scholarly journals Effect of postmenopausal on some liver biochemical markers in Kirkuk women’s

2021 ◽  
Vol 26 (1) ◽  
pp. 17-23
Author(s):  
Noori Mohammed
Keyword(s):  
Body Mass Index ◽  
Alkaline Phosphatase ◽  
Postmenopausal Women ◽  
Phosphatase Activity ◽  
Body Mass ◽  
Alkaline Phosphatase Activity ◽  
Premenopausal Women ◽  
Glutamic Pyruvic Transaminase ◽  
Transaminase Activity ◽  
Glutamic Oxaloacetic Transaminase

   The menopause correlate with changes in physiological, psychological and biochemical characterized, and also body mass index. The study was analyzed the level of glutamic pyruvic transaminase activity (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and estimation of body mass index (BMI) in postmenopausal women (n=20) (50-70)years old and premenopausal women (n=20) (30-40) years old. In postmenopausal women the activity of glutamic pyruvic transaminase (GPT) , glutamic oxaloacetic transaminase activity (GOT) , alkaline phosphatase activity (ALP) and body mass index (BMI)  was elevated significantly as compared to premenopausal women (p<0.05) , (P<0.004) , (P<0.002) and (p<0.016) respectably . This study showed with age advances liver become injury and gets abnormal liver functions.

scholarly journals Effect sleep deprivation on some liver enzymes for adults males

2021 ◽  
Vol 26 (4) ◽  
pp. 485-490
Author(s):  
Noori mohammed
Keyword(s):  
Body Mass Index ◽  
Sleep Deprivation ◽  
Body Mass ◽  
Liver Enzymes ◽  
Serum Bilirubin ◽  
Total Serum ◽  
Glutamic Pyruvic Transaminase ◽  
Probability Level ◽  
Glutamic Oxaloacetic Transaminase ◽  
Healthy Persons

        The current study was designed for two groups, each group contain (20) nonsmokers healthy persons males, first group was get (more than 7 hours sleep / day) , while the second group did not get enough sleep hours (less than 7 hours sleep / day). The results showed a significant  increase in the level of body mass index (BMI) , the activity of glutamic pyruvic transaminase enzyme (GPT), glutamic oxaloacetic transaminase enzyme (GOT) and concentration of total serum bilirubin (TSB) at probability level (P≤0.049 , P≤0.047 , P≤0.032 , P≤0.035) Respectively in Persons with second group compared to Persons with first group, as well as the study showed a positive correlation between the studied parameters , with increase of all parameters  in the second group with each other as a result of the same reason.

scholarly journals Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers

2019 ◽  
Vol 189 (7) ◽  
pp. 660-670 ◽  
Author(s):  
Tianyi Huang ◽  
Amy L Shafrir ◽  
A Heather Eliassen ◽  
Kathryn M Rexrode ◽  
Shelley S Tworoger
Keyword(s):  
Body Mass Index ◽  
Confidence Interval ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Premenopausal Women ◽  
Inflammatory Biomarkers ◽  
Health Study ◽  
Age At Menarche ◽  
Age At Menopause ◽  
Reproductive Events

Abstract Reproductive events, such as ovulation, trigger an inflammatory cascade. Few studies have examined their long-term influence on inflammatory profiles. We included 3,393 premenopausal and 3,915 postmenopausal women with intact ovaries/uterus from the Nurses’ Health studies (Nurses’ Health Study (1989–1990) and Nurses’ Health Study II (1996–1999)) in an analysis of the association between lifetime ovulatory years (LOY) and levels of inflammatory biomarkers. We estimated LOY as age at menopause (age at blood collection for premenopausal women) minus age at menarche, subtracting years of oral contraceptive (OC) use and 1 year per pregnancy. After adjustment for other inflammation-related factors (e.g., body mass index, exercise, diet), every 5-year increase in LOY was associated with lower C-reactive protein (CRP) levels in both premenopausal (difference = −11.5%, 95% confidence interval: −15.0, −8.0; P &lt; 0.0001) and postmenopausal (difference = −7.2%, 95% confidence interval: −10.0, −4.3; P &lt; 0.0001) women. Older age at menopause (P = 0.007), earlier menarche (P = 0.007), and shorter duration of OC use (P = 0.002) were associated with lower CRP levels in postmenopausal women, whereas duration of OC use was positively associated with CRP levels in premenopausal women (P &lt; 0.0001). LOY was modestly inversely associated with interleukin 6 in postmenopausal women (P = 0.03). Notably, the associations of CRP with LOY were similar in magnitude to associations with exercise and a healthy diet, though weaker than the association with body mass index. Although many reproductive events induce acute inflammation, increased LOY was associated with lower chronic systemic inflammation even after menopause.

Rise in Plasma Alkaline Phosphatase at the Menopause

1980 ◽  
Vol 58 (4) ◽  
pp. 341-342 ◽  
Author(s):  
R. G. Crilly ◽  
M. M. Jones ◽  
A. Horsman ◽  
B. E. C. Nordin
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Plasma Alkaline Phosphatase ◽  
Hydroxyproline Excretion

1. Plasma alkaline phosphatase activity and urine hydroxyproline excretion were measured in age-matched premenopausal and postmenopausal women. 2. Both measurements were found to be significantly higher in postmenopausal women. 3. It is proposed that the rise in the plasma alkaline phosphatase, like that in the hydroxyproline excretion, may reflect the onset of bone loss that occurs after the menopause.

scholarly journals Association of obesity with serum estrogen level in postmenopausal women

2016 ◽  
Vol 45 (2) ◽  
pp. 79-84
Author(s):  
Nahid Yeasmin ◽  
Mir Jakib Hossain ◽  
Iqbal Hossain ◽  
Qazi Shamima Akther
Keyword(s):  
Body Mass Index ◽  
Cardiovascular Diseases ◽  
Waist Circumference ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Abdominal Obesity ◽  
Premenopausal Women ◽  
Control Group ◽  
Cross Sectional ◽  
Estrogen Level

Incidence of obesity among postmenopausal women is increasing throughout the world, leading to life threatening medical problem like cardiovascular diseases, type 2 diabetes mellitus. Estrogen deficiency that develops during menopause is likely the etiological factors for development of abdominal obesity. Increased incidence of cardiovascular diseases in postmenopausal women may be due to abdominal obesity caused by lower level of estrogen hormone. The study was carried out to observe the association of obesity with serum estrogen level in postmenopausal women. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of 90 female subjects were selected from different areas of Dhaka city. Among them, 60 postmenopausal women with age ranging from 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women with age ranging from 20 to 30 years were included as control group for comparison. Waist circumference was measured and body mass index (BMI) was calculated in both groups. Serum estrogen level was estimated in order to assess the hormonal level of postmenopausal women. The value of waist circumference was higher in postmenopausal women than those of premenopausal women and result was statistically non significant. Body mass index value was significantly (p<0.001) higher in postmenopausal women in comparison to those of premenopausal women. In postmenopausal women serum estrogen level was lower than premenopausal women and serum estrogen level showed negative correlation with waist circumference and body mass index values. All these correlations were statistically non significant. Present study revealed that there is association of obesity with serum estrogen level in postmenopausal women.Bangladesh Med J. 2016 May; 45 (2): 79-84

scholarly journals Study of the Toxic effect of new Cadmium ( II) complex [ CdL2]. 1/2H2O on GPT and ALP activity in some organs of female mice comparable with anitumor drug Cyclophosphamide (CP)

2015 ◽  
Vol 12 (1) ◽  
pp. 140-147
Author(s):  
Baghdad Science Journal
Keyword(s):  
Alkaline Phosphatase ◽  
Drinking Water ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Transaminase Activity ◽  
Glutamate Pyruvate Transaminase ◽  
Liver And Kidney ◽  
Contaminated Drinking Water ◽  
Glutamate Pyruvate ◽  
Different Doses

Cadmium has been known to be harmful to human healthy , manily Via contaminated drinking water , food supplies , tobacco and industrial pollutant . The aim of this study was to determine the toxicity of new Cadmium (II) complex ( Bis[ 5- ( P- nitrophenyl ) – ? 4 – Phenyl- 1,2,4- triazole -3- dithiocarbamatohydrazide] cadmium (II) Hydra ( 0.5) and compare it with anticancer drug cyclophosphamide ( CP) in female albino mice . This complex causes to several alterations in Enzymatic activity of Glutamate Pyruvate Transaminase (GPT) and Alkaline Phosphatase (ALP ) in three organs after the treatment of mice with different doses of a new cadmium (II) complex ( 0.09 / 0.25ml , 0.18/ 0.5ml and 0.25mg /0.7 ml /30 gm of mouse ) for three days by the decreased of Glutamate Pyruvate Transaminase activity in lung , Liver and kidney , while the Alkaline Phosphatase activity was increased in kidney , lung and liver . The results were indicated that no significant differences ( P > 0.05 ) in Glutamate Pyruvate Transaminase activity between the treatment of mice with cadmium ( II ) complex and cyclophosphamide (CP) in the liver , kidney and Alkaline Phosphatase activity in the liver at each three doses .

scholarly journals The influence of menopause and body mass index on serum leptin concentrations

2000 ◽  
pp. 55-60 ◽  
Author(s):  
P Hadji ◽  
O Hars ◽  
K Bock ◽  
G Sturm ◽  
T Bauer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Leptin

OBJECTIVE: The aim of this study was to evaluate the influence of menopausal status, serum estradiol and body mass index (BMI) on serum leptin concentration in a large sample of pre- and postmenopausal women. DESIGN: 434 healthy women (mean age +/-s.d., 52.2 +/- 10.3 years) were recruited at the University of Marburg on the occasion of a routine gynecological visit. Two hundred and eighteen (50.2%) women were premenopausal (mean age, 36.5 +/- 10.4 years) and not on oral contraceptives or hormone replacement therapy (HRT) and 216 (49.8%) women were postmenopausal (mean age 61.8 +/- 8.9 years) not on HRT. To evaluate the influence of menopausal status, estradiol level and BMI on serum leptin concentrations, women were allocated to one of the four groups: (a) premenopausal women BMI <25 kg/m(2) (n=137), (b) premenopausal women BMI >25 kg/m(2) (n=81), (c) postmenopausal women BMI <25 kg/m(2) (n=94) and (d) postmenopausal women BMI >25 kg/m(2) (n=122). RESULTS: Irrespective of the menopausal status, women with a BMI >25 kg/m(2) had significantly higher leptin concentrations in all age groups compared with women with a BMI <25 kg/m(2) (P<0.001). The multiple linear regression analyses showed that BMI was the only statistically significant independent predictor for leptin. In comparison to postmenopausal women, premenopausal women showed a significantly lower mean age, weight, BMI and FSH concentration (P<0. 001), a higher mean height and serum estradiol (P<0.01 and P<0.001 respectively) but significantly lower serum leptin concentration (P<0.01). The multiple linear regression model showed no significant influence of menopausal status or serum estradiol on serum leptin concentration, even after controlling for BMI. CONCLUSIONS: Serum leptin concentrations are significantly higher in pre- and postmenopausal obese women, compared with normal weight controls. Serum leptin concentrations are not influenced by menopausal status or serum estradiol level.

scholarly journals The impact of body mass index on breast cancer incidence among women at increased risk: an observational study from the International Breast Intervention Studies

2021 ◽  
Author(s):  
Samuel G. Smith ◽  
Ivana Sestak ◽  
Michelle. A. Morris ◽  
Michelle Harvie ◽  
Anthony Howell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Treatment Group ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Intervention Studies ◽  
Premenopausal Women ◽  
Increased Risk

Abstract Background We investigated the association between body mass index (BMI) and breast cancer risk in women at increased risk of breast cancer receiving tamoxifen or anastrozole compared with placebo using data from the International Breast Cancer Intervention Studies [IBIS-I (tamoxifen) and IBIS-II (anastrozole)]. Methods Baseline BMI was calculated from nurse assessed height and weight measurements for premenopausal (n = 3138) and postmenopausal (n = 3731) women in IBIS-I and postmenopausal women in IBIS-II (n = 3787). The primary endpoint was any breast cancer event (invasive and ductal carcinoma in situ). We used Cox proportional hazards regression to calculate hazard ratios (HRs) for risk after adjustment for covariates. Results There were 582 (IBIS-I) and 248 (IBIS-II) breast cancer events [median follow-up = 16.2 years (IQR 14.4–17.7) and 10.9 years (IQR 8.8–13.0), respectively]. In adjusted analysis, women with a higher BMI had an increased breast cancer risk in both IBIS-I [HR = 1.06 per 5 kg/m2 (0.99–1.15), p = 0.114] and in IBIS-II [HR per 5 kg/m2 = 1.21 (1.09–1.35), p < 0.001]. In IBIS-I, the association between BMI and breast cancer risk was positive in postmenopausal women [adjusted HR per 5 kg/m2 = 1.14 (1.03–1.26), p = 0.01] but not premenopausal women [adjusted HR per 5 kg/m2 = 0.97 (0.86–1.09), p = 0.628]. There was no interaction between BMI and treatment group for breast cancer risk in either IBIS-I (p = 0.62) or IBIS-II (p = 0.55). Conclusions Higher BMI is associated with greater breast cancer risk in postmenopausal women at increased risk of the disease, but no effect was observed in premenopausal women. The lack of interaction between BMI and treatment group on breast cancer risk suggests women are likely to experience benefit from preventive therapy regardless of their BMI. Trial registration Both trials were registered [IBIS-I: ISRCTN91879928 on 24/02/2006, retrospectively registered (http://www.isrctn.com/ISRCTN91879928); IBIS-II: ISRCTN31488319 on 07/01/2005, retrospectively registered (http://www.isrctn.com/ISRCTN31488319)]

LEUCOCYTE METABOLISM IN PREGNANCY

1960 ◽  
Vol XXXV (IV) ◽  
pp. 575-584 ◽  
Author(s):  
C. Borel ◽  
J. Frei ◽  
A. Vannotti
Keyword(s):  
Alkaline Phosphatase ◽  
Oxygen Consumption ◽  
Pregnant Women ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Lactate Production ◽  
Glucose Consumption ◽  
In Pregnancy

ABSTRACT Enzymatic studies, on leucocytes of pregnant women, show an increase of the alkaline phosphatase activity and a decrease of the glucose consumption and lactate production, as well as of proteolysis. The oxygen consumption, with succinate as substrate, does not vary.

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