counts in hemogram, platelet count and serum albumin, and high C-reactive protein level, and also patients with comorbidities may have more risk for death. So, it should be given more attention to risk management in the progression of COVID-19 disease.

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