Value of serum ferritin and soluble transferrin receptor for prediction of coronary artery disease and its clinical presentations

Linkage Analysis by a Transmission/Disequilibrium Test of Russian Sibling Pairs with Coronary Artery DiseaseWe studied the association between coronary artery disease (CAD) and polymorphisms of theABCA1, ACE, AGT, eNOSandEFNB3genes in 85 Russian patients with angiography-proven CAD and 100 of their siblings. No gene analyzed had a z-score value of more than 2.47 for CAD or for its main clinical presentations due to sibling transmission/disequilibrium test (S-TDT). However, the DD genotype ofACEis significantly more prevalent in siblings with CAD [p= 0.025, relative risk(RR)2.8], angina (p= 0.028,RR= 3.3) and myocardial infarction (MI) (p= 0.018,RR= 5.5). An increased risk of CAD, and its main manifestations, was associated with the R1587 allele of theABCA1gene: theRRfor developing CAD was 4.88, for MI 6.18, and for angina 3.69 for siblings who were carriers of the R1587R and R1587K genotypes. Index of stenosis was significantly higher in probands with the K219K and R219K genotypes (p= 0.001). The combination of genotype K219K with R219K was more frequent among siblings with CAD (p= 0.044,RR= 2.38), arterial hypertension (p= 0.023,RR= 2.87) and angina (p= 0.027,RR= 3.3). Thus, none of the genes studied can be considered as the main gene associated with CAD. However, the insertion/deletion (I/D) polymorphism of theACEgene and the R219K and R1587K variants ofABCA1are associated with a higher likelihood of developing CAD, MI and angina among Russians who have siblings affected by CAD.

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Association of serum ferritin with coronary artery disease

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2012.06.013 ◽

2012 ◽

Vol 45 (16-17) ◽

pp. 1336-1341 ◽

Cited By ~ 4

Author(s):

Yunping Zhou ◽

Tongtao Liu ◽

Changwei Tian ◽

Peipei Kang ◽

Chongqi Jia

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Serum Ferritin ◽

Artery Disease

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Serum concentration of soluble adhesive molecules in patients with different forms of coronary artery disease

Vojnosanitetski pregled ◽

10.2298/vsp0904265d ◽

2009 ◽

Vol 66 (4) ◽

pp. 265-270 ◽

Cited By ~ 3

Author(s):

Goran Damnjanovic ◽

Marija Jelic ◽

Boris Djindjic ◽

Stevan Ilic

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Angina Pectoris ◽

Serum Concentration ◽

Markers Of Inflammation ◽

Clinical Presentations ◽

Inflammatory Processes ◽

History Of ◽

Artery Disease ◽

Adhesive Molecules

Background/Aim. Vascular cell adhesion molecules-1 (VCAM-1) and intercellular cell adhesive molecules-1 (ICAM- 1) play an important role in developing and progression of coronary atherosclerosis. The aim of the paper was to compare concentrations of soluble forms of VCAM-1 and ICAM-1 in patients with different clinical presentations of coronary artery disease (CAD) and patients without CAD. Methods. Blood samples were taken from 25 patients with acute myocardial infarction (AMI), 25 patients with unstable angina pectoris (UAP), 25 with stable angina pectoris (SAP) and from 15 control patients without CAD, and concentrations of solubile adhesive molecules (VCAM-1, ICAM-1) were determined. Results. Obesity was more prominent in the NAP than in the SAP and the control patients (p < 0.05). There were no significant differences in gender distribution, age, duration of the CAD and body mass index between the groups. Hypertension and diabetes mellitus type 2 were more frequent in the CAD patients than in the controls (p < 0.01). Family history of the CAD was more frequent in the AMI and the UAP group than in the controls (p < 0.05). Serum concentrations of VCAM-1 was similar in the patients with AMI (955.9 ? 117.8 ng/mL), UAP (952.4 ? 139.1 ng/mL) and SAP (931 ? 169.8 ng/mL), and significantly higher in these groups compared with the controls (823.4 ? 97.6; p < 0.05, p < 0.05 and p < 0.1 respectively). Serum concentration of ICAM-1 was similar in the patients with AMI (699.2?125.6 ng/mL), UAP (727.6?171.8 ng/mL) and SAP (697.5?165.6 ng/mL), and significantly higher in these groups compared with the controls (583.4 ? 86.6; p < 0.1, p < 0.05 and p < 0.1 respectively). Conclusion. Increased concentrations of VCAM-1 and ICAM-1, as markers of inflammation, showed the importance of inflammatory processes in development of atherosclerosis and clinical expression of CAD. Measurement of soluble ICAM-1 and VCAM-1 concentrations is a useful indicator of atherosclerosis presence but not severity of CAD clinical presentation.

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