scholarly journals Investigating the rigour of research findings in experimental studies assessing the effects of breaking up prolonged sitting – extended scoping review

2020 ◽  
Author(s):  
Coralie English ◽  
Ishanka Weerasekara ◽  
Anjelica Carlos ◽  
Sebastien Chastin ◽  
Gary Crowfoot ◽  
...  
Keyword(s):  
Scoping Review ◽  
Experimental Studies ◽  
Prolonged Sitting ◽  
Research Findings

Diabetes, Diabetic Complications, and Phosphate Toxicity: A Scoping Review

2020 ◽  
Vol 16 (7) ◽  
pp. 674-689 ◽  
Author(s):  
Ronald B. Brown
Keyword(s):  
Scoping Review ◽  
Diabetic Complications ◽  
Inorganic Phosphate ◽  
Dietary Intervention ◽  
Neuronal Degeneration ◽  
Ectopic Calcification ◽  
Treatment And Prevention ◽  
Research Findings ◽  
Serum Inorganic Phosphate ◽  
Prevention Of Diabetes

This article presents a scoping review and synthesis of research findings investigating the toxic cellular accumulation of dysregulated inorganic phosphate—phosphate toxicity—as a pathophysiological determinant of diabetes and diabetic complications. Phosphorus, an essential micronutrient, is closely linked to the cellular metabolism of glucose for energy production, and serum inorganic phosphate is often transported into cells along with glucose during insulin therapy. Mitochondrial dysfunction and apoptosis, endoplasmic reticulum stress, neuronal degeneration, and pancreatic cancer are associated with dysregulated levels of phosphate in diabetes. Ectopic calcification involving deposition of calcium-phosphate crystals is prevalent throughout diabetic complications, including vascular calcification, nephropathy, retinopathy, and bone disorders. A low-glycemic, low-phosphate dietary intervention is proposed for further investigations in the treatment and prevention of diabetes and related diabetic pathologies.

The Scoping Review of Smart Healthcare Applications in Medical Health (Preprint)

2020 ◽  
Author(s):  
Cheng Hang Wu ◽  
Ching Ju Chiu ◽  
Yen Ju Liou ◽  
Chun Ying Lee ◽  
Susan C. Hu
Keyword(s):  
Systematic Reviews ◽  
Mobile Health ◽  
Scoping Review ◽  
Search Strategy ◽  
Rapid Development ◽  
Related Research ◽  
Geographic Access ◽  
Smart Healthcare ◽  
Research Findings ◽  
Healthcare Interventions

BACKGROUND There is still no consensus on research terms for smart healthcare worldwide. The study conducted by Lewis 10 years ago showed extending geographic access was the major health purpose of health-related information communication technology (ICT), but today's situation may be different because of the rapid development of smart healthcare. Objective: The main aim of this study is to classify recent smart healthcare interventions. Therefore, this scoping review was conducted as a feasible tool for exploring this domain and summarizing related research findings. OBJECTIVE The main aim of this study is to classify recent smart healthcare interventions. Therefore, this scoping review was conducted as a feasible tool for exploring this domain and summarizing related research findings. METHODS The scoping review relies on the analysis of previous reviews of smart healthcare interventions assessed for their effectiveness in the framework of a systematic review and/or meta-analysis. The search strategy was based on the identification of smart healthcare interventions reported as the proposed keywords. In the analysis, the reviews published from January 2015 to December 2019 were included. RESULTS The number of publications for smart healthcare's systematic reviews has continued to grow in the past five years. The search strategy yielded 210 systematic reviews and/or meta-analyses addressed to target groups of interest. 68.5% of these publications used mobile health as a keyword. According to the classification by Lewis, 37.62% of the literature was applied to extend geographic access. According to the classification by the Joint Commission of Taiwan (JCT), 48.84% of smart healthcare was applied in clinical areas, and 60% of it was applied in outpatient medical services. CONCLUSIONS Smart healthcare interventions are being widely used in clinical settings and for disease management. The research of mobile health has received the most attention among smart healthcare interventions. The main purpose of mobile health was used to extend geographic access to increase medical accessibility in clinical areas. CLINICALTRIAL none

scholarly journals ‘The awesome power of yeast’ in Alzheimer’s disease research

2021 ◽  
Vol 42 (3) ◽  
pp. 130
Author(s):  
Sudip Dhakal
Keyword(s):  
Simple Model ◽  
Animal Models ◽  
Human Brain ◽  
Human Cell ◽  
Cell Biology ◽  
Experimental Studies ◽  
Disease Models ◽  
Disease Research ◽  
Research Findings ◽  
Technological Platforms

The difficulties in performing experimental studies related to diseases of the human brain have fostered a range of disease models from highly expensive and complex animal models to simple, robust, unicellular yeast models. Yeast models have been used in numerous studies to understand Alzheimer’s disease (AD) pathogenesis and to search for drugs targeting AD. Thanks to the conservation of fundamental eukaryotic processes including ageing and the availability of appropriate technological platforms, budding yeast are a simple model eukaryote to assist with understanding human cell biology, offering a platform to study human diseases. This article aims to provide insights from yeast models on the contributions of amyloid beta, a causative agent in AD, and recent research findings on AD chemoprevention.

Abstract PO-120: Need for more sociodemographic data in qualitative childhood cancer research: Findings from a scoping review

2022 ◽  
Author(s):  
Sarah Burack ◽  
Eric M. Wiedenman ◽  
Melanie Ward ◽  
Lindsay Kaufman ◽  
Thembekile Shato ◽  
...  
Keyword(s):  
Cancer Research ◽  
Childhood Cancer ◽  
Scoping Review ◽  
Sociodemographic Data ◽  
Research Findings

Problems and Barriers related to the Use of Digital Health Applications: A Scoping Review Protocol (Preprint)

2021 ◽  
Author(s):  
Godwin Denk Giebel ◽  
Christian Speckemeier ◽  
Carina Abels ◽  
Kirstin Börchers ◽  
Jürgen Wasem ◽  
...  
Keyword(s):  
Scoping Review ◽  
Digital Health ◽  
Health Care Systems ◽  
Grey Literature ◽  
Screening Process ◽  
Care Systems ◽  
Research Findings ◽  
Review Protocol ◽  
Definition Of ◽  
Health Applications

BACKGROUND Usage of digital health applications (DHA) is increasing internationally. More and more regulatory bodies develop regulations and guidelines to enable an evidence-based and safe use. In Germany, DHA fulfilling predefined criteria (Digitale Gesundheitsanwendungen (="DiGA")) can be prescribed and are reimbursable by the German statutory health insurance scheme. Due to the increasing distribution of DHA problems and barriers should receive special attention. OBJECTIVE This study aims to identify relevant problems and barriers related to the use of DHA fulfilling the criteria of DiGA. The research done in this area will be mapped and research findings will be summarized. METHODS Conduct of the scoping review will follow published methodological frameworks and PRISMA-Scr criteria. Electronic databases (MEDLINE, EMBASE, and PsycINFO), reference lists of relevant articles and grey literature sources will be searched. Two reviewers will assess eligibility of articles by a two-stage (title/abstract and full-text) screening process. Only problems and barriers related to DHA fulfilling the criteria of DiGA are included for this research. RESULTS This scoping review serves to give an overview about the available evidence and to identify research gaps with regards to problems and barriers related to DiGA. Results are planned to be submitted to an indexed, peer-reviewed journal in the fourth quarter of 2021. CONCLUSIONS This is the first review identifying problems and barriers specifically to the use of the German definition of DiGA. Nevertheless, our findings can presumably be applied to other contexts and health care systems as well.

scholarly journals Smart but Evil? Student-Teachers’ Perception of Educational Researchers’ Epistemic Trustworthiness

AERA Open ◽  
2019 ◽  
Vol 5 (3) ◽  
pp. 233285841986815
Author(s):  
Samuel Merk ◽  
Tom Rosman
Keyword(s):  
Preservice Teachers ◽  
Student Teachers ◽  
Exploratory Study ◽  
Classroom Practice ◽  
Scientific Evidence ◽  
Experimental Studies ◽  
Epistemic Beliefs ◽  
Research Results ◽  
Research Findings ◽  
Integrate Research

In-service and preservice teachers are increasingly required to integrate research results into their classroom practice. However, due to their limited methodological background knowledge, they often cannot evaluate scientific evidence firsthand and instead must trust the sources on which they rely. In two experimental studies, we investigated the amount of this so-called epistemic trustworthiness (dimensions expertise, integrity, and benevolence) that student-teachers ascribe to the authors of texts who present classical research findings (e.g., learning with worked-out examples) that allegedly were written by a practitioner, an expert, or a scientist. Results from the first exploratory study suggest that student-teachers view scientists as “smart but evil,” since they rate them as having substantially more expertise than practitioners, while also being less benevolent and lacking in integrity. Moreover, results from the exploratory study suggest that evaluativistic epistemic beliefs (beliefs about the nature of knowledge) predict epistemic trustworthiness. A preregistered conceptual replication study (Study 2) provided more evidence for the “smart but evil” stereotype. Further directions of research as well as implications for practice are discussed.

scholarly journals What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0217981
Author(s):  
Paul Mackie ◽  
Ishanka Weerasekara ◽  
Gary Crowfoot ◽  
Heidi Janssen ◽  
Elizabeth Holliday ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Scoping Review ◽  
Stroke Risk ◽  
Recurrent Stroke ◽  
Stroke Risk Factors ◽  
Prolonged Sitting

Psychosocial Depression Interventions for Dialysis Patients, With Attention to Latinos: A Scoping Review

2019 ◽  
Vol 29 (8) ◽  
pp. 910-923 ◽  
Author(s):  
John E. Sullivan ◽  
Namkee G. Choi ◽  
Christian E. Vazquez ◽  
Margaret A. Neaves
Keyword(s):  
Scoping Review ◽  
Expressive Writing ◽  
Behavioral Therapy ◽  
Grey Literature ◽  
Behavioral Problem ◽  
Experimental Studies ◽  
The United States ◽  
Cognitive Behavioral ◽  
Dialysis Patients ◽  
Quasi Experimental

Purpose: Depression is a common and debilitating condition that often goes undetected and untreated among people with end-stage renal disease (ESRD). We conducted a scoping review to identify psychosocial depression interventions for adult dialysis patients and gaps in depression care, with particular attention to Latinos, a group disproportionately affected by ESRD in the United States. Methods: We searched electronic databases and grey literature sources for studies in English and Spanish. Results: We found 36 studies including cognitive behavioral, problem-solving, hope, psychoeducation, expressive writing, and physical activity interventions. Twelve studies (33%) were U.S.-based, while the rest were conducted elsewhere. U.S.-based studies involved mostly individual-format cognitive behavioral therapy (CBT) interventions carried out during dialysis. CBTs showed the most promising effect on depression in both randomized clinical and quasi-experimental studies. Among 22 randomized trials reviewed, 1 reported participants with Latino/Hispanic ethnicity. Conclusions: More intervention research is needed for depression treatment with ESRD patients, especially Latinos.

A scoping review of the evidence for efficacy of acupuncture in companion animals

2017 ◽  
Vol 18 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Wesley J. Rose ◽  
Jan M. Sargeant ◽  
W. J. Brad Hanna ◽  
David Kelton ◽  
Dianna M. Wolfe ◽  
...  
Keyword(s):  
Scoping Review ◽  
Case Reports ◽  
Companion Animals ◽  
Experimental Studies ◽  
Case Series ◽  
Complex Nature ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Meta Analyses ◽  
Experimental Trials

AbstractAcupuncture has become increasingly popular in veterinary medicine. Within the scientific literature there is debate regarding its efficacy. Due to the complex nature of acupuncture, a scoping review was undertaken to identify and categorize the evidence related to acupuncture in companion animals (dogs, cats, and horses). Our search identified 843 relevant citations. Narrative reviews represented the largest proportion of studies (43%). We identified 179 experimental studies and 175 case reports/case series that examined the efficacy of acupuncture. Dogs were the most common subjects in the experimental trials. The most common indication for use was musculoskeletal conditions, and the most commonly evaluated outcome categories among experimental trials were pain and cardiovascular parameters. The limited number of controlled trials and the breadth of indications for use, outcome categories, and types of acupuncture evaluated present challenges for future systematic reviews or meta-analyses. There is a need for high-quality randomized controlled trials addressing the most common clinical uses of acupuncture, and using consistent and clinically relevant outcomes, to inform conclusions regarding the efficacy of acupuncture in companion animals.

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