Galectin-3, a marker of cardiac remodeling, is inversely associated with serum levels of marine OMega-3 fatty acids

Polyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine the effects of probiotics and omega 3 fatty acids on serum polyamine levels in colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, colitis treated by probiotics (VSL#3), colitis treated by omega-3, and colitis treated by both probiotics and omega-3. Experimental colitis was induced by injection of 200 mg/kg 2,4-Dinitrobenzenesulfonic acid (DNBS). The probiotic and the omega-3 fatty acid supplements were applied daily by oral gavage. Serum polyamine levels were measured with high performance liquid chromatography (HPLC). In each group, the levels of serum polyamines are the highest in spermidine and the least in spermine. Bowel inflammation in experimentally induced colitis mice resulted in lower serum polyamine concentrations. In probiotic and omega 3 fatty acid supplemented group significant decreases were observed for spermine and spermidine (p<0.001), while no significant changes were obtained for putrescine. Combined supplementation of probiotics and omega-3 fatty acids for 10 days in colitis mice significantly decreased the serum levels of spermine and spermidine.

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Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma

Cytokine ◽

10.1016/j.cyto.2016.06.002 ◽

2016 ◽

Vol 85 ◽

pp. 61-66 ◽

Cited By ~ 9

Author(s):

Shirin Farjadian ◽

Mozhgan Moghtaderi ◽

Mehdi Kalani ◽

Tahereh Gholami ◽

Saeed Hosseini Teshnizi

Keyword(s):

Fatty Acids ◽

Serum Levels ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

T Helper ◽

Children With Asthma

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Omega-3 fatty acids and in vitro fertilzation: do serum levels affect outcomes?

Fertility and Sterility ◽

10.1016/j.fertnstert.2015.07.688 ◽

2015 ◽

Vol 104 (3) ◽

pp. e218

Author(s):

A.M. Eskew ◽

K. Wormer ◽

M. Papadakis ◽

H. Norton ◽

M.C. Elliot ◽

...

Keyword(s):

Fatty Acids ◽

Serum Levels ◽

Omega 3 Fatty Acids ◽

Omega 3

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Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors

Nutrients ◽

10.3390/nu13093050 ◽

2021 ◽

Vol 13 (9) ◽

pp. 3050

Author(s):

Ching-Kun Chang ◽

Po-Ku Chen ◽

Chia-Ching Chen ◽

Shih-Hsin Chang ◽

Chu-Huang Chen ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Fatty Acids ◽

Kinase Inhibitors ◽

Serum Levels ◽

Pain Reduction ◽

Janus Kinase ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Janus Kinase Inhibitors ◽

Lipid Metabolites

Although Janus kinase inhibitors (JAKi) could reduce patient-reported pain in rheumatoid arthritis (RA), their mechanism remains unclear. Therefore, we examined lipid metabolites change in JAKi-treated patients and evaluate their association with pain reduction. We used 1H-NMR-based lipid/metabolomics to determine serum levels of lipid metabolites at baseline and week 24 of treatment. Serum levels of significant lipid metabolites were replicated by ELISA in 24 JAKi-treated and 12 tocilizumab-treated patients. Pain was evaluated with patients’ assessment on a 0-100mm VAS, and disease activity assessed using DAS28. JAKi or tocilizumab therapy significantly reduced disease activity. Acceptable pain (VAS pain ≤20) at week 24 was observed in 66.7% of JAKi-treated patients, and pain decrement was greater than tocilizumab-treated patients (ΔVAS pain 70.0 vs. 52.5, p = 0.0595). Levels of omega-3 fatty acids and docosahexaenoic acid (DHA) were increased in JAKi-treated patients (median 0.55 mmol/L versus 0.71 mmol/L, p = 0.0005; 0.29 mmol/L versus 0.35 mmol/L, p = 0.0004; respectively), which were not observed in tocilizumab-treated patients. ELISA results showed increased DHA levels in JAKi-treated patients with acceptable pain (44.30 µg/mL versus 45.61 µg/mL, p = 0.028). A significant association of pain decrement with DHA change, not with DAS28 change, was seen in JAKi-treated patients. The pain reduction effect of JAKi probably links to increased levels of omega-3 fatty acids and DHA.

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Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial

Psychiatry Research ◽

10.1016/j.psychres.2020.112911 ◽

2020 ◽

Vol 287 ◽

pp. 112911 ◽

Cited By ~ 5

Author(s):

Jana Trebatická ◽

Zuzana Hradečná ◽

Anna Surovcová ◽

Barbora Katrenčíková ◽

Irina Gushina ◽

...

Keyword(s):

Fatty Acids ◽

Depressive Disorder ◽

Controlled Trial ◽

Serum Levels ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Double Blind ◽

Omega 6

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Nutrition Review: Diet, Nutrition, and Osteoarthritis

American Journal of Lifestyle Medicine ◽

10.1177/1559827607302033. ◽

2007 ◽

Vol 1 (4) ◽

pp. 260-263 ◽

Cited By ~ 1

Author(s):

Kathleen J. Melanson

Keyword(s):

Fatty Acids ◽

Serum Levels ◽

Overweight And Obesity ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Dietary Recommendations ◽

Initial Weight Loss ◽

Prevention And Treatment ◽

Omega 6 ◽

Nutrition Review

Despite abundant lay claims regarding diet, nutrients, and osteoarthritis (OA), scientific study on these relationships is in its early stages. The strongest risk factor for OA, particularly of the knee, is overweight and obesity. Initial weight loss studies for the treatment of OA have shown promising results, but longer-term trials are needed. Potential roles of specific nutrients in OA prevention and treatment are under study, but to date, results are somewhat less clear. The ratio of dietary omega-6 to omega-3 fatty acids has been proposed to be related to OA because they are precursors of proinflammatory and anti-inflammatory eicosanoids and cytokines, respectively. However, human data are lacking to substantiate this relationship. Low serum levels of some vitamins, such as C and D, have been associated with OA in epidemiological research, but much more work must be conducted to understand the roles of these and other vitamins in OA prevention and treatment. Biological plausibility exists for the protective properties of antioxidants against OA, so continued research to assist in making specific dietary recommendations with respect to these is needed for OA patients. As the study of diet, nutrients, and OA evolves, it is prudent for practitioners to stay abreast of the research so that they can address patients' questions and recommend diets with adequate omega-3 fatty acids, vitamins, minerals, and antioxidants while avoiding megadoses.

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