scholarly journals Transcriptional analysis of gasoline engine exhaust particulate matter 2.5-exposed human umbilical vein endothelial cells reveals the different gene expression patterns related to the cardiovascular diseases

2022 ◽  
Vol 29 ◽  
pp. 101190
Author(s):  
Inkyo Jung ◽  
Minhan Park ◽  
Myong-Ho Jeong ◽  
Kihong Park ◽  
Won-Ho Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gasoline Engine ◽  
Umbilical Vein ◽  
Expression Patterns ◽  
Transcriptional Analysis ◽  
Gene Expression Patterns ◽  
Engine Exhaust ◽  
Umbilical Vein Endothelial Cells ◽  
Particulate Matter 2.5 ◽  
Exhaust Particulate

scholarly journals Differential MicroRNA Profiling in a Cellular Hypoxia Reoxygenation Model upon Posthypoxic Propofol Treatment Reveals Alterations in Autophagy Signaling Network

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Zhuo Chen ◽  
Zhe Hu ◽  
Zhiqi Lu ◽  
Shuyun Cai ◽  
Xiaoxia Gu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mirna Expression ◽  
Umbilical Vein ◽  
Expression Patterns ◽  
Global Perspective ◽  
Genome Wide ◽  
Cellular Hypoxia ◽  
Umbilical Vein Endothelial Cells ◽  
Microrna Microarray ◽  
Hypoxia Reoxygenation

Recent studies indicate that propofol may protect cells via suppressing autophagic cell death caused by excessive reactive oxygen species induced by hypoxia reoxygenation (H/R). It is established that gene expression patterns including autophagy-related genes changed significantly during the process of H/R in the presence or absence of propofol posthypoxia treatment (P-PostH). The reasons for such differences, however, remain largely unknown. MicroRNAs provide a novel mechanism for gene regulation. In the present study, we systematically analyzed the alterations in microRNA expression using human umbilical vein endothelial cells (HUVECs) subjected to H/R in the presence or absence of posthypoxic propofol treatment. Genome-wide profiling of microRNAs was then conducted using microRNA microarray. Fourteen miRNAs are differentially expressed and six of them were validated by the quantitative real-time PCR (Q-PCR) of which three were substantially increased, whereas one was decreased. To gain an unbiased global perspective on subsequent regulation by altered miRNAs, predicted targets of ten miRNAs were analyzed using the Gene Ontology (GO) analysis to build signaling networks. Interestingly, six of the identified microRNAs are known to target autophagy-related genes. In conclusion, our results revealed that different miRNA expression patterns are induced by propofol posthypoxia treatment in H/R and the alterations in miRNA expression patterns are implicated in regulating distinctive autophagy-related gene expression.

Gene expression patterns in blood predict future severe endpoints in community acquired pneumonia

Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S8-S9
Author(s):  
M Bauer ◽  
H Kirsten ◽  
E Grunow ◽  
P Ahnert ◽  
M Kiehntopf ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Patterns ◽  
Community Acquired Pneumonia ◽  
Gene Expression Patterns
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