scholarly journals Vanadium in high-fat diets sourced from egg yolk decreases growth and antioxidative status of Wistar rats

2019 ◽  
Vol 5 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Jian-Ping Wang ◽  
Ren-Yong Cui ◽  
Xue-Mei Ding ◽  
Shi-Ping Bai ◽  
Qiu-Feng Zeng ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Egg Yolk ◽  
High Fat ◽  
Antioxidative Status ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals The Role of High Fat Diets and Liver Peptidase Activity in the Development of Obesity and Insulin Resistance in Wistar Rats

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 636
Author(s):  
Germán Domínguez-Vías ◽  
Ana Belén Segarra ◽  
Manuel Ramírez-Sánchez ◽  
Isabel Prieto
Keyword(s):  
Glucose Metabolism ◽  
Wistar Rats ◽  
Metabolic Disorders ◽  
Peptidase Activity ◽  
High Fat ◽  
Β Cell ◽  
High Fat Diets ◽  
Glutamyl Transferase ◽  
Fat Diets

High-fat diets (HFD) have been widely associated with an increased risk of metabolic disorders and overweight. However, a high intake of sources that are rich in monounsaturated fatty acids has been suggested as a dietary agent that is able to positively influence energy metabolism and vascular function. The main objective of this study was to analyze the role of dietary fats on hepatic peptidases activities and metabolic disorders. Three diets: standard (S), HFD supplemented with virgin olive oil (VOO), and HFD supplemented with butter plus cholesterol (Bch), were administered over six months to male Wistar rats. Plasma and liver samples were collected for clinical biochemistry and aminopeptidase activities (AP) analysis. The expression of inducible nitric oxide synthase (iNOS) was also determined by Western blot in liver samples. The diet supplement with VOO did not induce obesity, in contrast to the Bch group. Though the VOO diet increased the time that was needed to return to the basal levels of plasma glucose, the fasting insulin/glucose ratio and HOMA2-%B index (a homeostasis model index of insulin secretion and valuation of β-cell usefulness (% β-cell secretion)) were improved. An increase of hepatic membrane-bound dipeptidyl-peptidase 4 (DPP4) activity was found only in VOO rats, even if no differences in fasting plasma glucagon-like peptide 1 (GLP-1) were obtained. Both HFDs induced changes in hepatic pyroglutamyl-AP in the soluble fraction, but only the Bch diet increased the soluble tyrosyl-AP. Angiotensinase activities that are implicated in the metabolism of angiotensin II (AngII) to AngIV increased in the VOO diet, which was in agreement with the higher activity of insulin-regulated-AP (IRAP) in this group. Otherwise, the diet that was enriched with butter increased soluble gamma-glutamyl transferase (GGT) and Leucyl-AP, iNOS expression in the liver, and plasma NO. In summary, VOO increased the hepatic activity of AP that were related to glucose metabolism (DPP4, angiotensinases, and IRAP). However, the Bch diet increased activities that are implicated in the control of food intake (Tyrosine-AP), the index of hepatic damage (Leucine-AP and GGT), and the expression of hepatic iNOS and plasma NO. Taken together, these results support that the source of fat in the diet affects several peptidases activities in the liver, which could be related to alterations in feeding behavior and glucose metabolism.

Hepatoprotective effect of chewable tablet of Centella asiatica (L.) Urb extractin Wistar rats induced by high fat diets

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Akrom ◽  
Feri Anggita Hastanto ◽  
Laela hayu Nurani
Keyword(s):  
Wistar Rats ◽  
Serum Triglyceride ◽  
Centella Asiatica ◽  
High Fat ◽  
Chewable Tablet ◽  
High Fat Diets ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Fat Diets

Gotukola or Centella asiatica (L.) Urban contains high flavonoids which well known as fatty liver protector. This study aimed to evaluate the hepatoprotective effect of chewable tablet of C. asiatica (L.) Urb extract (CTCE) in Wistar rats induced by high fat diets. Twenty-one Wistar male rats aged 8-12 weeks with body weight ranging from 100-150 g were used in this study. Rats were randomly divided into seven groups i.e. Group 1 as normal control, rats were given standard food, Group 2 as high fat diets control, rats were induced high fat diets (HFD),Group 3 as positive control, rats were induced HFD and given simvastatin, Group 4 as placebo control, rats were induced HFD and given placebo, Group 5-7 as treatment group, rats were induced HFD and given CTCE at doses of 100, 200 and 300 mg/kg BW, respectively. The HFD induction was conducted for five weeks andthe CTCE was given for one week in the last week of the induction. At the end of the intervention, blood triglyceride levels and SGPT as well SGOT activities were examined. Analysis of variance (ANOVA) with confidence interval of 95% (p<0.05) was applied. The results showed that the HFD induction increased the serum triglyceride levels and SGPT activity. The serum triglyceride levels and SGPT activity of Group 2 were significantly higher than Group 1 (p<0.05). Furthermore, the simvastatin and CTCE administration reduced the serum triglyceride levels and SGPT activity. The serum triglyceride levels and SGPT activity of Group 3, 5, 6and 7 were significantly lower than Group 2 and 4 (p<0.05). In addition, the serum triglyceride levels and SGPT activity of Group 5, 6 and 7 were significantly lower than Group 3 (p<0.05). In conclusion, CTCE can reduce the serum triglyceride levels and SGPT activity in Wistar rats induced by HFD.

scholarly journals Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

2014 ◽  
Vol 29 (3) ◽  
pp. 178-185 ◽  
Author(s):  
Ana Lígia da Silva Nassar ◽  
Luisa Pereira Marot ◽  
Paula Payão Ovidio ◽  
Gabriela Salim Ferreira de Castro ◽  
Alceu Afonso Jordão Júnior
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Food Restriction ◽  
Wistar Rats ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Myocardial Stereological Adaptations in Wistar Rats Fed with Different High-Fat Diets during 18 Months.

2001 ◽  
Vol 47 (6) ◽  
pp. 387-393 ◽  
Author(s):  
Marcia Barbosa AGUILA ◽  
Carlos Alberto MANDARIM-DE-LACERDA
Keyword(s):  
Wistar Rats ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Effects of high fat diets on worm recovery, growth and distribution of Echinostoma caproni in ICR mice

1996 ◽  
Vol 70 (4) ◽  
pp. 351-354 ◽  
Author(s):  
J.E. Sudati ◽  
A. Reddy ◽  
B. Fried
Keyword(s):  
Control Diet ◽  
Dry Weight ◽  
Egg Yolk ◽  
Significant Decline ◽  
High Fat ◽  
Echinostoma Caproni ◽  
Icr Mice ◽  
High Fat Diets ◽  
Standard Laboratory Diet ◽  
Fat Diets

AbstractThe effects of high fat diets (HFDs) on the host–parasite relationship of Echinostoma caproni in ICR mice were studied. Two HFDs were used, one consisting of a customized high fat diet (CHFD) with 45% lipid in the form of cottonseed oil, and the second consisting of an egg yolk diet (EYD) from domestic hens' eggs, with 31% lipid. Controls for both diets consisted of mice fed a standard laboratory diet with 5% lipid. Mice were each fed 25 cysts of E. caproni by stomach tube and necropsied 2, 3 and 4 weeks postinfection (PI). The weight of mice on the CHFD declined significantly compared to mice on the control diet, but there was no significant decline in weight of mice fed EYD compared to the controls. Worm recoveries from mice on both HFDs were significantly less than those from control hosts. There was a significant decline in worm dry weight, body area and uterine egg counts in worms on HFD compared to those on the control diet. Worms from hosts on HFD were located more anteriad in the gut than those recovered from mice on the control diet.

Heart and blood pressure adaptations in Wistar rats fed with different high-fat diets for 18 months

Nutrition ◽  
2003 ◽  
Vol 19 (4) ◽  
pp. 347-352 ◽  
Author(s):  
Marcia B Aguila ◽  
Carlos Alberto Mandarim-de-Lacerda
Keyword(s):  
Blood Pressure ◽  
Wistar Rats ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Long-Term Exposure to [Cr3O(O2CCH2CH3)6(H2O)3]+ in Wistar Rats Fed Normal or High-Fat Diets Does Not Alter Glucose Metabolism

2012 ◽  
Vol 151 (3) ◽  
pp. 406-414 ◽  
Author(s):  
Betty J. Herring ◽  
Amanda L. Logsdon ◽  
Jarrett E. Lockard ◽  
Brittany M. Miller ◽  
Hanna Kim ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Wistar Rats ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

1994 ◽  
Vol 71 (06) ◽  
pp. 755-758 ◽  
Author(s):  
E M Bladbjerg ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
High Fat Diet ◽  
Fat Content ◽  
Factor Vii ◽  
Amidolytic Activity ◽  
High Fat ◽  
Low Fat Diet ◽  
Increased Risk ◽  
Coagulant Activity ◽  
High Fat Diets ◽  
Fat Diets

SummaryPreliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVIPAm). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII: Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.

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