Relationships Between Finnish Diabetes Risk Score (Findrisc) And Cardiometabolic Risk Factors In Kyrgyz Native Subjects

Background: Diabetes mellitus (DM) is considered as one of the major health problems worldwide. The rising prevalence of type 2 diabetes mellitus (T2DM) in Bangladesh is primarily attributed to rapid urbanization and associated changes in lifestyle, such as sedentary lifestyle, higher calorie food intake and stressful life. Studies support the utilization of riskassessment scoring systems in quantifying individual’s risk for developing T2DM. Thus, a simple risk-assessment scoring system for early screening of T2DM among Bangladeshi adults will be beneficial to identify the high-risk adults and thus taking adequate preventive measures in combating DM.The purpose of the study was to calculate the risk assessment score of developing T2DM within 10 years among Bangladeshi adults. Methods: The cross-sectional observational study was carried out in the outpatient department (OPD) of Medicine, MARKS Medical College & Hospital, a tertiary care hospital in Dhaka, Bangladesh from February 2018 to July 2018 among randomly sampled 205 adult subjects. Subjects undiagnosed with diabetes mellitus and had previous history of high blood glucose during pregnancy or other health examination (i.e. impaired fasting glucose, impaired glucose tolerance or gestational diabetes mellitus) were included. From a review of literature regarding risk factors of developing DM in Bangladesh, the Finnish Diabetes Risk Score (FINDRISC) system was found to be more useful for the Bangladeshi adults. The Finnish Diabetes Risk Score (FINDRISC) questionnaire was used to collect the data including demographic characteristics and different risk factors and to calculate total risk score for predicting the risk of developing T2DM within 10 years. Results: Among 205 subjects, male and female were 57.1% and 42.9% respectively. The Mean (±SD) age of the study subjects was 37.64±1.07 years. In this study, both non-modifiable and modifiable risk factors showed statistically significant association with the FINDRISC among Bangladeshi adults (p<0.05). There was a significant association among FINDRISC with history of previous high blood glucose, and treated hypertensive Bangladeshi adults.33.65% of the Bangladeshi adults had slightly elevated diabetes risk score (DRS). This study predicts that 17.55% of the Bangladeshi adults may have moderate to high risk to develop T2DM within the consecutive 10 years. Conclusion: This study provides a simple, feasible, non-invasive and convenient screening FINDRISC tool that identifies individuals at risk of having T2DM. People with high risk of DM should be referred for early intervention and changes to a healthy lifestyle and primary prevention to prevent or delay the onset of T2DM. Birdem Med J 2020; 10(1): 40-47

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Associations of Serum Folate and Holotranscobalamin With Cardiometabolic Risk Factors in Rural and Urban Cameroon

Current Developments in Nutrition ◽

10.1093/cdn/nzab053_051 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 1058-1058

Author(s):

Camille Mba ◽

Albert Koulman ◽

Stephen Sharp ◽

Nita Forouhi ◽

Fumiaki Imamura ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Score ◽

Cardiometabolic Risk ◽

B Vitamins ◽

Cardiometabolic Risk Factors ◽

Serum Folate ◽

Metabolic Risk ◽

Inverse Association ◽

Metabolic Risk Score

Abstract Objectives Previous studies mostly in Western populations suggest that a low exposure to B-vitamins (folate and vitamin B12 in particular) are associated with increased cardiometabolic disease risk. This study aimed to examine the association of blood concentrations of folate and holotranscobalamin (holoTC) with cardiometabolic risk factors in adults in Cameroon. Methods We conducted a cross-sectional population-based study in 497 adults. We measured serum folate and holoTC by liquid chromatography tandem mass spectrometry and “sandwich” ELISA respectively. Total folate was calculated excluding the oxidation product 5-methyltetrahydrofolate. The outcomes were individual cardiometabolic risk factors and a continuous metabolic risk score. We fitted linear regression models to examine the association between B-vitamins and cardiometabolic risk factors and estimated β-coefficients and 95% confidence intervals per standard deviation (SD) difference in each B vitamin variable. Results Mean age was 38.2 (SD: 8.6) years and 63.5% of the participants were women. Mean serum folate was 15.9 (SD: 10.8) nmol/L and holoTC was 74.1 (SD: 33.7) pmol/L. Rural residents had higher concentrations of serum folate but lower holoTC than urban residents. There was a significant inverse association between serum folate and the metabolic risk score (−0.22 (−0.41 to −0.03)) in a multivariable model adjusted for age, sex, education level, smoking, alcohol intake, rural/urban site and BMI. This association was attenuated to the null after further adjustments for objectively measured physical activity (PAEE) and holoTC. HoloTC was positively associated with the metabolic risk score in unadjusted analysis (0.29 (0.08 to 0.51)) but attenuated to the null after adjusting for socio-demographic characteristics. For individual risk factors, an inverse association was observed between serum folate and diastolic blood pressure, which was unaffected by adjustment for confounders including PAEE and holoTC (−1.18 (−2.16 to − 0.20)). Conclusions In Cameroon, serum folate and holoTC were associated with the metabolic risk score in opposite directions, partly depending on potential demographic and socioeconomic characteristics. The inverse association between serum folate and the metabolic risk score was likely driven by the blood pressure component. Funding Sources None.

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Cluster Analysis And Risk Score Calculation Of Surrogate Markers Of Vascular Health, And Their Association With Cardiometabolic Risk Factors In A Healthy Young Adults

Atherosclerosis ◽

10.1016/j.atherosclerosis.2019.06.578 ◽

2019 ◽

Vol 287 ◽

pp. e191

Author(s):

P. Pettersson-Pablo ◽

T.K. Nilsson ◽

Y. Cao ◽

L. Breimer ◽

A. Hurtig-Wennlöf

Keyword(s):

Risk Factors ◽

Cluster Analysis ◽

Young Adults ◽

Risk Score ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Surrogate Markers ◽

Vascular Health

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Diabetes Risk Score in a Young Student Population in Jordan: A Cross-Sectional Study

Journal of Diabetes Research ◽

10.1155/2017/8290710 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Abdel-Ellah Al-Shudifat ◽

Amjad Al-Shdaifat ◽

Ahmad Ali Al-Abdouh ◽

Mohammad Ibrahim Aburoman ◽

Sara Mohammad Otoum ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Risk Score ◽

Plasma Glucose ◽

Risk Group ◽

High Risk Group ◽

Student Population ◽

Diabetes Risk ◽

Young Student ◽

Diabetes Risk Score

Background. The Middle East is the home to the most obese population in the world, and type 2 diabetes mellitus is endemic in the region. However, little is known about risk factors for diabetes in the younger age groups. Methods. The Finnish Diabetes Risk Score (FINDRISC) is a simple, validated tool to identify persons at risk of diabetes. We investigated students at Hashemite University in Jordan with FINDRISC and measured fasting plasma glucose in those who were categorized in the high-risk group. Results. Overall, 1821 students (881 [48.4%] female) were included in the study. Risk factors for diabetes were common: 422 (23.2%) were overweight or obese and 497 (27.3%) had central obesity. Using the FINDRISC score, 94 (5.2%) students were at moderate risk and 32 (1.8%) at high risk of diabetes. The mean FINDRISC score was significantly higher in men than women (5.9 versus 5.4; p=0.002). Twenty-eight students in the high-risk group had a subsequent plasma glucose measurement, and 8 (29%) of them fulfilled the diagnostic criteria for diabetes. Conclusions. Risk factors for diabetes were common in a young student population in Jordan, suggesting that preventive measures should be initiated early in adulthood to turn the diabetes epidemic in the region.

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Validation of the Finnish diabetes risk score (FINDRISC) for the Caucasian population of Siberia

Diabetes Mellitus ◽

10.14341/dm200418-10 ◽

2016 ◽

Vol 19 (2) ◽

pp. 113-118 ◽

Cited By ~ 3

Author(s):

Svetlana V. Mustafina ◽

Oksana D. Rymar ◽

Olga V. Sazonova ◽

Liliya V. Shcherbakova ◽

Michail I. Voevoda

Keyword(s):

Risk Factors ◽

High Risk ◽

Risk Score ◽

Adult Population ◽

Risk Groups ◽

Diabetes Risk ◽

Receiver Operating Curve ◽

Siberian Population ◽

Cross Sectional ◽

Diabetes Risk Score

Aim. A validation of the Finnish diabetes risk score (FINDRISC) was conducted among the Siberian population. FINDRISC was used to study the prevalence of risk factors for type 2 diabetes mellitus (T2DM) and to estimate the incidence of T2DM in high-risk groups during a 10-year observation period. Materials and methods. A total of 9,360 subjects aged between 45 and 69 years were enrolled in this cross-sectional, population-based study. FINDRISC was used to group 8,050 people without diabetes according to their risk for T2DM. Statistical analysis was performed using SPSS. Results. When a cutoff point of 11 was used to identify those with diabetes, sensitivity was 76. 0% and specificity was 60. 2%. The area under the receiver operating curve for diabetes was 0. 73 (0. 73 for men and 0. 70 for women). More than one-third (31. 7%) of the adult population of Novosibirsk was estimated to have medium, high or very high risk of developing T2DM in the next 10 years. Cases of T2DM estimated to occur during the 10 years of follow-up had significantly higher incidence of risk factors such as BMI ≥30 kg/m2, waist circumference 102 cm in men and 88 cm in women and a family history of T2DM and were more likely to take drugs to lower blood pressure. Conclusion. FINDRISC provided good results in our sample, and we recommend its use in the Siberian population.

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Speed of Movement, Fatness, and the Change in Cardiometabolic Risk Factors in Children

International Journal of Sports Medicine ◽

10.1055/a-1308-2924 ◽

2021 ◽

Author(s):

Xianwen Shang ◽

Yanping Li ◽

Haiquan Xu ◽

Qian Zhang ◽

Ailing Liu ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

High Density Lipoprotein ◽

Body Fat ◽

Risk Score ◽

High Density Lipoprotein Cholesterol ◽

Cardiometabolic Risk ◽

Density Lipoprotein ◽

Cardiometabolic Risk Factors ◽

Percent Body Fat

AbstractWe aimed to examine speed of movement and its interactive association with fatness to changes in cardiometabolic risk factors over one year in children. The analysis included 8345 children aged 6–13 years. Cardiometabolic risk score was computed by summing Z-scores of waist circumference, the average of systolic and diastolic blood pressure, fasting glucose, high-density lipoprotein cholesterol (multiplied by −1), and triglycerides. Both high baseline and improvement in speed of movement were associated with favourable changes in percent body fat, lipids, and cardiometabolic risk score. Percentages of the association between baseline speed of movement and changes in cardiometabolic risk score, triglycerides, and high-density lipoprotein cholesterol explained by baseline BMI were 24.6% (19.6–29.1%), 26.2% (19.7–31.1%), and 12.5% (9.6–15.4%), respectively. The corresponding number for percent body fat was 47.0% (40.4–54.1%), 43.3% (36.7–51.7%), and 29.8% (25.0–34.6%), respectively. Speed of movement mediated the association between fatness and cardiometabolic risk factors. Improved speed of movement was associated with a lower increase in blood pressure in obese children only. Speed of movement is a strong predictor of changes in cardiometabolic risk factors. Fatness and speed of movement are interactively associated with cardiometabolic risk factors. Speed of movement may attenuate the positive association between fatness and blood pressure.

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