P300 event-related potential and serotonin-1A activity in depression

1999 ◽  
Vol 14 (3) ◽  
pp. 143-147 ◽  
Author(s):  
M Hansenne ◽  
M Ansseau
Keyword(s):  
Critical Role ◽  
Brain Structures ◽  
Significant Negative Correlation ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Endocrine Response ◽  
Major Depressive ◽  
Serotonergic Activity ◽  
The Brain

SummaryThe identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

scholarly journals Neuro-Cognitive Profile of Morning and Evening Chronotypes at Different Times of Day

2021 ◽  
pp. 097275312199028
Author(s):  
Nanditha Venkat ◽  
Meenakshi Sinha ◽  
Ramanjan Sinha ◽  
Jayshri Ghate ◽  
Babita Pande
Keyword(s):  
Statistical Tests ◽  
Power Spectral Analysis ◽  
Significant Negative Correlation ◽  
Cognitive Status ◽  
Event Related Potential ◽  
Fast Fourier Transformation ◽  
P300 Latency ◽  
Cognitive Measures ◽  
Circadian Time ◽  
Beta Power

Background: Chronotype is the circadian time preference for sleep–wake timings. However, its impact on cognitive performance is least explored. Objective: The present study investigated the effect of chronotype (morning “M” vs. evening “E”) on cognitive measures as a function of time of the day. In addition, the correlation between electroencephalogram (EEG) waves and subjective/objective cognitive measures were investigated. Method: Cognitive status of 28 adult male subjects (15 “M” and 13 “E”) was assessed objectively through event-related potential (ERP) by administering visual odd ball paradigm test and subjectively through Montreal Cognitive Assessment questionnaire. In addition, 20 to 30 min of resting EEG was recorded. Recordings were done from 8 to 10 am and from 4 to 6 pm on a single day. Power spectral analysis of EEG for alpha and beta waves at PZ and FZ cortical sites was done after subjecting selected epochs to fast Fourier transformation. Also, latency and amplitude of P300 potential from event-related potential record were measured. Appropriate statistical tests were applied for analysis. Results: Higher alpha and beta power was observed in “E” at PZ in the evening. “M” showed increased P300 latency and amplitude during evening session for frequent and rare stimuli and vice versa in “E.”’ Significant negative correlation was seen between latency of rare stimuli and alpha and beta power at FZ site during evening in “E” chronotype only. Conclusion: Result indicates better attention and alertness during evening hours in evening chronotypes and vice versa in morning chronotypes. The findings could be implemented to schedule the mental performance/cognitive load according to individual chronotype.

scholarly journals Emotional Substrates in Neuroticism: The Reactions to Arousal-evoking Stimuli of Various Strengths

2020 ◽  
Vol 19 (2) ◽  
pp. 262-267
Author(s):  
Nasir Yusoff ◽  
Faruque Reza ◽  
Nik NurAzhani Anuar ◽  
Roslee Ahmad
Keyword(s):  
Significant Interaction ◽  
Medical Condition ◽  
Medical Science ◽  
Visual Stimuli ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Significant Interaction Effect ◽  
Mean Values ◽  
Emotional Pictures

Objective: Neuroticism is a medical condition associated with negative affect and is considered to predispose one to mental disorders. This study examined the effectsof arousal-evoking stimuli of various strengths on the severity of neuroticism. Materials and Methods: In the Event Related Potential (ERP)/electroencephalograph (EEG) recording session that was held at the Clinical Neuroscience Laboratory at a local hospital, Electroencephalogram was recorded in 58 participants (N=29 for moderate neuroticism and 29 for mild neuroticism) after they were screened for the severity of the neurotic trait. Universal emotional pictures were chosen randomly from the International Affective Picture System (IAPS) and were used as visual stimuli in the experiment. Visual stimuli weredivided into three categories (high, moderate, low) based on the IAPS normative mean values of arousal. Results: The significant interaction effect of P300 latency between neuroticism and arousal strength was found in the mid-frontal region. Meanwhile, independent of neuroticism, the main effects of arousal strength of the P300 (amplitude and latency) and N200 (latency) were observed in the mid-central region. Conclusion: There is a significant interaction between the severity of neuroticism and the emotional arousal strength, thus, points to the implication of the emotion process in the brain rewards system especially among individuals with neuroticism. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.262-267

scholarly journals P300 and decision-making in neuromarketing

2021 ◽  
Vol 4 (3) ◽  
pp. 21-26
Author(s):  
Aida Azlina Mansor ◽  
Salmi Mohd Isa ◽  
Syaharudin Shah Mohd Noor
Keyword(s):  
Decision Making ◽  
Test Methods ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Decision Making Process ◽  
Related Research ◽  
P300 Wave ◽  
Human Event ◽  
Marketing Methods

Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of decision-making is P300. Thus, the P300 wave is a potential Event-Related Component (ERP) used to measure consumers' decision-making process. The P300 wave represents a positive transition in human event-related potential. Therefore, the P300 is determined by measuring the amplitude and latency of the consumers. A higher P300 amplitude indicates greater confidence in the decision-making process, while a longer P300 latency indicates lower attentiveness. Thus, P300 in neuroscience, which investigates customers' responses in-depth, cannot be accomplished by typical marketing methods. For many years, P300 components such as attitudes, preferences, and information-based decision-making have been examined extensively in marketing-related research. However, a review of an ERP in neuromarketing method is fewer reported. This mini review describes some analysis on P300 and decision-making by several researchers.

scholarly journals Relationship between enlarged perivascular space in hippocampus and P300 event-related potential in patients with acute lacunar stroke

2021 ◽  
Author(s):  
Shan Huang ◽  
Zhixiang Zhang ◽  
Yuqing Mei ◽  
Kuankuan Huang ◽  
Yiping Feng ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Roc Curve ◽  
Verbal Fluency ◽  
Perivascular Space ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Lacunar Stroke ◽  
The Relationship ◽  
P300 Event Related Potential

Abstract Background This study aimed to investigate the relationship between enlarged perivascular space in hippocampus (H-EPVS) and P300 event-related potential (ERP) in patients with acute lacunar stroke. Methods Patients with acute lacunar stroke hospitalized in Changzhou No.2 people's Hospital from February 2019 to July 2020 were collected. All the patients performed the P300 auditory oddball task and a full set of cognitive function tests. We recorded P300 latency and amplitude by EMG evoked potential instrument. H-EPVS showed round, oval and linear structures on MRI T2-weighted images of hippocampus, with clear boundaries and consistency in the direction of the perforating arterioles. Dividing the total number of H-EPVS ≥ 7 into extensive H-EPVS group (n = 61) and non-extensive H-EPVS group (n = 53). ROC curve was used to analyze the relationship between P300 ERP and cognitive function of extensive H-EPVS in patients with acute lacunar stroke. Results A total of 114 patients with acute lacunar stroke were included, and 61 (53.5%) patients were found to have extensive H-EPVS. The P300 latency in patients with extensive H-EPVS( mean and SD, 393.61 ± 30.36) was significantly higher than in non-extensive H-EPVS (mean and SD, 356.4 ± 19.59 ms, t = -7.870, P < 0.01). There was no significant difference in P300 amplitude between the two groups (P > 0.05). In addition, The cognitive function (the field of verbal fluency) in patients with extensive H-EPVS (mean and SD, -0.41 ± 0.50) was significantly lower than in non-extensive H-EPVS (mean and SD, 0.47 ± 0.54, t = 9.017, P < 0.01). Further analysis shows that in patients with acute lacunar stroke, P300 latency was positively associated with H-EPVS counts (r = 0.726, P = 0.000). H-EPVS counts was negatively associated with cognitive function score (the field of verbal fluency) (r=-0.705, P = 0.000). ROC curve analysis showed that the index of cognitive impairment diagnosed by P300 in patients with acute lacunar stoke was 0.796. Conclusion Extensive H-EPVS has a high incidence in patients with acute lacunar stroke. The P300 latency may be used as an early indicator to evaluate the verbal fluency function of extensive H-EPVS patients with acute lacunar stroke.

P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

2013 ◽  
Vol 44 (10) ◽  
pp. 2151-2162 ◽  
Author(s):  
K. C. Chen ◽  
I. H. Lee ◽  
Y. K. Yang ◽  
S. Landau ◽  
W. H. Chang ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Meta Analysis ◽  
Gender Effect ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Healthy Controls ◽  
Local Study ◽  
Significant Difference ◽  
Drug Naïve

BackgroundReduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.MethodWe explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.ResultsNo overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.ConclusionsOur findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

scholarly journals Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

2021 ◽  
Author(s):  
Gorana Pobric ◽  
Jason R. Taylor ◽  
Hemavathy M. Ramalingam ◽  
Emily Pye ◽  
Louise Robinson ◽  
...  
Keyword(s):  
Working Memory ◽  
Single Gene ◽  
Neurofibromatosis Type ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Group Differences ◽  
Control Group ◽  
P300 Latency ◽  
Memory Impairments

AbstractNeurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.

scholarly journals Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

2010 ◽  
Vol 68 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Caroline Nunes Rocha ◽  
Carmen Silvia Molleis Galego Miziara ◽  
Maria Luiza Giraldes de Manreza ◽  
Eliane Schochat
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Mesial Temporal Sclerosis ◽  
Left Temporal Lobe ◽  
Behavioral Test ◽  
Temporal Lobes ◽  
Laterality Effect

The purpose of this study was to determine the repercussions of left temporal lobe epilepsy (TLE) for subjects with left mesial temporal sclerosis (LMTS) in relation to the behavioral test-Dichotic Digits Test (DDT), event-related potential (P300), and to compare the two temporal lobes in terms of P300 latency and amplitude. We studied 12 subjects with LMTS and 12 control subjects without LMTS. Relationships between P300 latency and P300 amplitude at sites C3A1,C3A2,C4A1, and C4A2, together with DDT results, were studied in inter-and intra-group analyses. On the DDT, subjects with LMTS performed poorly in comparison to controls. This difference was statistically significant for both ears. The P300 was absent in 6 individuals with LMTS. Regarding P300 latency and amplitude, as a group, LMTS subjects presented trend toward greater P300 latency and lower P300 amplitude at all positions in relation to controls, difference being statistically significant for C3A1 and C4A2. However, it was not possible to determine laterality effect of P300 between affected and unaffected hemispheres.

scholarly journals Effect of Single Administration of Mulberry Milk on the Cognitive Function of 6–12-Year-Old Children: Results from a Randomized, Placebo-Controlled, Crossover Study

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Wipawee Thukham-mee ◽  
Jintanporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Panakaporn Wannanon
Keyword(s):  
Working Memory ◽  
Cognitive Function ◽  
Response Time ◽  
Cognitive Processing ◽  
Critical Role ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
School Age Children ◽  
Enhancing Effect ◽  
Saliva Cortisol

Currently, cognitive enhancers are considered necessary because they play a critical role in daily and social behaviors. The cognitive-enhancing effect of mulberry milk has gained attention due to the cognitive-enhancing effect of this anthocyanin-rich substance and the cognitive-enhancing effect of mulberry fruit in animal models. However, the effect of anthocyanin-rich mulberry milk in clinical trials especially in children is still unknown. This study was a randomized double-blind crossover intervention. A total of forty-six healthy, normal, cognitive subjects aged 6–12 years old were provided mulberry milk (containing mulberry 10 g) or placebo milk (50 mL). Attention and cognitive function were assessed using the auditory odd ball paradigm of event-related potential, whereas working memory was assessed using a computerized battery test. The assessment was performed at baseline and then at 1.5 and 3 hours postdosing. At the end of study period, the activities of acetylcholinesterase (AChE) and monoamine oxidase (MAO) together with that of saliva cortisol were determined. Following mulberry milk intervention, the decreased N100 latency and the increased P300 amplitude were increased both at 1.5 and 3 hours after dosing. The decreased response time of digit updating was observed both at 1.5 and 3 hours after dosing, whereas the decreased response time of picture updating was observed at 3 hours after dosing. In addition, the reduction of saliva cortisol was also observed at both periods. The improvement of attention and cognitive processing capabilities together with the working memory suggests the cognitive-enhancing potential of mulberry milk for school-age children. The possible underlying mechanism may be associated partly with the reduction of cortisol, a stress hormone.

Social and nonsocial cognitive functions in patients with schizophrenia: A comparative neuropsychological and neurophysiological study

2017 ◽  
Vol 41 (S1) ◽  
pp. s817-s817
Author(s):  
M.A. Khalil ◽  
A.A. Saleh ◽  
N.M. El-Fayoumy ◽  
S.M. Gohar
Keyword(s):  
Social Cognition ◽  
Psychiatric Disorders ◽  
Cognitive Deficits ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Psychotic Symptoms ◽  
Control Group ◽  
P300 Latency ◽  
Symptom Scale ◽  
The Mind

BackgroundPatients with schizophrenia suffer from cognitive deficits in seven domains in addition to social cognition. P300 latency and amplitude have been linked in these patients to the basic cognitive deficits.ObjectivesComparing patients suffering from schizophrenia with matched healthy subjects as regards auditory event related potential tests as measured by P300.Subjects and methodsFifty-two subjects were divided into 2 groups: group (A): 27 patients with schizophrenia according to the diagnostic and statistical manual of mental disorders-text revised (DSM-IV TR). Those with current substance use, psychiatric disorders or organic disorders were excluded. Group (B): 25 healthy control subjects with negative history of substance and psychiatric disorders. Patients were assessed using Positive and Negative Symptom Scale (PANSS) for severity of psychotic symptoms, Addenbrook's Cognitive Examination Revised (ACE-R) for basic cognitive, reading the mind in the eye test for social cognition, P300 and electro-encephalography (EEG)ResultsThe two groups were different significantly in ACE total and its subtests measuring attention-orientation, memory, language, visuospatial and reading the mind in the eye test for social cognition scores with patients showing lower scores (P = 0.000, 0.012, 0.000, 0.038, 0.041 and 0.001 respectively). Control group had higher amplitude of P300 and shorter latency than patients (P = 0.003 and 0.005 respectively). P300 amplitude correlated positively with visuospatial memory (P = 0.015). PANSS general pathology scale correlated positively with duration of untreated psychosis (P = 0.029) and with fluency (P = 0.047).ConclusionPatients with schizophrenia differ from controls in P300.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Evaluating a Novel P300-Based Real-Time Image Ranking BCI

2021 ◽  
Vol 3 ◽  
Author(s):  
Ngadhnjim Sutaj ◽  
Martin Walchshofer ◽  
Leonhard Schreiner ◽  
Luca Turchet ◽  
Harald Pretl ◽  
...  
Keyword(s):  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Significant Shift ◽  
Eeg Signal ◽  
Gray Scale ◽  
Eeg Data ◽  
Target Ratio ◽  
Image Ranking ◽  
Unfamiliar Faces

Brain–computer interfaces (BCIs) establish communication between a human brain and a computer or external devices by translating the electroencephalography (EEG) signal into computer commands. After stimulating a sensory organ, a positive deflection of the EEG signal between 250 and 700 ms can be measured. This signal component of the event-related potential (ERP) is called “P300.” Numerous studies have provided evidence that the P300 amplitude and latency are linked to sensory perception, engagement, and cognition. Combining the advances in technology, classification methods, and signal processing, we developed a novel image ranking system called the Unicorn Blondy Check. In this study, the application was tested on 21 subjects using three different visual oddball paradigms. Two consisted of female faces and gray-scale images, while the third test paradigm consisted of familiar and unfamiliar faces. The images were displayed for a duration of 150 ms in a randomized order. The system was trained using 50 trials and tested with 30 trials. The EEG data were acquired using the Unicorn Hybrid Black eight-channel BCI system. These synchronized recordings were analyzed, and the achieved classification accuracies were calculated. The EEG signal was averaged over all participants and for every paradigm separately. Analysis of the EEG data revealed a significant shift in the P300 latency dependent on the paradigm and decreased amplitude for a lower target to non-target ratio. The image ranking application achieved a mean accuracy of 100 and 95.5% for ranking female faces above gray-scale images with ratios of 1:11 and 5:11, respectively. In the case of four familiar faces to 24 unfamiliar faces, 86.4% was reached. The obtained results illustrate this novel system’s functionality due to accuracies above chance levels for all subjects.

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