Titanium cranioplasty construction for large craniofacial defects: the Leeds method

2008 ◽  
Vol 46 (7) ◽  
pp. e11
Author(s):  
Lachlan M. Carter ◽  
P. Bartlett ◽  
J.L. Russell
Keyword(s):  
Titanium Cranioplasty ◽  
Craniofacial Defects

scholarly journals Association between metal hypersensitivity and implant failure in patients who underwent titanium cranioplasty

2019 ◽  
Vol 131 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Yirui Sun ◽  
Yue Hu ◽  
Qiang Yuan ◽  
Jian Yu ◽  
Xing Wu ◽  
...  
Keyword(s):  
Titanium Implant ◽  
Implant Failure ◽  
Titanium Plate ◽  
Metal Hypersensitivity ◽  
Implant Exposure ◽  
Major Complications ◽  
Alternative Materials ◽  
Titanium Cranioplasty ◽  
Craniofacial Defects

OBJECTIVEDigitally designed titanium plates are commonly used for the reconstruction of craniofacial defects, although implant exposure (referred to as failure) is one of the major complications. Metal hypersensitivities have been suggested as possible causes of implant failure of orthopedic, intravascular, gynecological, and dental devices, yet there has been no consensus on the requirement for allergy screening before cranioplasty.METHODSIn this study, the authors prospectively investigated the prevalence of metal hypersensitivity in patients for whom cranioplasty is planned and assess its relationship with titanium implant failure (exposure).RESULTSBased on records from 207 included patients, 39.61% of patients showed hypersensitivity to at least one kind of metal. Approximately one-quarter (25.12%) of patients had multiple metal allergies. Co, Cd, and Zn were the 3 most frequently identified metal hypersensitivities. No allergy to titanium was detected in this study. The overall incidence of cranioplasty implant failure was 5.31% (11 of 207). Patients showing hypersensitivities to more than 3 kinds of metal had higher risks of titanium plate exposure.CONCLUSIONSBased on their findings, the authors suggest that routine allergy screening be performed before titanium plate cranioplasty. For patients with hypersensitivities to more than 3 metals, alternative materials, such as polyetheretherketone, should be considered for cranioplasty.

scholarly journals Maternal iron deficiency perturbs embryonic cardiovascular development in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jacinta I. Kalisch-Smith ◽  
Nikita Ved ◽  
Dorota Szumska ◽  
Jacob Munro ◽  
Michael Troup ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Environment Interaction ◽  
Cardiovascular Development ◽  
Retinoic Acid Signalling ◽  
Gene Environment Interaction ◽  
Iron Administration ◽  
Gene Environment ◽  
Cardiovascular Defects ◽  
Craniofacial Defects ◽  
Maternal Iron

AbstractCongenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene–environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women.

scholarly journals Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

2020 ◽  
Vol 21 (24) ◽  
pp. 9759
Author(s):  
Agnieszka Arthur ◽  
Stan Gronthos
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Genetic Manipulation ◽  
Bioactive Molecules ◽  
Long Bone ◽  
Differentiation Potential ◽  
Skeletal Tissue ◽  
Recent Developments ◽  
Multipotent Differentiation ◽  
Craniofacial Defects

There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.

Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 977-983 ◽  
Author(s):  
A. Zimmer ◽  
A. Zimmer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Induction Pattern ◽  
The Central Nervous System ◽  
Beta 2 ◽  
Transgenic Embryos ◽  
Craniofacial Defects ◽  
Pair Rule

The hormone retinoic acid (RA) has been implicated in the organization of the anteroposterior (AP) body axis. In this paper, we describe the effects of RA on the activity of the RA-inducible retinoic acid receptor-beta 2 (RAR beta 2) promoter. When transgenic embryos carrying a RAR beta 2-lacZ reporter gene were exposed to a single dose of RA between gestational days 8.5 to 10.5, lacZ expression was induced in the anterior central nervous system (CNS). Strikingly, the transgene was expressed in a segmented pattern reminiscent of that of Drosophila ‘pair-rule’ genes. RA treatment of midgastrulation embryos at day 7.5 disturbed the segmentation and produced severe craniofacial defects. We discuss the possibility that the entire anterior CNS is segmented and that this segmentation is reflected by the RAR beta 2-lacZ induction pattern.

STUDY OF INCIDENCE OF THE CORONAL APPROACH IN CRANIOFACIAL TRAUMA AND ADVANTAGEOUS OF TITANIUM MESH IN RECONSTRUCTION OF CRANIOFACIAL DEFECTS.

2021 ◽  
pp. 53-54
Author(s):  
Mastan Shaik
Keyword(s):  
Maxillofacial Surgery ◽  
Frontal Bone ◽  
Male Participant ◽  
Female Participant ◽  
Oral And Maxillofacial Surgery ◽  
Industrial Accidents ◽  
Nasal Bones ◽  
Aesthetic Results ◽  
One Year ◽  
Craniofacial Defects

INTRODUCTION: The coronal approach gives a broad exposure to the frontal bone, the calvaria, the nasal bones, the orbits, the subcondylar region, the zygoma and the zygomatic arch and gives ideal aesthetic results with less complication. The common craniofacial fractures are Nasal bones (45%), cranial bones (24%), Mandible (13%), Zygoma (13%), Orbital blowout (3%), Maxilla (2%). Common causes of fractures are Road trafc accident, Assault, Industrial accidents, Recreational accidents, Frontal bone fracture. METHOD: The study was carried out for a period of one year from March 2020 to March 2021. The study conducted in St Joseph dental college ELURU in the department of Oral and Maxillofacial Surgery. The age limit for this study was below 30 years. The number of subjects involved in this study was 5. Number of females was 3 and males were 2 in this study. RESULT: Number of female participants in this study was 3 and number of male participants was 2.Number of male participants with coronal incision were 1 and number of participants with pretrichial incision were 2.Out of 2 one for male participant and one for female participant. CONCLUSION: The coronal ap has recently become a preferred approach for access to the craniofacial skeleton and orbit. This method of exposure has become particularly useful with increased indications for rigid internal xation and primary bone grafting in the management of complex facial fractures.

scholarly journals Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis

2006 ◽  
Vol 119 (17) ◽  
pp. 3593-3601 ◽  
Author(s):  
Inderpreet Sur ◽  
Björn Rozell ◽  
Viljar Jaks ◽  
Åsa Bergström ◽  
Rune Toftgård
Keyword(s):  
Basal Layer ◽  
Craniofacial Defects

scholarly journals Knockdown of Mns1 Increases Susceptibility to Craniofacial Defects Following Gastrulation-Stage Alcohol Exposure in Mice

2018 ◽  
Vol 42 (11) ◽  
pp. 2136-2143 ◽  
Author(s):  
Karen E. Boschen ◽  
Henry Gong ◽  
Laura B. Murdaugh ◽  
Scott E. Parnell
Keyword(s):  
Alcohol Exposure ◽  
Craniofacial Defects

scholarly journals Mutations in P63 and IRF-6 Present with Overlapping Craniofacial Defects: A study from Lebanon

2019 ◽  
pp. 1-3
Author(s):  
Mazen Kurban ◽  
Edgar Jabbour ◽  
Lamiaa Hamie ◽  
Mazen Kurban ◽  
Pamela Kassabian
Keyword(s):  
Transcription Factors ◽  
Cleft Lip ◽  
Interferon Regulatory Factor ◽  
Craniofacial Development ◽  
Regulatory Factor ◽  
Van Der Woude Syndrome ◽  
Interferon Regulatory Factor 6 ◽  
Cleft Lip Palate ◽  
Exon 9 ◽  
Craniofacial Defects

Interferon Regulatory Factor 6 (IRF-6) and p63 are two vital transcription factors implicated in normal craniofacial development. In this report, we present a family with Van Der Woude Syndrome (VWS) with a mutation in exon 9 of IRF-6 gene and a phenotypically overlapping case of Rapp-Hodgkin Syndrome (RHS) resulting from a mutation in the p63 gene. Members from both families presented with congenital lip pits and cleft lip/palate. The RHS case had additional ectodermal features that underscore the upstream nature of p63 in the complex p63-IRF-6 interactive pathway.

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