Effect of vitamin D status on lipid profile in premenopausal women with hypothyroidism

Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.

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A 6-month “self-monitoring” lifestyle modification with increased sunlight exposure modestly improves vitamin D status, lipid profile and glycemic status in overweight and obese Saudi adults with varying glycemic levels

Lipids in Health and Disease ◽

10.1186/1476-511x-13-87 ◽

2014 ◽

Vol 13 (1) ◽

Cited By ~ 7

Author(s):

Nasser M Al-Daghri ◽

Hanan Alfawaz ◽

Naji J Aljohani ◽

Yousef Al-Saleh ◽

Kaiser Wani ◽

...

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Lifestyle Modification ◽

Sunlight Exposure ◽

Vitamin D Status ◽

Glycemic Status ◽

Self Monitoring

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Vitamin D status, sun exposure and lipid profile among adolescents living in São Paulo, Brazil

The FASEB Journal ◽

10.1096/fasebj.27.1_supplement.1060.4 ◽

2013 ◽

Vol 27 (S1) ◽

Author(s):

Kelly Virecoulon Giudici ◽

Mariana Agostinho Pádua Lopes ◽

Dirce Maria Lobo Marchioni ◽

Regina Mara Fisberg ◽

Lígia Araújo Martini

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Sun Exposure ◽

Sao Paulo ◽

São Paulo ◽

Vitamin D Status

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ASSOСIATION BETWEEN VITAMIN D STATUS AND METABOLIC DISORDERS IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE HYPOTHYROID DISEASE

Wiadomości Lekarskie ◽

10.36740/wlek202107111 ◽

2021 ◽

Vol 74 (7) ◽

pp. 1612-1616

Author(s):

Oksana O. Chukur ◽

Nadiya V. Pasyechko ◽

Anzhela O. Bob ◽

Iryna V. Smachylo ◽

Liudmyla V. Radetska

Keyword(s):

Vitamin D ◽

Negative Correlation ◽

Metabolic Disorders ◽

Premenopausal Women ◽

Thyroid Peroxidase ◽

Healthy Population ◽

Vitamin D Status ◽

Thyrotropic Hormone ◽

Autoimmune Thyroid ◽

Vitamin D Levels

The aim: Is to establish a relationship between serum vitamin D level with carbohydrate and lipid indexes in women with autoimmune hypothyroid disease. Materials and methods: 146 women with autoimmune hypothyroid disease were examined in the period 2017-2019, who signed the informed consent. The mean age of women was 43.8 ± 0.7 years. Anthropometric, general clinical and biochemical examinations were performed including determination of lipid metabolism, hydrocarbon metabolism and establishment of vitamin-D status. Results: Vitamin D deficiency was found in 78.8%, insufficiency in 17.1% of women with autoimmune hypothyroidism. Statistical processing of results was carried out and established strong negative correlation between 25 (OH) D and Thyroid Peroxidase Antibody (r = -0,77) and thyrotropic hormone level (r = -0.72), р<0,05. Strong inverse correlations were found between vitamin D levels and body mass index (r=-0,74) and total cholesterol levels (r=-0,72), negative correlation of medium strength was with highdensity lipoprotein cholesterol (r=-0,58), triglycerides (r=-0,46), atherogenic coefficient (r=-0,65) and the HOMA-IR (r=-0,57), The values of p < 0.05 were considered reliable. Conclusions: The incidence of vitamin D hypovitaminosis in women with autoimmune thyroid disease is significantly higher than in the healthy population. Low vitamin D status is significantly associated with autoimmune thyroid dysfunction and determines the degree of metabolic disorders and cardiovascular risk in premenopausal women with autoimmune hypothyroid disease.

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Knowledge and attitudes about vitamin D and sunlight exposure in premenopausal women living in Jeddah, and their relationship with serum vitamin D levels

Journal of Health Population and Nutrition ◽

10.1186/s41043-021-00263-w ◽

2021 ◽

Vol 40 (1) ◽

Author(s):

Tahani A. Zareef ◽

Robert T. Jackson

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Odds Ratio ◽

Premenopausal Women ◽

Sun Exposure ◽

Sunlight Exposure ◽

Vitamin D Status ◽

Saudi Women ◽

Vitamin D Intake ◽

Insufficient Knowledge

Abstract Background Saudi women are at risk of vitamin D deficiency because they are fully covered by traditional clothing and because of their indoor lifestyle. The latest national study reported that vitamin D deficiency (serum 25(OH)D < 50 nmol/L) affects 72% of young Saudi women. Because little information is available regarding knowledge on vitamin D, attitudes toward sun exposure, and the vitamin D status of premenopausal women in Jeddah, more research is necessary in order to develop effective intervention programs. The purpose of this study is to explore how the relationship between knowledge of vitamin D and attitudes about sun exposure affect the serum 25(OH)D levels in premenopausal Saudi women. Methods This cross-sectional study included 257 women aged 20–50 years attending the primary care clinic in Jeddah, Saudi Arabia. Participants completed questionnaires about socio-demographics, dietary vitamin D intake, attitudes toward sun exposure, and were tested on their knowledge of vitamin D. Serum 25(OH)D was evaluated using chemiluminescent microparticle immunoassay. Results Although 99% of participants had heard of vitamin D and 91% knew that sunlight exposure is a primary source of vitamin D, they also expressed the feeling of having insufficient knowledge regarding vitamin D sources. Furthermore, the majority of participants had negative attitudes toward sun exposure. High fish consumption was associated with a higher level of knowledge regarding vitamin D. The binary logistic regression indicated that low levels of knowledge about vitamin D were associated with low education levels (odds ratio = 0.397, 95% CI = [0.206, 0.765], p = 0.019) and with being married (odds ratio = 0.522, 95% CI = [0.281, 0.971], p = 0.04). In addition, spending time outside in the sun was significantly associated with increased serum 25(OH)D levels (p = 0.006), and the wearing of colored abaya was significantly associated with increased serum 25(OH)D levels (p = 0.008). Conclusion Suboptimal vitamin D status and insufficient knowledge of vitamin D intake sources are common in premenopausal women in Jeddah. Based on this data, health professionals could provide medical intervention to the most vulnerable female patients, as well as offer clear guidelines and information to the general public.

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Dyslipidemia and Vitamin D Status in Diabetic Patients

International Journal of Current Science Research and Review ◽

10.47191/ijcsrr/v5-i1-07 ◽

2022 ◽

Vol 05 (01) ◽

Author(s):

Mohammed Sassi ◽

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Vitamin D Deficiency ◽

Elevated Serum ◽

Female Gender ◽

Serum Levels ◽

Vitamin D Supplementation ◽

Diabetic Patients ◽

Vitamin D Status ◽

Cross Sectional

Background: Dyslipidemia is one of the most common metabolic syndrome among diabetic patients due to several factors include insulin insufficiency, resistance, and central obesity. Furthermore both vitamin D deficiency and diabetes are most public health worldwide problems. Therefore the aim of the present work to study the dyslipidemia and vitamin D status in diabetes patients and also to study the relation between vitamin D status and lipid profile in diabetic patients. Methods: A Cross sectional study conducted on randomly selected diabetic patients whether have vitamin D deficiency with dyslipidemia, vitamin D deficiency with no dyslipidemia or dyslipidemia with no vitamin D deficiency. A total sample 165 patients enrolled in the study with serum lipid profile, vitamin D and glycemic control measured at beginning and end of the study. The data analysis was done through Chi-square or T test at α< 0.05. Result: The data collected on 165 patients revealed that, patients aged 41-60 years were most common, and female gender was twice as male. This study include both types of diabetes with vitamin D deficiency and dyslipidemia or vitamin D deficiency with no dyslipidemia or dyslipidemia with not vitamin D deficiency as control. Therefore, the result of this work confirmed that vitamin D deficiency significant implicated in elevated serum levels of TG, TC, LDL, VLDL, FPG and HbA1C (P< 0.05). However, vitamin D deficiency has linked to slight increased serum HDL levels. In compared to man, vitamin D deficiency linked significantly to dyslipidemia and abnormal high levels blood glucose and HbA1C par in women. Conclusion: The present study revealed that, vitamin D deficiency associated negatively with serum levels of TC, TG, VLDL, LDL, FPG and HbA1C whereas the deficiency of vitamin D linked to elevated HDL levels. In gender distribution lower vitamin D values associated with elevated serum FPG, HbA1C, lipid profile with exception HDL in women. The data of this study suggested that, diabetic patients with dyslipidemia may improve their lipid profile and glucose hemostasis through vitamin D supplementation

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