scholarly journals Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

2022 ◽  
Vol 146 ◽  
pp. 112610
Author(s):  
Md. Tanvir Kabir ◽  
Md. Habibur Rahman ◽  
Muddaser Shah ◽  
Mohd. Raeed Jamiruddin ◽  
Debasish Basak ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Anti Inflammatory

scholarly journals REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

2021 ◽  
pp. 91-94
Author(s):  
KRISHNENDU P. R. ◽  
ARJUN B. ◽  
VIBINA K. ◽  
NIVEA CLEO T. S. ◽  
DRISYA N. K. ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Symptomatic Relief ◽  
Drug Repurposing ◽  
Epidemiological Studies ◽  
Neuroprotective Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Cost

Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity.

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

2018 ◽  
Vol 153 ◽  
pp. 105-115 ◽  
Author(s):  
Carmela Spagnuolo ◽  
Stefania Moccia ◽  
Gian Luigi Russo
Keyword(s):  
Neurodegenerative Disorders ◽  
Anti Inflammatory

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

2020 ◽  
Vol 16 ◽  
Author(s):  
Papagiouvannis Georgios ◽  
Theodosis-Nobelos Panagiotis ◽  
Kourounakis N. Panos ◽  
Rekka A. Eleni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Acetylcholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Nootropic Agents ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

Background: Alzheimer’s Disease (AD) is one of the most common neurodegenerative disorders, characterized by memory deficits and cognitive impairment. Acetylcholinesterase inhibitors, NMDA receptor antagonists and nootropic agents are used clinically, but they have only symptomatic efficacy, attributed to the multifactorial character of AD. The multi-target directed compound approach is gaining attention and has been under investigation lately. Objective: This review selects several research articles, which describe the design, synthesis and biological evaluation of multi-targeting molecules combining antioxidant or/and anti-inflammatory properties. Compounds with these properties are expected to be beneficial in the treatment of AD. Methods: This review summarizes the pathobiochemistry of AD, as well as the role of oxidative stress and inflammation in the progression of neurodegeneration. It presents novel compounds with antioxidant or/and anti-inflammatory activity, that have been tested for their efficacy in neurodegenerative disorders. Results: Various researchers have taken advantage of the multi-targeting drug approach, in order to design molecules which may be developed to useful agents for the treatment of neurodegeneration.

scholarly journals Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Joseph Vamecq ◽  
Pierre Andreoletti ◽  
Riad El Kebbaj ◽  
Fatima-Ezzahra Saih ◽  
Norbert Latruffe ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Physiological Role ◽  
Nordihydroguaiaretic Acid ◽  
Health And Wellness ◽  
Argan Oil ◽  
Aging Properties ◽  
Acyl Coa Oxidase ◽  
Anti Inflammatory

To clarify appropriateness of current claims for health and wellness virtues of argan oil, studies were conducted in inflammatory states. LPS induces inflammation with reduction of PGC1-α signaling and energy metabolism. Argan oil protected the liver against LPS toxicity and interestingly enough preservation of peroxisomal acyl-CoA oxidase type 1 (ACOX1) activity against depression by LPS. This model of LPS-driven toxicity circumvented by argan oil along with a key anti-inflammatory role attributed to ACOX1 has been here transposed to model aging. This view is consistent with known physiological role of ACOX1 in yielding precursors of specialized proresolving mediators (SPM) and with characteristics of aging and related disorders including reduced PGC1-α function and improvement by strategies rising ACOX1 (via hormonal gut FGF19 and nordihydroguaiaretic acid in metabolic syndrome and diabetes conditions) and SPM (neurodegenerative disorders, atherosclerosis, and stroke). Delay of aging to resolve inflammation results from altered production of SPM, SPM improving most aging disorders. The strategic metabolic place of ACOX1, upstream of SPM biosynthesis, along with ability of ACOX1 preservation/induction and SPM to improve aging-related disorders and known association of aging with drop in ACOX1 and SPM, all converge to conclude that ACOX1 represents a previously unsuspected and currently emerging antiaging protein.

scholarly journals Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1022 ◽  
Author(s):  
Fiona Limanaqi ◽  
Francesca Biagioni ◽  
Federica Mastroiacovo ◽  
Maico Polzella ◽  
Gloria Lazzeri ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Neurodegenerative Disorders ◽  
Potential Role ◽  
Protective Mechanisms ◽  
Neuroprotective Effects ◽  
Mitochondrial Homeostasis ◽  
Naturally Occurring ◽  
Anti Inflammatory ◽  
Target Effects

Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.

scholarly journals Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory Properties

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 970
Author(s):  
Gonçalo Garcia ◽  
Teresa Faria Pais ◽  
Paula Pinto ◽  
Gary Dobson ◽  
Gordon J. McDougall ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Ellagic Acid ◽  
Inflammatory Cytokine ◽  
Degradation Products ◽  
Chronic Neuroinflammation ◽  
Tnf Α ◽  
Dietary Components ◽  
Anti Inflammatory ◽  
Neuroprotective Actions ◽  
Anti Inflammatory Cytokine

Chronic neuroinflammation associated with neurodegenerative disorders has been reported to be prevented by dietary components. Particularly, dietary (poly)phenols have been identified as having anti-inflammatory and neuroprotective actions, and their ingestion is considered a major preventive factor for such disorders. To assess the relation between (poly)phenol classes and their bioactivity, we used five different raspberry genotypes, which were markedly different in their (poly)phenol profiles within a similar matrix. In addition, gastro-intestinal bio-accessible fractions were produced, which simulate the (poly)phenol metabolites that may be absorbed after digestion, and evaluated for anti-inflammatory potential using LPS-stimulated microglia. Interestingly, the fraction from genotype 2J19 enriched in ellagitannins, their degradation products and ellagic acid, attenuated pro-inflammatory markers and mediators CD40, NO, TNF-α, and intracellular superoxide via NF-κB, MAPK and NFAT pathways. Importantly, it also increased the release of the anti-inflammatory cytokine IL-10. These effects contrasted with fractions richer in anthocyanins, suggesting that ellagitannins and its derivatives are major anti-inflammatory (poly)phenols and promising compounds to alleviate neuroinflammation

Insights into amyloid disease from fly models

2014 ◽  
Vol 56 ◽  
pp. 69-83 ◽  
Author(s):  
Ko-Fan Chen ◽  
Damian C. Crowther
Keyword(s):  
Drosophila Melanogaster ◽  
Neurodegenerative Disorders ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Disease Pathogenesis ◽  
Amyloid Aggregates ◽  
Aβ Amyloid ◽  
Polypeptide Chains ◽  
Amyloid Diseases

The formation of amyloid aggregates is a feature of most, if not all, polypeptide chains. In vivo modelling of this process has been undertaken in the fruitfly Drosophila melanogaster with remarkable success. Models of both neurological and systemic amyloid diseases have been generated and have informed our understanding of disease pathogenesis in two main ways. First, the toxic amyloid species have been at least partially characterized, for example in the case of the Aβ (amyloid β-peptide) associated with Alzheimer's disease. Secondly, the genetic underpinning of model disease-linked phenotypes has been characterized for a number of neurodegenerative disorders. The current challenge is to integrate our understanding of disease-linked processes in the fly with our growing knowledge of human disease, for the benefit of patients.

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