Resting EEG spectral slopes are associated with age-related differences in information processing speed

2022 ◽  
pp. 108261
Author(s):  
A. Pathania ◽  
M.J. Euler ◽  
M. Clark ◽  
R. Cowan ◽  
K. Duff ◽  
...  
2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9510-9510 ◽  
Author(s):  
Florence Joly ◽  
Marie Lange ◽  
Natacha Heutte ◽  
Aurélie Daireaux ◽  
Chantal Rieux ◽  
...  

9510 Background: Cognitive deficits (CD) were reported among patients receiving chemotherapy (CT) for cancer, but could also be observed before treatment. Elderly patients were poorly studied although they are more prone to present age-related CD and CD onset or enhancement during CT. This study assessed baseline cognitive functions among elderly localized breast cancer (LBC) patients before adjuvant treatment therapy. Methods: Episodic memory, working memory, executive functions and information processing speed were assessed with neuropsychological tests. Validated questionnaires were used to assess subjective CD, anxiety, depression and fatigue before adjuvant treatment. Geriatric assessment was also realized. Objective CD were defined as a score less than 1.5 standard deviation (SD) of normative data on >2 tests, or less than two SDs on >1 test. Significant subjective CD (evaluated by the FACT-Cog) were defined when the 4 subscales below the first tercile distribution. Results: Results concern 123 elderly LBC (71±4 years): planned treatment included CT and radiotherapy (RT) for 61 patients and RT only for 62 patients. Characteristics are as follows: mastectomy (28%), stage (I: 60%, II: 27%, III: 13%), positive hormonal receptor (88%) and positive Her2 (17%). Before any adjuvant treatment, objective CD were observed in 40% of patients (46% in CT group, episodic memory mainly impaired and 37% in RT group, executive functions and information processing speed mainly impaired). No relation was observed between cancer stage, geriatric frailty and objective CD. Twenty nine percents of patients presented fatigue, 6% anxiety and 10% depression. These variables were not related to objective CD but they were related to subjective CD. Conclusions: More than 40% of elderly LBC patients presented objective CD before any adjuvant therapy that is higher than observed among younger patients. It is important to take account in the decision making of adjuvant treatment in elderly patients. Clinical trial information: NCT01333735.


2021 ◽  
pp. 1-13
Author(s):  
Elisabeth Maria van Zutphen ◽  
Judith Johanna Maria Rijnhart ◽  
Didericke Rhebergen ◽  
Majon Muller ◽  
Martijn Huisman ◽  
...  

Background: Sex differences in cognitive functioning in old age are known to exist yet are still poorly understood. Objective: This study examines to what extent differences in cardiovascular risk factors and cardiovascular disease between men and women explain sex differences in cognitive functioning. Methods: Data from 2,724 older adults from the Longitudinal Aging Study Amsterdam were used. Information processing speed and episodic memory, measured three times during six years of follow-up, served as outcomes. The mediating role of cardiovascular risk factors and cardiovascular disease was examined in single and multiple mediator models. Determinant-mediator effects were estimated using linear or logistic regression, and determinant-outcome and mediator-outcome effects were estimated using linear mixed models. Indirect effects were estimated using the product-of-coefficients estimator. Results: Women scored 1.58 points higher on information processing speed and 1.53 points higher on episodic memory. Several cardiovascular risk factors had small mediating effects. The sex difference in information processing speed was mediated by smoking, depressive symptoms, obesity, and systolic blood pressure. The sex difference in episodic memory was mediated by smoking, physical activity, and depressive symptoms. Effects of smoking, LDL cholesterol, and diabetes mellitus on information processing speed differed between men and women. Conclusion: Differences in cardiovascular risk factors between women and men partially explained why women had better cognitive functioning. A healthy cardiovascular lifestyle seems beneficial for cognition and sex-specific strategies may be important to preserve cognitive functioning at older age.


1983 ◽  
Vol 6 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Marie-Germaine Pecheux ◽  
Roger Lécuyer

If rate of habituation reflects information processing speed and is a stable individual characteristic, fast habituators should habituate relatively quickly to any stimulus, and slow habituators relatively slowly. Moreover, rate of habituation should be related to the baby's tendency to explore in any common situation. To examine these inferences, 24 four-month-old infants were habituated to four stimuli (two geometric patterns and two faces) successively, in two sessions, and observed in a free-exploration situation. The number of trials required to reach criterion in the habituation situations were not correlated, but total looking times to criterion were. Also, slow habituators stayed in the exploration situation for a relatively longer time and also explored a new toy for a longer time. Methodological aspects of habituation are discussed, and an interpretation of habituation sequences in terms of cognitive style is suggested.


Brain ◽  
2005 ◽  
Vol 128 (9) ◽  
pp. 2034-2041 ◽  
Author(s):  
Niels D. Prins ◽  
Ewoud J. van Dijk ◽  
Tom den Heijer ◽  
Sarah E. Vermeer ◽  
Jellemer Jolles ◽  
...  

2014 ◽  
Vol 21 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Jeroen Van Schependom ◽  
Marie B D’hooghe ◽  
Krista Cleynhens ◽  
Mieke D’hooge ◽  
Marie-Claire Haelewyck ◽  
...  

Background: Cognitive impairment affects half of the multiple sclerosis (MS) patient population and is an important contributor to patients’ daily activities. Most cognitive impairment studies in MS are, however, cross-sectional or/and focused on the early disease stages. Objective: We aim to assess the time course of decline of different cognitive domains. Methods: We collected neuropsychological data on 514 MS patients to construct Kaplan-Meier survival curves of the tests included in the Neuropsychological Screening Battery for MS (NSBMS) and the Symbol Digit Modalities Test (SDMT). Cox-proportional hazard models were constructed to examine the influence of MS onset type, age at onset, gender, depression and level of education on the time course, expressed as age or disease. Results: Survival curves of tests focusing on information processing speed (IPS) declined significantly faster than tests with less specific demands of IPS. Median age for pathological decline was 56.2 years (95% CI: 54.4–58.2) on the SDMT and 63.9 years (95% CI: 60–66.9) on the CLTR, a memory task. Conclusion: In conclusion, IPS is the cognitive domain not only most widely affected by MS but it is also the first cognitive deficit to emerge in MS.


2020 ◽  
Vol 12 (3) ◽  
pp. 110-123
Author(s):  
E.I. Donii ◽  
N.B. Shumakova

The work is aimed at identifying specific manifestations of creativity and basic cognitive characteristics in young adolescents with artistic and intellectual giftedness. The relevance of the study is due to lack of study of the issue of cognitive manifestations of different types of giftedness in early adolescence, in which the issue of specialization of education is often resolved. The study involved 54 intellectually gifted adolescents (M = 11.4 years old) and 32 artistically gifted peers (M = 11.2 years old). The study used the following methods: a computerize d battery of test tasks for studying bas ic cognitive characteristics (“number sense”, visua l working memory and information processing speed), "Raven’s Progressive Matrixes”, “Verbally-figura l creativity test”, drawing tests of Urban and "Horizon Line ". The results confirm the hypothesis about the specificity of creativity in younger adolescents with different types of giftedness (intellectual and artistic). Intellectually gifted younger adolescents show higher rates of divergent verbal creativity compared to their artistically gifted peers; and artistically gifted younger adolescents surpass their intellectually gifted peers in terms of picturesque (figurative) creativity and are distinguished by their highquality originality, revealing a high emotional expressiveness and creative approach to the implementation of the plan. No statistically significant intergroup differences in the basic indicators of cognitive development and general intelligence were found, although artistically gifted adolescents better than their intellectually gifted peers compare asymmetrically expressed amounts (“number sense”), but they are inferior in terms of information processing speed.


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