Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

AbstractCortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprised 22,822 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the United Kingdom Biobank. Significant associations were replicated in the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium, and their biological implications explored using bioinformatic annotation and pathway analyses. We identified genetic heterogeneity between cortical measures and brain regions, and 161 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There was enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

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Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

Molecular Psychiatry ◽

10.1038/s41380-018-0079-4 ◽

2018 ◽

Vol 24 (12) ◽

pp. 1920-1932 ◽

Cited By ~ 15

Author(s):

Jordi Merino ◽

Hassan S. Dashti ◽

Sherly X. Li ◽

Chloé Sarnowski ◽

Anne E. Justice ◽

...

Keyword(s):

Meta Analysis ◽

European Ancestry ◽

Macronutrient Intake ◽

Aging Research ◽

Genomic Epidemiology ◽

Genome Wide

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Nature Communications ◽

10.1038/s41467-020-18367-y ◽

2020 ◽

Vol 11 (1) ◽

Author(s):

Edith Hofer ◽

◽

Gennady V. Roshchupkin ◽

Hieab H. H. Adams ◽

Maria J. Knol ◽

...

Keyword(s):

Sonic Hedgehog ◽

Genetic Correlations ◽

Brain Regions ◽

Aging Research ◽

Genomic Epidemiology ◽

Discovery Sample ◽

Genome Wide ◽

Psychiatric Conditions ◽

Development And Aging ◽

The Uk

Abstract Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

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Habituation Theory and Environment-Aging Research: Ennui to Joie De Vivre?

The International Journal of Aging and Human Development ◽

10.2190/928t-njk9-142r-ay06 ◽

1989 ◽

Vol 29 (4) ◽

pp. 241-257 ◽

Cited By ~ 1

Author(s):

Carolyn Norris-Baker ◽

Rick J. Scheidt

Keyword(s):

Older People ◽

Psychological Control ◽

Long Term Care ◽

Aging Research ◽

Term Care ◽

Targeted Interventions ◽

Situational Characteristics ◽

The Social ◽

The Impact

Robert Kastenbaum posits that functional aging results in the overadaptation to our own routines and expectations, producing “hyperhabituation,” mental stagnation, and novaphobic response orientations. This article examines the promise and implications of this notion for two areas of environment-aging research: psychological control and environmental comprehension. Possible causal and mediating links between control and habituation are considered, as well as the impact of habituation on environmental perception, cognition, and appraisal. Personal and situational characteristics of older people likely to be at risk for habituated responses are suggested. The article also speculates about individually- and environmentally-targeted interventions which might prevent and/or ameliorate tendencies toward hyperhabituated responses among older people who reside in highly ritualized and constant environments such as long-term care institutions. Interventions subject to future evaluations include modifications for the social, physical, and policy milieux and desensitization of novaphobic responses.

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