Consequences of a low protein diet on the liver and longissimus dorsi transcriptome of Duroc × Iberian crossbred pigs

Banana stem is a common feed component for raising pigs in mountainous Southeast Asia. However, its nutritive value and digestibility are low. This study was carried out to investigate the effects of unfermented and fermented banana stems on crossbred pigs concerning nutrient digestibility, productive performance, and intestinal morphology. Initially, an in vitro ileal digestibility test was performed for the following feedstuffs: fresh banana stem (BS), fermented banana stem (FBS), concentrate (C), fresh banana stem + concentrate (BSC), and fermented banana stem + concentrate (FBSC). For the 120-day experiment, 16 crossbred pigs were divided into two groups and fed with BSC and FBSC. They were placed in individual cages and subsequently moved to metabolic cages for seven days to determine apparent total tract digestibility (ATTD). Finally, all pigs were slaughtered and their small intestines were analyzed for intestinal morphology. The results show that pure fresh and fermented banana stems had low digestibility. However, their digestibility increased by 50% when mixed with concentrate. Crossbred pigs fed BSC and FBSC did not exhibit significant differences in their performance, but the intestinal morphology of the FBSC group had improved intestinal morphology, especially the villi height. In conclusion, both fresh and fermented banana stems can be recommended in a low protein diet as feed for crossbred pigs in an improved production system. This is relevant for raising pigs in mountainous areas, as it has the potential to reduce feed cost and maintain production performance.

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Hepatic Ultrastructure Changes Induced by Lithocholic Acid

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100060829 ◽

1967 ◽

Vol 25 ◽

pp. 162-163 ◽

Cited By ~ 1

Author(s):

F. G. Zaki

Keyword(s):

Endoplasmic Reticulum ◽

Lithocholic Acid ◽

Smooth Endoplasmic Reticulum ◽

Protein Diet ◽

Low Protein Diet ◽

Electron Microscopic ◽

Hydropic Degeneration ◽

Hepatic Cells ◽

Low Protein ◽

Microscopic Studies

Addition of lithocholic acid (LCA), a naturally occurring bile acid in mammals, to a low protein diet fed to rats induced marked inflammatory reaction in the hepatic cells followed by hydropic degeneration and ductular cell proliferation. These changes were accompanied by dilatation and hyperplasia of the common bile duct and formation of “gallstones”. All these changes were reversible when LCA was withdrawn from the low protein diet except for the hardened gallstones which persisted.Electron microscopic studies revealed marked alterations in the hepatic cells. Early changes included disorganization, fragmentation of the rough endoplasmic reticulum and detachment of its ribosomes. Free ribosomes, either singly or arranged in small clusters were frequently seen in most of the hepatic cells. Vesiculation of the smooth endoplasmic reticulum was often encountered as early as one week after the administration of LCA (Fig. 1).

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Ernährung bei chronisch Nierenkranken – Wie kann man eine Low-Protein-Diet erreichen?

Dialyse aktuell ◽

10.1055/s-0035-1555716 ◽

2015 ◽

Vol 19 (05) ◽

pp. 256-256

Keyword(s):

Protein Diet ◽

Low Protein Diet ◽

Low Protein

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Project report: the effect of maternal low protein diet on the neuromuscular system of the offspring in mice

10.36866/pn.101.11 ◽

2016 ◽

pp. 11-11

Author(s):

Ifigeneia Giakoumaki

Keyword(s):

Protein Diet ◽

Low Protein Diet ◽

Neuromuscular System ◽

Project Report ◽

Low Protein

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Economic Effects of Treatment of Chronic Kidney Disease with Low-Protein Diet

SSRN Electronic Journal ◽

10.2139/ssrn.2338432 ◽

2013 ◽

Author(s):

Francesco Saverio Mennini ◽

Simone Russo ◽

Andrea Marcellusi ◽

Giuseppe Quintaliani ◽

Denis Fouque

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Economic Effects ◽

Protein Diet ◽

Low Protein Diet ◽

Low Protein

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PSIV-6 Effect of a Phytogenic Water Additive on Growth Performance, Blood Metabolites and Gene Expression of Amino Acids Transporters in Nursery Pigs Fed with Low Protein Diets

Journal of Animal Science ◽

10.1093/jas/skaa278.507 ◽

2020 ◽

Vol 98 (Supplement_4) ◽

pp. 281-282

Author(s):

Cedrick N Shili ◽

Mohammad Habibi ◽

Julia Sutton ◽

Jessie Barnes ◽

Jacob Burchkonda ◽

...

Keyword(s):

Gene Expression ◽

Amino Acids ◽

Growth Performance ◽

Mrna Abundance ◽

Protein Diet ◽

Low Protein Diet ◽

Blood Calcium ◽

Low Protein ◽

Protein Diets ◽

Standard Protein

Abstract Moderately low protein (MLP) diets can help decrease nutrient excretion from the swine production. However, MLP diets negatively impact growth performance. We hypothesized that supplementing MLP diets with phytogenics may reduce the negative effects of these diets on growth. The objective of this study was to investigate the effect of a phytogenic water additive (PWA; Herbanimal®) on growth performance, blood metabolite and gene expression of amino acids transporters in pigs fed with MLP diets. Forty-eight weaned barrows were allotted to six dietary treatments (n = 8) for 4 weeks: >CON-NS: standard protein diet-no PWA; CON-LS: standard protein diet-low PWA dose (4 ml/L); CON-HS: standard protein diet-high PWA dose (8 ml/L); LP-NS: low protein diet-no PWA; LP-LS: low protein diet-low PWA dose (4 ml/L); LP-HS: low protein diet- high PWA dose (8 ml/L). Feed intake and body weight were recorded daily and weekly, respectively. At week 4, blood and tissue samples were collected and analyzed for metabolites using a chemistry analyzer and amino acid transporters using qPCR, respectively. The data were analyzed by univariate GLM (SPSS®) and the means were separated using paired Student’s t-test corrected by Benjamini-Hochberg. Pigs fed CON-HS improved the average daily gain and serum calcium and phosphorus concentrations compared to CON-NS. Pigs fed LP-LS had higher serum phosphorus and blood urea nitrogen compared to the pigs fed with LP-NS. The mRNA abundance of SLC7A11 in the jejunum was lower in CON-LS and CON-HS compared to CON-NS. Additionally, mRNA abundance of SLC6A19 in the jejunum of pigs fed with LP-LS was higher compared to LP-NS and lower in CON-HS relative to pigs fed with CON-LS. In conclusion, PWA improved the growth performance of pigs fed standard protein diets but not low protein diets. Further, the PWA improved the concentrations of blood calcium and phosphorous in pigs fed MLP diets. Funding: Agrivida and Animal Health and Production and Animal Products: Improved Nutritional Performance, Growth, and Lactation of Animals from the USDA-NIFA.

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