Assessment of the ameliorative role of selenium nanoparticles on the oxidative stress of acetaminophen in some tissues of male albino rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

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Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104622 ◽

2020 ◽

Vol 113 ◽

pp. 104622 ◽

Cited By ~ 3

Author(s):

Shahenda Mahgoub ◽

Anas O. Sallam ◽

Hazem K.A. Sarhan ◽

Amal A.A. Ammar ◽

Sameh H. Soror

Keyword(s):

Oxidative Stress ◽

Gamma Radiation ◽

Albino Rats ◽

Wistar Albino Rats

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The ameliorative role of silymarin on trichloroethylene-induced oxidative stress in male albino rats

Oxidants and Antioxidants in Medical Science ◽

10.5455/oams.301012.or.023 ◽

2012 ◽

Vol 1 (3) ◽

pp. 193 ◽

Cited By ~ 1

Author(s):

Ola Gharib ◽

Usama AbdEllatif ◽

Nadia Abdellah ◽

Marwa Mohammad

Keyword(s):

Oxidative Stress ◽

Albino Rats

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Radioprotective Role of Some Bacteria Belonging to Actinomycetales against Gamma Irradiation-Induced Oxidative Stress in Male Albino Rats

The Egyptian Journal of Hospital Medicine ◽

10.12816/0029028 ◽

2016 ◽

Vol 64 ◽

pp. 364-372 ◽

Cited By ~ 2

Author(s):

Seham Abdel-Shafi ◽

Tamer M. M. Saad ◽

M. E. F. Abdel-Haliem

Keyword(s):

Oxidative Stress ◽

Gamma Irradiation ◽

Albino Rats

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Modulation ofN-methyl-d-aspartate receptors in isolated rat heart

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2017-0056 ◽

2017 ◽

Vol 95 (11) ◽

pp. 1327-1334 ◽

Cited By ~ 5

Author(s):

Ivan Srejovic ◽

Vladimir Zivkovic ◽

Tamara Nikolic ◽

Nevena Jeremic ◽

Isidora Stojic ◽

...

Keyword(s):

Oxidative Stress ◽

Rat Heart ◽

Isolated Rat Heart ◽

Albino Rats ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers ◽

Combined Application ◽

Wistar Albino Rats ◽

Isolated Rat

Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dtmax, dp/dtmin, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO2−, O2−, and H2O2. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.

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Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine

Journal of Toxicology ◽

10.1155/2018/8023840 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Arwa A. El-Sheikh ◽

Shimaa Hamed Ameen ◽

Samaa Salah AbdEl-Fatah

Keyword(s):

Oxidative Stress ◽

Iron Overload ◽

Adult Male ◽

Caspase 3 ◽

Iron Chelation ◽

Male Rats ◽

Albino Rats ◽

Tissue Iron ◽

Small Intestinal

Objective. The aim of our study is to compare the role of the new natural alternative (Quercetin) with the current iron-chelation therapy (Deferoxamine (DFO)) in the effect of iron overload on small intestinal tissues and to investigate the possible underlying molecular mechanisms of such toxicity. Methods. Forty-two adult male albino rats were divided into six groups: control groups, DFO, Quercetin, iron overload, iron overload+DFO, and iron overload+Quercetin groups. Animals received daily intraperitoneal injection of Deferoxamine (125 mg /kg), Quercetin (10 mg/kg), and ferric dextran (200 mg/kg) for 2 weeks. Results. Iron overloaded group showed significant increase in serum iron, total iron binding capacity (TIBC), transferrin saturation percentage (TS %) hepcidin (HEPC), serum ferritin, nontransferrin bound iron (NTBI), and small intestinal tissues iron levels. Iron overload significantly increased the serum oxidative stress indicator (MDA) and reduced serum total antioxidant capacity (TAC). On the other hand, iron overload increased IL6 and reduced IL10 in small intestinal tissues reflecting inflammatory condition and increased caspase 3 reactivity indicating apoptosis and increased iNOs expressing cell indicting oxidative stress especially in ileum. In addition, it induced small intestinal tissues pathological alterations. The treatment with Quercetin showed nonsignificant differences as compared to treatment with DFO that chelated the serum and tissue iron and improved the oxidative stress and reduced tissue IL6 and increased IL10 and decreased caspase 3 and iNOs expressing cells in small intestinal tissues. Moreover, it ameliorated the iron overload induced pathological alterations. Conclusion. Our study showed the potential role of Quercetin as iron chelator like DFO in case of iron overload induced small intestinal toxicity in adult rats because of its serum and tissue iron chelation, improvement of serum, and small intestinal oxidative stress, ameliorating iron induced intestinal inflammation, apoptosis, and histopathological alterations.

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AMELIORATIVE ROLE OF SILYMARIN AGAINST ASPARTAME–INDUCED BIOCHEMICAL CHANGES, OXIDATIVE STRESS, INFLAMMATORY EFFECT AND GENOTOXICITY IN MALE ALBINO RATS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i1.36831 ◽

2020 ◽

pp. 41-55

Author(s):

SABHA E. ELBALLAT ◽

AL-SHIMAA M. ABAS

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

World Health ◽

Control Group ◽

Albino Rats ◽

Antioxidative Status ◽

Tnf Α ◽

Recovery Group ◽

Different Tissues

Objective: Aspartame (ASP) is one of the most common artificial sweeteners. It has been recorded to be safe by World Health Organization. However, numerous publications have concluded that ASP is a genotoxic and carcinogenic sweetener. Methods: The current study aims to examine the effect of ASP consumption (250 mg/kg body weight/day for 90 d) on some biochemical parameters, oxidative/antioxidative status in different tissues, Tumor Necrosis Factor-α (TNF-α), chromosomal aberration (CA) frequency and mitotic index (MI) percentage in addition to the possible ameliorative role of silymarin (50 mg/kg body weight/day for 90 d) against ASP-induced toxicity in male albino rats. Results: The present results have confirmed that ASP is able to induce significant increase in the blood glucose level, liver, kidney and lipid function tests, Malondialdehyde (MDA) level, serum TNF-α level, frequency of CA and MI%. Meanwhile, Glutathione reduced level (GSH), Glutathione–S-transferase (GST) and catalase activity (CAT) were decreased by ASPadministration. Recovery group showed slight enhancement in all parameters but remained significant as compared to the control group. Co-administration of ASP with silymarin showed greater improvement than the recovery group. Conclusion: Silymarin have an ameliorative role against biochemical oxidative stress, inflammatory changes in blood and different tissues, chromosomal aberrations and MI% induced by ASP administration.

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Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

Advances in Toxicology ◽

10.1155/2014/641813 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Dinesh Bheeman ◽

Sinjula Cheerothsahajan ◽

Sathish Sugumaran ◽

Sankaran Mathan ◽

Ramesh Mathan ◽

...

Keyword(s):

Oxidative Stress ◽

Titanium Oxide ◽

Total Protein ◽

Total Bilirubin ◽

Protective Role ◽

Albino Rats ◽

Oxide Nanoparticles ◽

Histopathological Changes ◽

Titanium Oxide Nanoparticles

Protective role of 2-imino-4-methyl-1, 2-dihydropyrimido [5, 4C] quinoline-5(6H)-one (IMDHPQ) in indium titanium oxide nanoparticles (InTiO NPs) induced hepatotoxicity was analyzed. InTiO NPs were synthesized and given orally to albino rats to assess their hepatotoxicity. NPs mediated oxidative stress and liver tissue pathology were analyzed. Altered antioxidants (GSH, GPx, and catalase) and, biochemical (SGOT, SGPT, ALP, total protein, and total bilirubin) and histopathological changes were observed due to the oxidative stress caused by InTiO NPs. Varying effects of IMDHPQ on each parameter were observed in the present study. The altered parameters of InTiO NPs exposed rats might be due to the oxidative stress caused by NPs and hepatoprotective or ameliorative efficacy of quinoline compound IMDHPQ on signaling and molecular mechanism needs further study.

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