scholarly journals A topological look into the evolution of developmental programs

Author(s):  
Somya Mani ◽  
Tsvi Tlusty
1972 ◽  
Author(s):  
Dottie Bellinger ◽  
Craig Boswell ◽  
Brenda Shrank ◽  
Beth Harwood ◽  
Patricia Riley ◽  
...  

2009 ◽  
Vol 18 (1) ◽  
pp. 28-41 ◽  
Author(s):  
Stacy Warner ◽  
Marlene A. Dixon ◽  
Christyn Schumann

Physical activity and sport developmental programs have demonstrated some success at providing valuable resources for young women as they navigate their teen years, yet these programs are not always intentional and/or accessible (Cadwallader, 2001; Petitpas, Cornelius, Van Raalte, & Jones, 2004; Tucker Center, 2007). One such program developed by the Women’s Sports Foundation is GoGirlGo. The curriculum, which combines sports participation with education, focuses on reducing and preventing unhealthy behaviors and on providing valuable connections and resources for girls. Using the theory of developmental intentionality, this qualitative investigation examined the efficacy of GoGirlGo in a five day long sport camp setting. This condensed delivery method is not addressed or recommended in the literature, yet the results of this investigation reveal that this delivery method is effective and could broaden the accessibility of the program.


2021 ◽  
Vol 9 (08) ◽  
pp. 896-899
Author(s):  
Bontha Ambedkar ◽  
◽  
V. DivyaThejomurthy ◽  

The Scheduled Castes, according to the 2011 census, are 20.13 crores and constitute 16.6 per cent of the total population of the country and have long suffered from extreme social and economic backwardness. The Scheduled Castes category comprises many castes which share certain common handicaps in relation to the rest of the castes in society. They are quite distinct in caste hierarchy. They are economically dependent, educationally backward, politically suppressed, and socially the worst sufferers. Further they were classed as untouchables. The term scheduled castes refers to a list of castes prepared in 1935 by the British Government in India. But during the ancient period and medieval period they were known as Panchamas (fifth group), Chandalas (heathens or outeastes) and Antyajas (lowest class), and during the British period they came to be called first as Depressed Classes (dalitjatis) or Exterior Castes (avarnas), later as Harijans (children of God), and finally as Scheduled Castes (castes listed in the Government Schedule Article 341).


2021 ◽  
Author(s):  
Sarah Watson ◽  
Collette LaVigne ◽  
Lin Xu ◽  
Whitney Murchison ◽  
Didier Surdez ◽  
...  

Clinical sequencing efforts are uncovering numerous fusion genes in childhood solid tumors, yet few methods exist to delineate fusion-oncogenes from structural changes of unknown significance. One such novel fusion gene is VGLL2-NCOA2, which was described by us and others in patients with congenital sarcomas but has lacked functional validation. To determine if this fusion is an oncogene, and how it is driving disease, we developed a vertebrate zebrafish model and mouse allograft model of human VGLL2-NCOA2 driven sarcomagenesis. We found that VGLL2-NCOA2 is indeed an oncogene and is sufficient to generate mesenchymal tumors that recapitulate the human disease at the histological and transcriptional level. Zebrafish VGLL2-NCOA2 tumors display features of arrested skeletal muscle development, and a subset transcriptionally cluster with somitogenesis in developing embryos. By comparing tumor and embryonic gene expression signatures, we identified developmentally regulated targets that VGLL2-NCOA2 potentially leverages for tumorigenesis. These targets highlight the core biology of the disease and could represent therapeutic opportunities. Specifically, a RAS family GTPase, arf6/ARF6, involved in actin remodeling and rapid cycling of endocytic vesicles at the plasma membrane, is highly expressed during zebrafish somitogenesis and in VGLL2-NCOA2 tumors. In zebrafish tumors, arf6 protein is highly expressed and is absent from mature skeletal muscle. In VGLL2-NCOA2 mouse allograft models and patient tumors, ARF6 mRNA is overexpressed as compared to skeletal muscle or normal controls. More broadly, ARF6 is overexpressed in adult and pediatric sarcoma subtypes as compared to mature skeletal muscle. Overall, our cross-species comparative oncology approach provides evidence that VGLL2-NCOA2 is an oncogene which leverages developmental programs for tumorigenesis, and that one of these programs, the reactivation or persistence of arf6/ARF6, could represent a therapeutic opportunity.


Author(s):  
Balogh László

Három évtizeddel ezelőtt jelentős változások kezdődtek a hazai tehetséggondozásban. A tanulmány első részében ennek főbb társadalmi és tehetségpedagógiai okait elemzi a szerző. Ezt követően arról olvashatunk, hogy mi jellemzi napjainkban az egyéni tehetségfejlesztő programokat pedagógiai és pszichológiai szempontból, miben kell még fejlődnünk. A szerző bemutat egy általa készített új folyamatmodellt, amely szempontokat ad a rendszerszerű egyéni fejlesztő programok kidolgozásához. A harmadik fejezetben az utóbbi tíz év állam által finanszírozott átfogó nemzeti tehetséggondozó programjairól kapunk képet, azok eredményeivel együtt.Thirty years ago important changes emerged in gifted education in Hungary. In the first part of the present study the author analyses the main reasons of it in the society and in the official system of gifted education. In the second part we can read about the individual developmental programs of the gifted education: what we have to do to develop on a higher level in this work? The author presents a new process-modell, made by himself which gives points of views to plan and to realize systematical individual gifted developmental programs. Finally we get picture of the „big gifted education programs” – financed by the Hungarian State last ten years – and about the main results of these programs.


Author(s):  
Michael J. Marquardt ◽  
H. Skipton Leonard ◽  
Arthur M. Freedman ◽  
Claudia C. Hill

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