Neighborhood disorder predicts lower serum vitamin D levels in pregnant African American women: A pilot study

Abstract Objectives To study the nutritional status and prevalence of RBC folate, Serum folate and vitamin D deficiency among adolescents. Methods A cross sectional pilot study was carried out among 96 adolescents visiting outpatient department for refraction at tertiary care hospital in North India. Anthropometric data was obtained for height in centimetres and weight in kilograms. A pretested questionnaire was used to capture quantitative data. Venous blood samples were collected where red blood cell (RBC), serum folate and serum Vitamin D concentrations were measured. Anaemia was defined as normal, mild, moderate and severe as Hb > 12gm/dl, 11–11.9 gm/dl, 8–10.9 gm/dl and < 8 gm/dl respectively. Serum folate deficiency was defined as serum folate < 7 nmol/l, and RBC folate deficiency and insufficiency were defined as RBC folate < 305 nmol/l and & < 748 nmol/l, respectively. Vitamin D deficiency, insufficiency and sufficiency was defined as 25(OH)D < 20 ng/ml, 20–29 ng/ml and ≥ 30 ng/ml respectively. Descriptive statistics and inferential statistics were used. Results Almost 46% of adolescents were malnourished (10.4% were underweight, 35.4% were overweight or obese) and mean BMI was 19.7 kg/meter2 however it did not differ significantly across gender. As compared to boys more girls were vegetarian by diet. The mean concentrations for Hb, serum folate and RBC folate were 12.7 (95% CI: 12.4, 13.0) gm/dl, 15.1 (95% CI 12.5, 17.7) nmol/L and 492.9 (95% CI 431.9, 553.9) nmol/L, respectively. Mean concentration for Hb was significantly different across gender (p – 0.0). Around 17% of adolescents were anaemic, 60% were deficient for serum folate and 79% were deficient for RBC folate. Mean serum vitamin D levels were 18 ng/dl (95% CI: 17.0, 22.3) no significant difference found across gender. A total of 62.5% were deficient and 28% were insufficient for vitamin D (ng/ml). Around 50% of the adolescents lack adequate sleep (<8 hours) and increase vitamin D levels were associated with increase sleep duration (r-0.02, p-0.02). Conclusions The nutritional status of adolescents in this study is poor and reflects a need to conduct a community-based study which can help in planning strategies to improve nutritional status during critical period of adolescence Funding Sources nil. Supporting Tables, Images and/or Graphs

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Serum Vitamin D Levels in Patients with Myelodysplastic Syndromes: A Retrospective Single-Center Analysis

Acta Haematologica ◽

10.1159/000496014 ◽

2019 ◽

Vol 141 (4) ◽

pp. 225-231

Author(s):

Catharina Müller-Thomas ◽

Heinz Tüchler ◽

Martina Rudelius ◽

Heike Schneider ◽

Sabrina Pfefferkorn ◽

...

Keyword(s):

Vitamin D ◽

Myelodysplastic Syndromes ◽

Lower Risk ◽

Serum Vitamin ◽

Innate Immune ◽

International Prognostic Scoring System ◽

Lower Serum ◽

Serum Vitamin D ◽

Disease Characteristics ◽

Vitamin D Levels

Background/Aims: There is growing evidence supporting the role of innate immune deregulation and inflammation in the pathogenesis of myelodysplastic syndromes (MDS). Vitamin D (VD) is known to be involved in various immune and epigenetic processes. This analysis aimed to evaluate serum VD levels in patients with MDS and to analyze associations between serum VD levels and disease characteristics. Methods: Serum levels of 25-hydroxyvitamin D3 (25(OH)-D3), the major form of VD in human serum, were measured by chemiluminescence immunoassay in 62 unselected patients with MDS. Associations between serum 25(OH)-D3 levels and disease characteristics were analyzed using Kendall’s tau and two-sided p values. Results: The median serum 25(OH)-D3 level was markedly reduced (17.5 ng/mL). Patients with lower-risk disease features had lower serum 25(OH)-D3 levels than patients with higher-risk disease features with regard to medullary blast counts (16 vs. 31 ng/mL, p < 0.001), the revised international prognostic scoring system (13 vs. 30.5 ng/mL, p = 0.001), and blood counts. Conclusions: We show that patients with lower-risk disease characteristics exhibit lower serum VD levels than patients with higher-risk disease characteristics. Whether these findings might reflect innate immune deregulation has to be investigated in further studies.

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Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

10.53350/pjmhs211581896 ◽

2021 ◽

Vol 15 (8) ◽

pp. 1896-1898

Author(s):

Aisha Bashir ◽

Asima Karim ◽

Asia Kanwal ◽

Asma Salam

Keyword(s):

Vitamin D ◽

Cell Biology ◽

Serum Vitamin ◽

Healthy Controls ◽

Healthy Individuals ◽

Lower Serum ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Mean

Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D

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Cardiorespiratory fitness, different measures of adiposity, and serum vitamin D levels in African-American adults

Journal of Investigative Medicine ◽

10.1136/jim-2019-001071 ◽

2019 ◽

Vol 67 (7) ◽

pp. 1087-1090 ◽

Cited By ~ 2

Author(s):

Stephen William Farrell ◽

Laura DeFina ◽

Benjamin Willis ◽

Carolyn E Barlow ◽

Andjelka Pavlovic ◽

...

Keyword(s):

Vitamin D ◽

African American ◽

Cardiorespiratory Fitness ◽

Serum Vitamin ◽

Normal Weight ◽

Positive Trend ◽

Ordered Categories ◽

Men And Women ◽

Serum Vitamin D ◽

Vitamin D Levels

We examined the associations among cardiorespiratory fitness (CRF), adiposity, and serum 25-hydroxyvitamin D [25(OH)D) levels in African-American (AA) adults. 468 AA patients from the Cooper Clinic in Dallas, TX were examined between 2007 and 2018. Measures included body mass index (BMI), waist circumference (WC), percent body fat (%fat) via skinfolds, CRF via a maximal treadmill test, and 25(OH)D. Participants were classified by CRF based on age and sex, as well as by clinical categories of adiposity exposures and 25(OH)D. We examined trends of 25(OH)D across CRF and adiposity categories. We calculated OR with 95% CIs for 25(OH)D deficiency across categories of CRF and adiposity measures. We observed a significant positive trend for CRF (p=0.01) and a significant inverse trend for BMI (p=0.005) across ordered 25(OH)D categories. Adjusted mean 25(OH)D levels were higher across ordered CRF categories (p=0.03), and lower across ordered categories of BMI (p=0.02), WC (p=0.03) and %fat (p=0.04). When grouped into categories of fit and unfit (upper 80% and lower 20% of the CRF distribution, respectively), OR for vitamin D deficiency was significantly lower in fit compared with unfit men and women (OR=0.55, 95% CI: 0.35–0.87, p=0.01). Compared with normal weight BMI (referent), ORs for 25(OH)D deficiency were significantly higher for BMI-obese subjects (OR=1.70, 95% CI: 1.00–2.87, p=0.04). 25(OH)D levels are positively associated with CRF and negatively associated with different measures of adiposity in AA men and women. Because of the study design, causal inferences cannot be made and future prospective studies are needed.

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Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes / Povezava Povprečnih Dolžin Telomerov Z Indeksom Telesne Teže in Vitaminom D Pri Mladostnikih S Sladkorno Boleznijo Tipa 1

Slovenian Journal of Public Health ◽

10.1515/sjph-2015-0011 ◽

2015 ◽

Vol 54 (2) ◽

pp. 74-78 ◽

Cited By ~ 1

Author(s):

Tine Tesovnik ◽

Jernej Kovac ◽

Tinka Hovnik ◽

Primoz Kotnik ◽

Tadej Battelino ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Type 1 Diabetes ◽

Serum Vitamin ◽

Serum Levels ◽

Glycated Haemoglobin ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

Abstract Background. Type 1 diabetes (T1D) is an autoimmune chronic disease where hyperglycemia, increased risk of oxidative stress, advanced glycation end-products and other genetic and environmental factors lead to T1D complications. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels. Methods. Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). Body mass index standard deviation score (BMI-SDS), glycated haemoglobin and serum level of vitamin D metabolite (25-(OH)-D3) and the age at the onset of T1D were collected from the available medical documentation. Results. Results indicate shorter ATL in subjects with higher BMI-SDS when compared to those with longer ATL (0.455 ± 0.438, -0.63 ± 0.295; p=0.049). Subjects with higher BMI-SDS had lower serum vitamin D levels when compared to those with lower BMI-SDS (40.66 ± 3.07 vs. 52.86 ± 4.85 nmol/L; p=0.045). Vitamin D serum levels did not significantly differ between subjects with longer/shorter ATL. Conclusion. T1D children/adolescents with shorter ATL tend to have higher BMI-SDS. Lower serum vitamin D levels were associated with higher BMI-SDS, while associations between vitamin D serum levels, age at the onset of T1D, glycated haemoglobin and ATL were not observed. Additional studies with more participants are required to clarify the role of the telomere dynamics in T1D aetiology and development of complications.

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Elderly patients with trochanteric hip fracture have lower serum Vitamin D levels compared to patients with cervical hip fracture

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2010.03.023 ◽

2011 ◽

Vol 52 (1) ◽

pp. e15-e18 ◽

Cited By ~ 7

Author(s):

Olga E. Dretakis ◽

Andrew N. Margioris ◽

Christos Tsatsanis ◽

Konstantin E. Dretakis ◽

Niki Malliaraki ◽

...

Keyword(s):

Vitamin D ◽

Hip Fracture ◽

Elderly Patients ◽

Serum Vitamin ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

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Correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20202113 ◽

2020 ◽

Vol 7 (6) ◽

pp. 971

Author(s):

Divya V. Patil ◽

Tarun Kumar Dutta

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Essential Hypertension ◽

Vitamin D3 ◽

Serum Vitamin ◽

Sunlight Exposure ◽

P Value ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: Vitamin D, a fat-soluble vitamin is produced when ultraviolet rays from sunlight strike the skin. Literature data supports, there is a relationship between low vitamin D and pathogenesis of cardiovascular diseases and arterial hypertension. It had been seen that lower circulating 25(OH)D levels were associated with higher blood pressures. Aim was to study the correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals.Methods: An observational study was conducted on 60 individuals in the OPD at MGMCRI between January 2018 and December 2018. Based on history and blood pressure values (JNC 7), the population was divided into cases and controls in accordance with the age and sex. Serum Vitamin D levels were measured by chemiluminescence assay and classified into deficiency (<20ng/ml), insufficiency (20-30ng/ml) and sufficiency (30-100ng/ml). Statistical analysis was done using independent t test, one way ANOVA and correlation.Results: Among the hypertensive individuals, 90% were Vitamin D deficient and 10% had insufficiency. The mean Serum Vitamin D level in essential hypertension was 14.6±4.401 (p value <0.001). Serum Vitamin D levels were affected significantly by increasing BMI (p value <0.001) and less sunlight exposure (p value <0.001) among both cases and controls. There was also a significant negative correlation between serum vitamin D levels and systolic blood pressure (p <0.001).Conclusions: Isolated systolic hypertension was associated with lower serum Vitamin D levels. Obesity and reduced sunlight exposure are factors associated with lower serum Vitamin D levels.

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Evaluation of serum Vitamin D levels in patients with systemic sclerosis and healthy controls: Results of a pilot study

Indian Dermatology Online Journal ◽

10.4103/idoj.idoj_328_17 ◽

2018 ◽

Vol 9 (4) ◽

pp. 250 ◽

Cited By ~ 6

Author(s):

VikramK Mahajan ◽

Sarita Gupta ◽

RajinderS Yadav ◽

KaraninderS Mehta ◽

Satya Bhushan ◽

...

Keyword(s):

Vitamin D ◽

Systemic Sclerosis ◽

Pilot Study ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Vitamin D Levels

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Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study

Reproductive Biology and Endocrinology ◽

10.1186/s12958-021-00885-z ◽

2022 ◽

Vol 20 (1) ◽

Author(s):

David B. Seifer ◽

Geralyn Lambert-Messerlian ◽

Glenn E. Palomaki ◽

Robert M. Silver ◽

Corette Parker ◽

...

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Maternal Serum ◽

Research Network ◽

Lower Serum ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Control Study

Abstract Background Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental perfusion. Vitamin D plays an important role in pregnancy influencing implantation, angiogenesis and placental development. The objective of this study was to determine whether there is an association between serum vitamin D levels, and anti-angiogenic factors at the time of delivery and the occurrence of preeclampsia. Methods This nested case control study analyzed frozen serum samples at the time of delivery and related clinical data from women with singleton liveborn pregnancies who had participated in studies of the NICHD Stillbirth Collaborative Research Network. Women with a recorded finding of preeclampsia and who had received magnesium sulfate treatment prior to delivery were considered index cases (N = 56). Women without a finding of preeclampsia were controls (N = 341). Results Women with preeclampsia had 14.5% lower serum vitamin D levels than women in the control group (16.5 ng/ml vs. 19 ng/ml, p = 0.014) with 64.5% higher sFlt-1 levels (11,600 pg/ml vs. 7050 pg/ml, p < 0.001) and greater than 2 times higher endoglin levels (18.6 ng/ml vs. 8.7 ng/ml, < 0.001). After controlling for gestational age at delivery and maternal BMI, vitamin D levels were 0.88 times lower (P = 0.051), while endoglin levels were 2.5 times higher and sFlt-1 levels were 2.1 times higher than in control pregnancies (P < 0.001). Conclusions Women with preeclampsia at time of delivery have higher maternal antiangiogenetic factors and may have lower maternal serum vitamin D levels. These findings may lead to a better understanding of the underlying etiology of preeclampsia as well as possible modifiable treatment options which could include assuring adequate levels of maternal serum vitamin D prior to pregnancy.

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