Evidence on technology-driven preoperative exercise interventions: are we there yet?

Preoperative physical exercise protocols prior to cancer surgery increased in popularity over recent years; however, the beneficial effect of such protocols is not well established, with conflicting results reported. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of different modalities or combinations of preoperative exercise interventions and/or prehabilitation multicomponent training in patients with non-small-cell lung cancer (NSCLC) after surgery on the outcomes related to functional capacity, mental wellness and medical care. We searched in OVID Embase, Pubmed, Cochrane Library, CINAHL, Scopus, and Web of Science. Characteristics of studies and program results and outcome data were extracted. Changes between the intervention and control groups, from baseline to follow-up (standardized mean difference (SMD) or relative risk (RR) with 95% confidence interval (CI) for each intervention was pooled using weighted random-effects models). A total of 676 participants from 10 RCTs were included in the final analysis (aerobic training + inspiratory muscle training, n = 5; aerobic training + strength training + inspiratory muscle training, n = 2; aerobic training + strength training, n = 1; multicomponent training, n = 1; aerobic training alone, n = 1). The results showed intervention-induced improvement in walking endurance (SMD = 0.27; 95% CI, 0.11 to 0.44; I2 = 0.0%), peak exercise capacity (SMD = 0.78; 95% CI, 0.35 to 1.21; I2 = 76.7%), dyspnoea (SMD = −0.30; 95% CI, −0.51 to −0.10; I2 = 0.0%), risk of hospitalization (SMD = −0.58; 95% CI, −0.97 to −0.20; I2 = 70.7%), and postoperative pulmonary complications (relative risk (RR) = 0.50; 95% CI, 0.39 to 0.66; I2 = 0.0%). For the functional capacity and medical care parameters, preoperative combined aerobic, resistance, and inspiratory muscle training was shown to be effective if comprising one to four weeks, performing 1–3 sessions per week, with moderate intensity (50% for endurance capacity). Further studies with larger samples and higher methodological quality are needed to clarify the potential benefits of preoperative exercise training for patients with NSCLC.

Download Full-text

Novel and Practical Approaches to Manage Diet-induced Metabolic Disorders: Part-I

Current Pharmaceutical Design ◽

10.2174/138161282639201110165712 ◽

2020 ◽

Vol 26 (39) ◽

pp. 4953-4954

Author(s):

Mallikarjuna Korivi ◽

Betty Revon Liu

Keyword(s):

Metabolic Disorders ◽

Dietary Habits ◽

Healthy Lifestyle ◽

Modern World ◽

Successful Management ◽

Exercise Interventions ◽

Beneficial Effects ◽

Effective Strategies ◽

Dietary Strategies ◽

Global Health Problem

Metabolic syndrome (MetS) which is caused by poor dietary habits and sedentary behavior is a serious global health problem. MetS is a cluster of risk factors, represented by central obesity, hyperglycemia, dyslipidemia, and hypertension. In the 21st century, MetS and associated comorbidities, including obesity, diabetes and cardiovascular diseases, are the major threats to human health. Practical dietary strategies, nutritional bioactive compounds and a healthy lifestyle are claimed to be efficient in the management of one or more components of MetS. Nevertheless successful management of MetS and commodities is still a major concern. Since hyperglycemia, inflammation and redox imbalance are intrinsically involved in the progression of MetS comorbidities, finding effective strategies that precisely target these systems is highly warranted. In this scenario, pharmacological and non-pharmacological approaches with or without dietary patterns, phytochemicals or exercise interventions are the practical strategies to combat MetS and associated diseases. However, designing and prescribing of optimal nutritional patterns and exercise regimens remains a big challenge to achieve the maximum beneficial effects. This thematic issue addressed the concerns and provided practical strategies to overcome the malady of MetS in the modern world.

Download Full-text

Exercise Interventions in Huntington's Disease: An Individual Patient Data Meta‐Analysis

Movement Disorders Clinical Practice ◽

10.1002/mdc3.12809 ◽

2019 ◽

Vol 6 (7) ◽

pp. 567-575

Author(s):

Rebecca Playle ◽

Polyxeni Dimitropoulou ◽

Mark Kelson ◽

Lori Quinn ◽

Monica Busse

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Individual Patient Data ◽

Meta Analysis ◽

Patient Data ◽

Exercise Interventions

Download Full-text

Remote interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review and meta-analysis

BMC Cancer ◽

10.1186/s12885-021-07989-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Saïd Ibeggazene ◽

Rebecca Turner ◽

Derek Rosario ◽

Liam Bourke

Keyword(s):

Systematic Review ◽

Exercise Intervention ◽

Meta Analysis ◽

Exercise Interventions ◽

Exercise Behaviour ◽

Cancer Services ◽

The Social ◽

Intervention Adherence ◽

Randomised Controlled ◽

Exercise Guidelines

Abstract Background The COVID-19 pandemic has forced many cancer services to consider a transition to a remote format of delivery that is largely untested. Accordingly, we sought to perform a systematic review of the effects of remotely delivered interventions to improve exercise behaviour in sedentary adults living with and beyond cancer. Methods Eligible studies were randomised controlled trials comparing a remotely delivered exercise intervention to a usual care comparison in sedentary people over 18 years old with a primary cancer diagnosis. Nine electronic databases were searched from inception to November 2020. Results The review included three trials, totalling 186 participants. Two of the included trials incorporated prescriptions that meet current aerobic exercise recommendations, one of which also meets the guidelines for resistance exercise. No trials reported an intervention adherence of 75% or more for a set prescription that meets current exercise guidelines. Conclusion There is little evidence suggesting that remote exercise interventions promote exercise behaviours or improve physical function in sedentary adults living with and beyond cancer. The development and evaluation of novel remote exercise interventions is needed to establish their usefulness for clinical practice. Given the social response to the COVID-19 pandemic, further research in this area is urgently needed.

Download Full-text

Skeletal Muscle Metabolomic Responses to Endurance and Resistance Training in Rats under Chronic Unpredictable Mild Stress

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041645 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1645

Author(s):

Xiangyu Liu ◽

Xiong Xue ◽

Junsheng Tian ◽

Xuemei Qin ◽

Shi Zhou ◽

...

Keyword(s):

Resistance Exercise ◽

Endurance Exercise ◽

Field Tests ◽

Treadmill Running ◽

Control Group ◽

Mild Stress ◽

Chronic Unpredictable Mild Stress ◽

Sprague Dawley ◽

Exercise Interventions ◽

Sprague Dawley Rats

The objectives of this study were to compare the antidepressant effects between endurance and resistance exercise for optimizing interventions and examine the metabolomic changes in different types of skeletal muscles in response to the exercise, using a rat model of chronic unpredictable mild stress (CUMS)-induced depression. There were 32 male Sprague-Dawley rats randomly divided into a control group (C) and 3 experimental groups: CUMS control (D), endurance exercise (E), and resistance exercise (R). Group E underwent 30 min treadmill running, and group R performed 8 rounds of ladder climbing, 5 sessions per week for 4 weeks. Body weight, sucrose preference, and open field tests were performed pre and post the intervention period for changes in depressant symptoms, and the gastrocnemius and soleus muscles were sampled after the intervention for metabolomic analysis using the 1H-NMR technique. The results showed that both types of exercise effectively improved the depression-like symptoms, and the endurance exercise appeared to have a better effect. The levels of 10 metabolites from the gastrocnemius and 13 metabolites from the soleus of group D were found to be significantly different from that of group C, and both types of exercise had a callback effect on these metabolites, indicating that a number of metabolic pathways were involved in the depression and responded to the exercise interventions.

Download Full-text

Association of Cognitive Function Screening Results with Adherence and Performance in a Pedometer-Based Intervention

American Journal of Nephrology ◽

10.1159/000516130 ◽

2021 ◽

pp. 1-9

Author(s):

Anoop Sheshadri ◽

Piyawan Kittiskulnam ◽

Cynthia Delgado ◽

Rebecca L. Sudore ◽

Jennifer C. Lai ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Physical Performance ◽

Mixed Model ◽

Linear Mixed Model ◽

Controlled Trial ◽

Cognitive Status ◽

Dialysis Patients ◽

Exercise Interventions ◽

And Performance

Introduction: A randomized, controlled trial of a pedometer-based walking intervention with weekly activity goals led to increased walking among dialysis patients. We examined whether impairment per cognitive function screening is associated with adherence and performance in the intervention. Methods: Thirty dialysis patients were randomly assigned to a 3-month pedometer-based intervention with weekly goals. Participants were administered the Telephone Interview of Cognitive Status (TICS), a test of global mental status. We examined the association of levels of impairment on the TICS (≥33: unimpaired, 26–32: ambiguous impairment, 21–25: mild cognitive impairment [MCI]) with adherence, achieving weekly goals, and increasing steps, physical performance (Short Physical Performance Battery, SPPB), and self-reported physical function (PF) through multivariable linear mixed-model and logistic regression analyses adjusted for age, sex, BMI, dialysis modality, baseline steps, baseline SPPB, and stroke status. Results: One-third of participants were unimpaired, and 13% had MCI. Participants with worse results on cognitive function screening missed more calls and completed fewer weekly goals than participants with better results. During the intervention, a worse result on cognitive function screening was associated with smaller increases in steps compared to those without impairment: (ambiguous: −620 [95% CI −174, −1,415], MCI: −1,653 [95% CI −120, −3,187]); less improvement in SPPB (ambiguous: −0.22 points [95% CI −0.08, −0.44], MCI: −0.45 [95% CI −0.13, −0.77]); and less improvement in PF (ambiguous: −4.0 points [95% CI −12.2, 4.1], MCI: −14.0 [95% CI −24.9, −3.1]). During the postintervention period, a worse result on cognitive function screening was associated with smaller increases in SPPB (ambiguous: −0.54 [95% CI −1.27, 0.19], MCI: −0.97 [95% CI −0.37, −1.58]) and PF (ambiguous: −3.3 [95% CI −6.5, −0.04], MCI: −10.5 [95% CI −18.7, −2.3]). Discussion/Conclusion: Participants with worse results on cognitive function screening had worse adherence and derived less benefit from this pedometer-based intervention. Future exercise interventions should be developed incorporating methods to address cognitive impairment, for example, by including caregivers when planning such interventions.

Download Full-text

Influences of exercise interventions on overweight and obesity in children and adolescents

Public Health Nursing ◽

10.1111/phn.12862 ◽

2021 ◽

Author(s):

Junga Lee

Keyword(s):

Children And Adolescents ◽

Overweight And Obesity ◽

Exercise Interventions ◽

Obesity In Children

Download Full-text

A syndemics approach to exercise is medicine

Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine ◽

10.1177/13634593211021481 ◽

2021 ◽

pp. 136345932110214

Author(s):

Caitlin Vitosky Clarke ◽

Brynn C Adamson

Keyword(s):

Mental Illness ◽

Chronic Disease ◽

Social Factors ◽

Social Conditions ◽

Self Concept ◽

Exercise Interventions ◽

Narrow Scope ◽

The Social ◽

Exercise Promotion ◽

The Impact

This paper offers new insights into the promotion of the Exercise is Medicine (EIM) framework for mental illness and chronic disease. Utilising the Syndemics Framework, which posits mental health conditions as corollaries of social conditions, we argue that medicalized exercise promotion paradigms both ignore the social conditions that can contribute to mental illness and can contribute to mental illness via discrimination and worsening self-concept based on disability. We first address the ways in which the current EIM framework may be too narrow in scope in considering the impact of social factors as determinants of health. We then consider how this narrow scope in combination with the emphasis on independence and individual prescriptions may serve to reinforce stigma and shame associated with both chronic disease and mental illness. We draw on examples from two distinct research projects, one on exercise interventions for depression and one on exercise interventions for multiple sclerosis (MS), in order to consider ways to improve the approach to exercise promotion for these and other, related populations.

Download Full-text

A systematic review of rehabilitation in chronic heart failure: evaluating the reporting of exercise interventions

ESC Heart Failure ◽

10.1002/ehf2.13498 ◽

2021 ◽

Author(s):

Amy E. Harwood ◽

Sophie Russell ◽

Nduka C. Okwose ◽

Scott McGuire ◽

Djordje G. Jakovljevic ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Chronic Heart Failure ◽

Exercise Interventions

Download Full-text