Exploring the relationship between biomechanical stresses and coronary atherosclerosis

2020 ◽  
Vol 302 ◽  
pp. 43-51
Author(s):  
James N. Cameron ◽  
Ojas H. Mehta ◽  
Michael Michail ◽  
Jasmine Chan ◽  
Stephen J. Nicholls ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
The Relationship

The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis

2011 ◽  
Vol 144 (1-3) ◽  
pp. 436-444 ◽  
Author(s):  
Yahya Islamoglu ◽  
Osman Evliyaoglu ◽  
Ebru Tekbas ◽  
Habib Cil ◽  
Mehmet Ali Elbey ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Serum Levels ◽  
The Relationship

The Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis

2017 ◽  
Vol 49 (5S) ◽  
pp. 156
Author(s):  
Vincent L. Aengevaeren ◽  
Arend Mosterd ◽  
Thijs L. Braber ◽  
Niek HJ Prakken ◽  
Paul D. Thompson ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
The Relationship ◽  
Lifelong Exercise

The relationship between coronary atherosclerosis and body fat distribution measured using dual energy X-ray absorptiometry

2016 ◽  
Vol 248 ◽  
pp. 190-195 ◽  
Author(s):  
Se-Jun Park ◽  
Hyoung-Mo Yang ◽  
Kyoung-Woo Seo ◽  
So-Yeon Choi ◽  
Byoung-Joo Choi ◽  
...  
Keyword(s):  
Body Fat ◽  
Coronary Atherosclerosis ◽  
Fat Distribution ◽  
Dual Energy ◽  
Body Fat Distribution ◽  
X Ray ◽  
The Relationship

scholarly journals The Relationship Between Nutrition and Atherosclerosis

2021 ◽  
Vol 9 ◽  
Author(s):  
Taotao Wei ◽  
Junnan Liu ◽  
Demei Zhang ◽  
Xiaomei Wang ◽  
Guangling Li ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Coronary Atherosclerosis ◽  
Nutritional Intervention ◽  
Pathological Process ◽  
Prevention Strategy ◽  
Omega 3 ◽  
Research Results ◽  
Nutrition Science ◽  
The Relationship

Atherosclerosis is the basic pathological process of many diseases, such as coronary atherosclerosis and stroke. Nutrients can affect the occurrence and development of atherosclerosis. At present, in nutrition science, the research on atherosclerosis focuses on which nutrients play an important role in its prevention strategy, and what are the possible mechanisms of its action. In the current study, the process of atherosclerosis can be affected by adjusting the proportion of nutrients in the diet. In this review, we pay attention to the effects of phytosterols, omega-3-polyunsaturated fatty acids, polyphenol, vitamin, and other nutrients on atherosclerosis, pay attention to their current epidemiological status, current nutritional research results, and prevention or a possible mechanism to reduce the risk of development of atherosclerosis. So that more personalized nutritional approaches may be more effective in terms of nutritional intervention responses to atherosclerosis.

Abstract 684: Changes in Levels of High Density Lipoprotein Cholesterol Predict the Impact of Torcetrapib on Progression of Coronary Atherosclerosis: Insights from ILLUSTRATE

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Stephen J Nicholls ◽  
Danielle M Brennan ◽  
Kathy Wolski ◽  
Srinivasa R Kalidindi ◽  
Keon-Woong Moon ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Single Coronary Artery ◽  
Rate Of Progression ◽  
Atorvastatin Therapy ◽  
Atheroma Volume ◽  
The Impact ◽  
The Relationship

Background: Administration of the CETP inhibitor torcetrapib does not slow the rate of progression of coronary atherosclerosis. The reason for the lack of therapeutic efficacy remains unknown. This analysis investigated the relationship between changes in HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) and atheroma volume in patients treated with torcetrapib. Methods: 910 patients with angiographic coronary artery disease underwent IVUS imaging within a single coronary artery before and during 24 months of treatment with torcetrapib (n = 464) or placebo (n = 446) on a background of atorvastatin therapy. The relationship between changes in levels of HDL-C and LDL-C and both percent atheroma volume (PAV) and total atheroma volume (TAV) was evaluated in patients treated with torcetrapib. Results: Administration of torcetrapib raised HDL-C by 61% and lowered LDL-C by 20% when compared to atorvastatin alone. An inverse relationship was observed between changes in HDL-C and both PAV (r = −0.17, p < 0.001) and TAV (r = −0.17, p < 0.001). Patients with the highest level of HDL-C (> 87 mg/dL) had the lowest rate of progression of PAV (−0.7 v +0.7%, p = 0.0003) and TAV (−9.2 v −4.6 mm 3 , p = 0.09). The greatest elevation in level of HDL-C (> 80%) was associated with the lowest progression of PAV (−0.3 v +0.9%, p = 0.002) and TAV (−12.6 v −3.4 mm 3 , p = 0.0006). Patients undergoing regression (any reduction in PAV) had greater absolute levels (73 v 66 mg/dL, p = 0.02) and changes (59.5 v 48.3%, p = 0.02) of HDL-C. No difference in the impact of torcetrapib on changes in PAV (+0.3 v +0.1%, p = 0.34) and TAV (−9.1 v −9.3 mm 3 , p = 0.95) was observed in patients with baseline levels below or above 40 mg/dL. No relationship was observed between changes in LDL-C and either PAV (r = 0.06, p = 0.20) or TAV (r = 0.07, p = 0.12) in torcetrapib treated patients. On multivariate analysis, changes in levels of HDL-C independently predicted the impact of torcetrapib on progression of PAV (p = 0.007) and TAV (p = 0.004). Conclusion: Increasing levels of HDL-C from torcetrapib treatment were associated with a beneficial impact of torcetrapib on plaque progression. This is consistent with the generation of functional HDL particles and suggests other effects to be responsible for the lack of benefit of torcetrapib.

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