Melatonin inhibits reproductive activity through changes of serotonergic activity in the brain of freshwater catfish (Mystus cavasius)

Serotonin plays a role at the pathophysiology of depression in humans and in experimental models. The present study investigated the depressive behavior and the weigh evolution in adult rats (60 days) treated from the 1st to the 21st postnatal day with fluoxetine, a selective serotonin reuptake inhibitor (10 mg/kg, sc, daily). The depressive behavior was induced by the forced swim test (FST). The animals were submitted to two sessions of FST: 1st session for 15 min and the 2nd session 24h later, for 5 min. During the 2nd session the Latency of the Attempt of Escape (LAE) and Behavioral Immobility (BI) were appraised. The Fluoxetine group when compared to the Control group, showed an increase in LAE and a decrease in BI. The neonatal administration of fluoxetine reduced the depressive behavior in adult rats, possibly by increase in the brain serotonergic activity. This alteration can be associated to process of neuroadaptation.

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P300 event-related potential and serotonin-1A activity in depression

European Psychiatry ◽

10.1016/s0924-9338(99)80732-9 ◽

1999 ◽

Vol 14 (3) ◽

pp. 143-147 ◽

Cited By ~ 18

Author(s):

M Hansenne ◽

M Ansseau

Keyword(s):

Critical Role ◽

Brain Structures ◽

Significant Negative Correlation ◽

Event Related Potential ◽

P300 Amplitude ◽

P300 Latency ◽

Endocrine Response ◽

Major Depressive ◽

Serotonergic Activity ◽

The Brain

SummaryThe identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

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Bulbospinal serotonergic activity during changes in thyroid status

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y98-131 ◽

1998 ◽

Vol 76 (12) ◽

pp. 1120-1131 ◽

Cited By ~ 8

Author(s):

William N Henley ◽

Linda L Bellush ◽

Marc Tressler

Keyword(s):

Thyroid Hormone ◽

Primary Hypothyroidism ◽

Glycemic Status ◽

Thyroid Status ◽

Hormone Levels ◽

Serotonergic Activity ◽

Thyroid Hormone Levels ◽

The Brain ◽

Circulating Levels ◽

Very High

A three-part study explored the basis for an interaction between changes in thyroid status and bulbospinal serotonin (5HT) metabolism. In experiment 1, three well-characterized models of primary hypothyroidism were all accompanied by significant increases in 5HT metabolism. In experiment 2, circulating thyroid hormone levels were experimentally varied from very low methimazole (Meth) treatment to very high (T3 implants: 2.5, 5.0, or 7.5 mg triiodothyronine). As in experiment 1, Meth led to elevated 5HT. Hyperthyroidism was accompanied by significant reductions in 5HT, while urinary norepinephrine excretion paralleled 5HT. In experiment 3, rats were subjected to Meth either 2 weeks before or after induction of diabetes with streptozotocin (Stz). Meth prevented Stz-associated reductions in 5HT and attenuated development of hyperphagia. Meth could not reverse established Stz-associated reduction in 5HT or hyperphagia, although both were slightly attenuated. Thus, although the first two experiments argue for a simple inverse relationship between circulating thyroid hormone levels and 5HT in the brain, experiment 3 demonstrated that Stz-associated decrements in 5HT could not be reversed by subsequent lowering of circulating thyroid hormone. Nor did accompanying measurements indicate that glycemic status or circulating levels of leptin were important predictors of 5HT. Thus the interaction between thyroid hormones and 5HT is both more subtle and more complex than previously thought.Key words: hypothyroidism, hyperthyroidism, serotonin, diabetes mellitus.

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Rotenone alters behavior and reproductive functions of freshwater catfish, Mystus cavasius, through deficits of dopaminergic neurons in the brain

Chemosphere ◽

10.1016/j.chemosphere.2020.128355 ◽

2021 ◽

Vol 263 ◽

pp. 128355

Author(s):

Muhammad Badruzzaman ◽

Md Shahjahan ◽

Prodip Kumar Roy ◽

Md Taimur Islam

Keyword(s):

Dopaminergic Neurons ◽

Freshwater Catfish ◽

The Brain

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Possible roles of photoperiod and melatonin in reproductive activity via changes in dopaminergic activity in the brain of a tropical damselfish, Chrysiptera cyanea

General and Comparative Endocrinology ◽

10.1016/j.ygcen.2013.09.012 ◽

2013 ◽

Vol 194 ◽

pp. 240-247 ◽

Cited By ~ 19

Author(s):

Muhammad Badruzzaman ◽

Mohammad Abu Jafor Bapary ◽

Akihiro Takemura

Keyword(s):

Reproductive Activity ◽

Dopaminergic Activity ◽

The Brain

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A Case of MDMA-Associated Cerebral and Pulmonary Edema Requiring ECMO

Case Reports in Critical Care ◽

10.1155/2017/6417012 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

A. Thakkar ◽

K. Parekh ◽

K. El Hachem ◽

E. M. Mohanraj

Keyword(s):

Pulmonary Edema ◽

Cerebral Edema ◽

Distress Syndrome ◽

Neurogenic Pulmonary Edema ◽

Severe Hyponatremia ◽

Brain Computed Tomography ◽

Serotonergic Activity ◽

Life Saving ◽

Clonic Seizures ◽

The Brain

A 20-year-old female presented with confusion, generalized tonic-clonic seizures, and severe hyponatremia after ingesting 3,4-methylenedioxymethamphetamine (MDMA). Brain computed tomography (CT) demonstrated cerebral edema. Her hospital course was rapidly complicated by respiratory failure and shock requiring intubation and vasopressors. Refractory acute respiratory distress syndrome (ARDS) was diagnosed which was unresponsive to conventional and salvage therapies, requiring initiation of extracorporeal membrane oxygenation (ECMO), leading to normalization of oxygenation parameters. Hyponatremia was corrected and the encephalopathy resolved. The patient was decannulated and extubated after three days. MDMA-induced hyponatremia is hypothesized to result from enhanced serotonergic activity and arginine vasopressin (AVP) release in the brain leading to hyperthermia-induced polydipsia and syndrome of inappropriate antidiuretic hormone (SIADH) secretion. A common but often unrecognized complication of severe hyponatremia is the Ayus-Arieff syndrome where cerebral edema causes neurogenic pulmonary edema via centrally mediated increases in catecholamine release and capillary injury. For our patient, ECMO was required for three days while the hyponatremia was corrected which led to rapid clearing of the cerebral edema and neurogenic pulmonary edema. This case illustrates that, in selecting patients with refractory ARDS from MDMA-associated cerebral and pulmonary edema, ECMO may be a temporizing and life-saving modality of treatment.

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The Effect of Stress and Starvation on Bratn Serotonin Utilization in Arctic Charr (Salvelinus Alpinus)

Journal of Experimental Biology ◽

10.1242/jeb.165.1.229 ◽

1992 ◽

Vol 165 (1) ◽

pp. 229-239 ◽

Cited By ~ 2

Author(s):

SVANTE WINBERG ◽

GÖRAN E. NILSSON ◽

K. HÅKAN OLSÉN

Keyword(s):

Brain Stem ◽

Salvelinus Alpinus ◽

Arctic Charr ◽

Serotonergic Activity ◽

Brain Levels ◽

Hydroxyindoleacetic Acid ◽

Experimental Protocols ◽

Effects Of Stress ◽

The Brain ◽

Starvation Experiment

The effects of stress and starvation on brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were studied in Arctic charr (Salvelinus alpinus). Three experimental protocols were used to elucidate (1) the effect of stress in fish given food, (2) the effect of starvation, and (3) the effect of stress in fish deprived of food. In the stress experiments, fish were stressed three times a day over a four-week period, and in the starvation experiment the fish were starved for a four-week period. Stressed fish, whether given food or not, showed significantly higher concentrations of 5-HIAA, the main 5-HT metabolite, in both the telencephalon and the brain stem. The 5-HIAA/5-HT ratio (an index of serotonergic activity) was also significantly increased in the brain of stressed fish. In the telencephalon of starved fish, the 5-HT concentration was significantly decreased. However, starvation had no effect on 5-HIAA concentrations or 5-HIAA/5-HT ratios in either the telencephalon or the brain stem. These results suggest that stress increases brain serotonergic activity in Arctic charr, while starvation has no effect on the utilization of this transmitter system. It is suggested that stress could be a mediator of the increased 5-HTAA levels and 5-HIAA/5-HT ratios recently observed in low-ranking Arctic charr in a dominance hierarch.

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S42.03 Test of Serotonergic Activity in the Brain Predicts Therapeutic Response of Patients with Schizophrenia

European Psychiatry ◽

10.1016/s0924-9338(00)94316-5 ◽

2000 ◽

Vol 15 (S2) ◽

pp. 301s-301s ◽

Cited By ~ 1

Author(s):

J. Libiger ◽

P. Mohr ◽

J. Horáček ◽

P. Czobor ◽

R. Bahbouch

Keyword(s):

Therapeutic Response ◽

Serotonergic Activity ◽

The Brain

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Nutritional status affects the microRNA profile of the hypothalamus of female sheep

Reproduction Fertility and Development ◽

10.1071/rd17179 ◽

2018 ◽

Vol 30 (7) ◽

pp. 946 ◽

Cited By ~ 1

Author(s):

Heng Yang ◽

Shan Lin ◽

Xiaoping Lei ◽

Cong Yuan ◽

Yaosheng Yu ◽

...

Keyword(s):

Nutritional Status ◽

Molecular Mechanisms ◽

Reproductive Activity ◽

Illumina Hiseq ◽

Illumina Hiseq Sequencing ◽

Photoperiodic Regulation ◽

Micro Rnas ◽

Microrna Profile ◽

Polymerase Chain ◽

The Brain

Recent studies on the seasonal regulation of the oestrous cycle in sheep have focussed mainly on the responses to photoperiod. However, the brain systems that control reproductive activity also respond to nutritional inputs, although the molecular mechanisms involved are not completely understood. One possibility is that small, non-coding RNAs, such as micro-RNAs (miRNAs), have significant influence. In the present study, the amounts and characteristics of miRNAs in hypothalamus from oestrous and anestrous ewes, fed low- or high-nutrient diets, were compared using Illumina HiSeq sequencing technology. In total, 398 miRNAs, including 261 novel miRNAs, were identified in ewes with an enhanced nutritional status (HEN), whereas 384 miRNAs, including 247 novel miRNAs, were identified in the ewes with a lesser nutritional status (HAN). There were eight conserved and 140 novel miRNAs expressed differentially between the two libraries. Based on quantitative real-time polymerase chain reaction, six miRNAs were assessed to verify the accuracy of the library database. Moreover, the correlation between the miRNA target and several upstream and downstream genes in the oestrus-related pathways were also verified in hypothalamus nerve cells. According to the results, nutritional status plays an important role in oestrous regulation in sheep, and the hypothalamic processes and pathways induced by nutritional signals (folic acid and tyrosine) are different from those induced by photoperiodic regulation of oestrus. We have expanded the repertoire of sheep miRNAs that could contribute to the molecular mechanisms that regulate the initiation of oestrous cycles in anestrous ewes in response to the influence of nutritional status.

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