The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice

2006 ◽  
Vol 189 (2) ◽  
pp. 282-287 ◽  
Author(s):  
Paul Nestel ◽  
Akihiko Fujii ◽  
Terri Allen
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Hdl Cholesterol ◽  
Plasma Triglyceride ◽  
Aortic Atherosclerosis ◽  
Deficient Mice

scholarly journals Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster

1999 ◽  
Vol 82 (4) ◽  
pp. 309-317 ◽  
Author(s):  
Emile A. M. de Deckere ◽  
Johan M. M. van Amelsvoort ◽  
Gerald P. McNeill ◽  
Penny Jones
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Hdl Cholesterol ◽  
Liver Weight ◽  
Peroxisome Proliferation ◽  
Lipid Levels ◽  
Fat Pad ◽  
Active Isomer ◽  
Carnitine Acetyl Transferase ◽  
Cla Isomers

Effects of the conjugated linoleic acid (CLA) isomers cis-9, trans-11 (c9, t11 CLA) and trans-10, cis-12 (t10, c12 CLA) on lipid metabolism and markers of peroxisome proliferation were investigated in hamsters fed on purified diets containing 30 % energy as fat and 0·1 g cholesterol/kg for 8 weeks. Four groups (n 32 each) received diets without CLA (control), with a mixture of equal amounts of c9, t11 and t10, c12 CLA (CLA mix), with c9, t11 CLA, and with t10, c12 CLA. The total amount of CLA isomers was 1·5 % energy or 6·6 g/kg diet. CLA was incorporated into glycerides and exchanged for linoleic acid in the diet. Compared with the control, the CLA mix and t10, c12 CLA decreased fasting values of LDL- (21 and 18 % respectively) and HDL-cholesterol (8 and 11 %), increased VLDL-triacylglycerol (80 and 61 %), and decreased epididymal fat pad weights (9 and 16 %), whereas c9, t11 CLA had no significant effects. All CLA preparations increased liver weight, but not liver lipids. However, the increase in liver weight was much less in the c9, t11 CLA group (8 %) than in the other two groups (25 %) and might have been caused by the small amount of t10, c12 CLA present in the c9, t11 CLA preparation. Liver histology revealed that increased weight was due to hypertrophy. Markers of peroxisome proliferation, such as cyanide-insensitive palmitoyl CoA oxidase (EC 1.3.3.6) and carnitine acetyl transferase (EC 2.3.1.7) activities, were not increased by CLA. Both c9, t11 CLA and t10, c12 CLA were incorporated into phospholipids and triacylglycerols, but t10, c12 CLA only about half as much as c9, t11 CLA. In addition, linoleic acid and linolenic acid concentrations were lower in lipids of the t10, c12 CLA group compared with the c9, t11 CLA group. These data suggest that t10, c12 CLA stimulated the oxidation of all C18 polyunsaturated fatty acids. The results indicate that the t10, c12 CLA isomer, and not the so-called natural CLA isomer (c9, t11), is the active isomer affecting lipid levels in hamsters.

scholarly journals Liver Carbohydrate and Lipid Metabolism of Insulin-Deficient Mice Is Altered by trans-10, cis-12 Conjugated Linoleic Acid

2009 ◽  
Vol 139 (10) ◽  
pp. 1901-1907 ◽  
Author(s):  
Tony Jourdan ◽  
Louiza Djaouti ◽  
Laurent Demizieux ◽  
Joseph Gresti ◽  
Bruno Vergès ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Carbohydrate And Lipid Metabolism ◽  
Deficient Mice

Co-Administration of Nitrite and Conjugated Linoleic Acid Attenuates Cardiac Dysfunction in Leptin Deficient Mice

2011 ◽  
Vol 51 ◽  
pp. S38
Author(s):  
Kellianne M. Piell ◽  
Sonia R. Salvatore ◽  
Gustavo Bonacci ◽  
Francisco J. Schopfer ◽  
Marsha P Cole
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cardiac Dysfunction ◽  
Deficient Mice

scholarly journals A cis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

2005 ◽  
Vol 289 (2) ◽  
pp. H652-H659 ◽  
Author(s):  
Karine Valeille ◽  
Jacqueline Férézou ◽  
Ghislaine Amsler ◽  
Annie Quignard-Boulangé ◽  
Michel Parquet ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Fish Oil ◽  
Conjugated Linoleic Acid ◽  
Milk Fat ◽  
Oxidized Ldl ◽  
Hdl Cholesterol ◽  
Peroxisome Proliferator ◽  
Butter Oil ◽  
Cholesterol Ratio ◽  
Amyloid A

Conjugated linoleic acid (CLA) mixtures demonstrated antiatherogenic properties in several animal models, including hamsters, but the mechanism of action of the main food-derived CLA isomer is unknown in this species. This study thus focused on cis-9, trans-11-CLA (rumenic acid), and its effect was compared with that of fish oil, which is known to influence several aspects of atherogenesis. Syrian hamsters were fed (for 12 wk) diets containing 20% (wt/wt) butter fat (B diet) or the same diet augmented with either 1% (wt/wt) of a cis-9, trans-11-CLA-rich oil (BR diet) or 1% (wt/wt) fish oil (BF diet). The BR diet induced the lowest aortic lipid deposition (from −30% to −45%) among the butter oil-fed hamsters. In this group, plasma also displayed a reduced non-HDL-to-HDL-cholesterol ratio (21% less than in the butter oil group) and inflammatory serum amyloid A levels (70–80%) and an improvement of anti-oxidized LDL paraoxonase activity (all P < 0.05). Compared with the B group, the beneficial effects of the BR diet could be further explained in part by preventing the high VCAM-1 expression rate, increasing (30%) ATP-binding cassette subfamily A1 expression in the aorta, and downregulating expression of inflammatory-related genes (TNF-α, IL-1β, and cyclooxygenase 2, 2- to 2.8-fold, P < 0.05). This effect was partly associated with an activation of peroxisome proliferator-activating receptor (PPAR)/liver X receptor (LXR)-α signaling cascade. Interestingly, activation of PPAR/LXR-α signaling was not observed in hamsters fed the BF diet, in which the early signs of atherogenesis were increased. In conclusion, this study demonstrated that milk fat-rich cis-9, trans-11-CLA reduces the atherogenic process in hyperlipidemic hamsters.

Maternal consumption of conjugated linoleic acid improves tolerance to glucose and hdl-cholesterol in the rat progeny

2020 ◽  
Vol 11 (10) ◽  
pp. 9075-9085
Author(s):  
Michelly Pires Queiroz ◽  
Martiniano da Silva Lima ◽  
Marília Ferreira Frazão Tavares de Melo ◽  
Rita de Cássia Ramos do Egypto Queiroga ◽  
Rui José Branquinho Bessa ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Hdl Cholesterol ◽  
Metabolic Changes ◽  
Pregnancy And Lactation ◽  
Maternal Consumption ◽  
Different Levels

Our study evaluates the impacts of maternal consumption of different levels of CLA during pregnancy and lactation on physical and metabolic changes in the rat progeny.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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