scholarly journals Discovery of cell-internalizing artificial nucleic acid aptamers for lung fibroblasts and targeted drug delivery

2020 ◽  
Vol 105 ◽  
pp. 104321
Author(s):  
Hiro Uemachi ◽  
Yuuya Kasahara ◽  
Keisuke Tanaka ◽  
Takumi Okuda ◽  
Yoshihiro Yoneda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Targeted Drug Delivery ◽  
Lung Fibroblasts ◽  
Nucleic Acid Aptamers ◽  
Targeted Drug

scholarly journals Nucleic Acid Aptamers as a Potential Nucleus Targeted Drug Delivery System

2020 ◽  
Vol 17 (2) ◽  
pp. 101-111 ◽  
Author(s):  
Garima Shrivastava ◽  
Hamid A. Bakshi ◽  
Alaa A. Aljabali ◽  
Vijay Mishra ◽  
Faruck L. Hakkim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drug Delivery ◽  
Nucleic Acid ◽  
Targeted Drug Delivery ◽  
Comprehensive Description ◽  
Nucleic Acid Aptamers ◽  
Dna And Rna ◽  
Site Of Action ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Background: Nucleus targeted drug delivery provides several opportunities for the treatment of fatal diseases such as cancer. However, the complex nucleocytoplasmic barriers pose significant challenges for delivering a drug directly and efficiently into the nucleus. Aptamers representing singlestranded DNA and RNA qualify as next-generation highly advanced and personalized medicinal agents that successfully inhibit the expression of certain proteins; possess extraordinary gene-expression for manoeuvring the diseased cell's fate with negligible toxicity. In addition, the precisely directed aptamers to the site of action present a tremendous potential to reach the nucleus by escaping the ensuing barriers to exhibit a better drug activity and gene expression. Objective: This review epigrammatically highlights the significance of targeted drug delivery and presents a comprehensive description of the principal barriers faced by the nucleus targeted drug delivery paradigm and ensuing complexities thereof. Eventually, the progress of nucleus targeting with nucleic acid aptamers and success achieved so far have also been reviewed. Method: Systematic literature search was conducted of research published to date in the field of nucleic acid aptamers. Conclusion: The review specifically points out the contribution of individual aptamers as the nucleustargeting agent rather than aptamers in conjugated form.

scholarly journals Nucleic Acid Aptamers: Research Tools in Disease Diagnostics and Therapeutics

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Baby Santosh ◽  
Pramod K. Yadava
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Cancer Diagnosis ◽  
Targeted Drug Delivery ◽  
Present Review ◽  
Targeted Therapeutics ◽  
High Affinity ◽  
Nucleic Acid Aptamers ◽  
Disease Diagnostics ◽  
Targeted Drug

Aptamers are short sequences of nucleic acid (DNA or RNA) or peptide molecules which adopt a conformation and bind cognate ligands with high affinity and specificity in a manner akin to antibody-antigen interactions. It has been globally acknowledged that aptamers promise a plethora of diagnostic and therapeutic applications. Although use of nucleic acid aptamers as targeted therapeutics or mediators of targeted drug delivery is a relatively new avenue of research, one aptamer-based drug “Macugen” is FDA approved and a series of aptamer-based drugs are in clinical pipelines. The present review discusses the aspects of design, unique properties, applications, and development of different aptamers to aid in cancer diagnosis, prevention, and/or treatment under defined conditions.

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