The association between N-acetylcysteine treatment and hepatic healing in patients with non-acetaminophen-induced liver injury in pediatric intensive care: A single-center retrospective study

Author(s):  
Utku Karaarslan ◽  
Mustafa Çolak ◽  
Sevgi Topal ◽  
Gülhan Atakul ◽  
Ekin Soydan ◽  
...  
2019 ◽  
Vol 38 (11) ◽  
pp. 3015-3023 ◽  
Author(s):  
Yael Haviv-Yadid ◽  
Yulia Segal ◽  
Amir Dagan ◽  
Kassem Sharif ◽  
Nicola Luigi Bragazzi ◽  
...  

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
Gideon Stitt ◽  
Jennifer Morris ◽  
Lindsay Schmees ◽  
Joseph Angelo ◽  
Ayse Akcan Arikan

ABSTRACT This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% fT>1×MIC, with the fourth patient achieving 98% fT>1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.


2020 ◽  
Vol 09 (02) ◽  
pp. 113-118 ◽  
Author(s):  
Sangita Basnet ◽  
Rawan Musaitif ◽  
Aayush Khanal ◽  
Kimberly Powell ◽  
Giovanna Caprirolo ◽  
...  

AbstractA retrospective study was done to determine the effect of potassium (K+) infusions on serum levels in children admitted to the pediatric intensive care unit (PICU) with diabetic ketoacidosis (DKA). Eighty-two percent of 92 cases studied received 40 mEq/L K+ infusion over the treatment period of median 13.0 (interquartile range [IQR]: 7–18) hours. The median K+ value at the end of this period was 3.9 (IQR: 3.4–4.2) mEq/L. There were 31 data points of low K+ values (<3.5 mEq/L) and 4 high values (>5.5 mEq/L) during this treatment period. The K+ infusions of 40 mEq/L may be sufficient to normalize serum K+ when treating DKA.


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