The menopause correlate with changes in physiological, psychological and biochemical characterized, and also body mass index. The study was analyzed the level of glutamic pyruvic transaminase activity (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and estimation of body mass index (BMI) in postmenopausal women (n=20) (50-70)years old and premenopausal women (n=20) (30-40) years old. In postmenopausal women the activity of glutamic pyruvic transaminase (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and body mass index (BMI) was elevated significantly as compared to premenopausal women (p<0.05) , (P<0.004) , (P<0.002) and (p<0.016) respectably . This study showed with age advances liver become injury and gets abnormal liver functions.