Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes / Povezava Povprečnih Dolžin Telomerov Z Indeksom Telesne Teže in Vitaminom D Pri Mladostnikih S Sladkorno Boleznijo Tipa 1

Abstract Background. Type 1 diabetes (T1D) is an autoimmune chronic disease where hyperglycemia, increased risk of oxidative stress, advanced glycation end-products and other genetic and environmental factors lead to T1D complications. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels. Methods. Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). Body mass index standard deviation score (BMI-SDS), glycated haemoglobin and serum level of vitamin D metabolite (25-(OH)-D3) and the age at the onset of T1D were collected from the available medical documentation. Results. Results indicate shorter ATL in subjects with higher BMI-SDS when compared to those with longer ATL (0.455 ± 0.438, -0.63 ± 0.295; p=0.049). Subjects with higher BMI-SDS had lower serum vitamin D levels when compared to those with lower BMI-SDS (40.66 ± 3.07 vs. 52.86 ± 4.85 nmol/L; p=0.045). Vitamin D serum levels did not significantly differ between subjects with longer/shorter ATL. Conclusion. T1D children/adolescents with shorter ATL tend to have higher BMI-SDS. Lower serum vitamin D levels were associated with higher BMI-SDS, while associations between vitamin D serum levels, age at the onset of T1D, glycated haemoglobin and ATL were not observed. Additional studies with more participants are required to clarify the role of the telomere dynamics in T1D aetiology and development of complications.

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Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes

Hormone Research in Paediatrics ◽

10.1159/000475711 ◽

2017 ◽

Vol 87 (6) ◽

pp. 385-395 ◽

Cited By ~ 3

Author(s):

Debika Nandi-Munshi ◽

Maryam Afkarian ◽

Kathryn B. Whitlock ◽

Jamie L. Crandell ◽

Ronny A. Bell ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Serum Vitamin ◽

Nutrition Survey ◽

Cross Sectional ◽

Serum Vitamin D ◽

Urine Albumin ◽

Health And Nutrition ◽

Vitamin D Levels

Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6–19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.

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Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case–Control Association Study

Genes ◽

10.3390/genes11080897 ◽

2020 ◽

Vol 11 (8) ◽

pp. 897

Author(s):

Joana T. Almeida ◽

Dircea Rodrigues ◽

Joana Guimarães ◽

Manuel C. Lemos

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Serum Vitamin ◽

Cumulative Effect ◽

P Value ◽

Nucleotide Polymorphisms ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Minor Alleles

Vitamin D has immunomodulatory effects, and its deficiency has been implicated in the autoimmune process of type 1 diabetes. Serum vitamin D levels are influenced by variants in genes involved in the synthesis, transport, hydroxylation and degradation of vitamin D. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) at the DHCR7 (rs12785878), GC (rs2282679), CYP2R1 (rs2060793) and CYP24A1 (rs6013897) loci are associated with type 1 diabetes in the Portuguese population. Genotype and allele frequencies were determined in 350 cases of type 1 diabetes and in 490 controls. The frequency of each SNP alone was not significantly different between patients and controls. However, the combined analysis of the four SNPs showed that minor alleles of these variants clustered more frequently in patients. The proportion of individuals with three or more minor alleles was significantly higher in patients than in controls (56.3% vs. 48.5; odds ratio (OR) 1.37; 95% confidence interval (CI) 1.04–1.81; p-value 0.027). These results suggest a cumulative effect of SNPs at the DHCR7, GC, CYP2R1 and CYP24A1 loci on the susceptibility to type 1 diabetes, due to the roles of these genes in the vitamin D metabolic pathway.

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Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

Pediatric Diabetes ◽

10.1111/j.1399-5448.2012.00890.x ◽

2012 ◽

Vol 14 (1) ◽

pp. 31-41 ◽

Cited By ~ 47

Author(s):

Ristan M Greer ◽

Sharon L Portelli ◽

Betsy Shin-Min Hung ◽

Geoffrey J Cleghorn ◽

Sarah K McMahon ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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Serum Vitamin D Level in Children with Type 1 diabetes mellitus in Duhok city, Iraq

Science Journal of University of Zakho ◽

10.25271/sjuoz.2019.7.1.536 ◽

2019 ◽

Vol 7 (1) ◽

pp. 10-13

Author(s):

Azad A. Haleem

Keyword(s):

Diabetes Mellitus ◽

Body Mass Index ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Body Mass ◽

Serum Vitamin ◽

Duration Of Diabetes ◽

Serum Vitamin D

Type 1 Diabetes Mellitus is an autoimmune disorder that occurs in the Β-cells of pancreatic islets. Vitamin D is essential in maintaining the bone health. It has proven that Vitamin D has an autoimmune disorders including T1DM. Hence, the aim is to detect the prevalence of vitamin D deficiency among children with T1DM. A case control study conducted in Duhok, North of Iraq between 15th of February and 15th of August 2016. 100 enrolled participants aged from 5 to 15 years of both genders were divided in to two groups. Fifty of them had T1DM and 50 children who were healthy and non-diabetic. All participants were studied in terms of age, gender, duration of diabetes, glycemic control (HbA1c) and Body Mass index .Samples of blood were taken to measure serum Vitamin D and HbA1c levels. Mean serum Vitamin D level in diabetic group was 6.068 ±2.45 ng/mL while in the control group it was 21.101 ±9.23 ng/mL. Vitamin D were lower in the diabetic patients than controls (P= 0.01). Vitamin D level was indirectly correlated with duration of diabetes (P=0.01).Level of Vitamin D was decreased with increasing HbA1C (P=0.01). Level of Vitamin D was not significantly related to body mass index. Vitamin D level is not significantly related to body mass index.

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Neighborhood disorder predicts lower serum vitamin D levels in pregnant African American women: A pilot study

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2020.105648 ◽

2020 ◽

Vol 200 ◽

pp. 105648

Author(s):

J. Woo ◽

M.D. Koenig ◽

C.G. Engeland ◽

M.A. Kominiarek ◽

R. White-Traut ◽

...

Keyword(s):

Vitamin D ◽

African American ◽

Pilot Study ◽

African American Women ◽

Serum Vitamin ◽

Neighborhood Disorder ◽

Lower Serum ◽

American Women ◽

Serum Vitamin D ◽

Vitamin D Levels

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No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160173 ◽

2017 ◽

Vol 75 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Soniza Vieira Alves-Leon ◽

Samira L. Apostolos-Pereira ◽

Walter Oleschko Arruda ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Large Population ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Control Subjects ◽

Vitamin D Levels ◽

The Mean ◽

25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

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Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

10.21203/rs.3.rs-323788/v1 ◽

2021 ◽

Author(s):

Jianbo Shu ◽

Xinhui Wang ◽

Mingying Zhang ◽

Xiufang Zhi ◽

Jun Guan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Plasma Glucose ◽

Serum Vitamin ◽

Chinese Children ◽

Serum Vitamin D ◽

Significant Difference

Abstract Objective: Diabetic ketoacidosis is a common complication in children with type 1 diabetes mellitus. The purposes of the present study were to explore clinical correlates of serum vitamin D level in Chinese children with type 1 diabetes.Methods: A total of 143 inpatients (boys/girls = 60/83) were recruited from Tianjin Children’s Hospital. Their demographic and clinical characteristics were collected. These patients were divided into the non-DKA group(n=43) and DKA group(n=100).Results: The positive ZnT8-ab was significantly higher in DKA patients compared with non-DKA patients (p=0.038). There was a negative correlation between plasma glucose and the concentration of vitamin D(r =−0.188, p=0.024), although there was no significant difference in vitamin D between two groups of T1DM patients with or without DKA (p=0.317). The multiple logistic regression revealed that sex(male) and BMI were independent risk factors to predict the deficiency or insufficiency of Vitamin D in T1DM children. When BMI is lower than 16 kg/m2 according to the cut-off value of the ROC curve, it provides some implications of Vitamin D deficiency or insufficiency in TIDM children ( 95%CI:0.534~0.721, P=0.014). Conclusions: Our results suggested that positive ZnT8-ab was associated with a greater risk of DKA at T1DM onset. Additionally, neither vitamin D levels nor the proportion of patients with different levels of vitamin D differed between the two groups inT1DM children with or without DKA. Furthermore, Vitamin D level was negatively correlated with plasma glucose, lower BMI and male children with T1DM were prone to be deficient or insufficient of Vitamin D.

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Serum Vitamin D Level in Children with and without Type 1 Diabetes Mellitus

Journal of Diabetes & Metabolism ◽

10.4172/2155-6156.1000655 ◽

2016 ◽

Vol 07 (03) ◽

Author(s):

Halioui Louhaichi Sonia ◽

Mrabet Ali

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Serum Vitamin ◽

Serum Vitamin D

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Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1209 ◽

2014 ◽

Vol 7 (3) ◽

pp. 112-116

Author(s):

Anil Jain ◽

Pankaj Shah ◽

Datt Modh ◽

Bhaskar Thakkar ◽

Ashish Katarkar ◽

...

Keyword(s):

Vitamin D ◽

Allergic Rhinitis ◽

Normal Population ◽

Serum Vitamin ◽

Serum Levels ◽

Multifactorial Disease ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Immunological Effects ◽

K Deficiency

ABSTRACT Allergic rhinitis is a common condition affecting 5 to 40% of general population and its prevalence is increasing. It is a chronic condition characterized by inflammation of nasal mucosa. As per recent studies, there is an association between serum vitamin D levels and allergic rhinitis status. Vitamin D has major role in the regulation of calcium metabolism. In addition to this, it also has a number of immunological effects and takes part in immunomodulation, which can significantly affect the outcome of allergic responses like in allergic rhinitis. Aims and objectives To establish the correlation between vitamin D3 serum levels and allergic rhinitis. Materials and methods Vitamin D levels were assessed in 23 patients with allergic rhinitis diagnosed clinically by allergic rhinitis and its impact on asthma 2008 criteria and results were compared with vitamin D status in the normal population of same region. Results The levels of serum vitamin D levels were significantly low in the patients of allergic rhinitis. Conclusion Measuring of serum levels of vitamin D could be considered in the routine assessment of patients with allergic rhinitis. How to cite this article Thakkar B, Katarkar A, Modh D, Jain A, Shah P, Joshi K. Deficiency of Vitamin D in Allergic Rhinitis: A Possible Factor in Multifactorial Disease. Clin Rhinol An Int J 2014;7(3):112-116.

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