Iminoboronate – chitooligosaccharides hydrogels with strong antimicrobial activity for biomedical applications

Abstract The aim of this study was to investigate the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of organic acid salts against six field isolates of Streptococcus suis. The three products evaluated were sodium salt of coconut fatty acids distillate (DIC) alone and two combinations with sodium butyrate (NaBut): DIC70:30, being 70% of NaBut protected with 30% of DIC; and DIC50:50, being 50% of NaBut protected with 50% of DIC. Antimicrobial susceptibility testing was performed to estimate the MIC values for each product and strain by the broth microdilution method at pH 6.0. MBC values were also determined by sub-culturing supernatant from wells without evident bacterial growth. The values of MIC50/MBC50 were calculated as the concentration which inhibited/killed 50% of the isolates tested. The MIC50 showed DIC as the most effective (8 ppm) against S. suis followed by DIC50:50 (32 ppm) and DIC70:30 (64 ppm). The MBC50 demonstrated a similar trend, DIC being the most effective (16 ppm) followed by DIC50:50 (64 ppm) and DIC70:30 (64 ppm). It is well known that butyric acid is a short-chain fatty acid which has strong antimicrobial activity against Gram-negative bacteria. In contrast, coconut fatty acids distillate is a medium-chain fatty acid source (MCFA) rich in lauric acid which has strong antimicrobial activity against Gram-positive bacteria. Both products are generally available as salts to facilitate their application in feed. In this study, the results showed that DIC was the most effective against the Gram-positive bacteria tested, followed by DIC50:50 and DIC70:30, the sodium butyrate-based products. As expected, a higher concentration of MCFA in the tested product was associated with a higher inhibitory and bactericidal activity. Further studies would be required to better understand these interactions as well as in vivo studies to demonstrate the effects on microbial populations.

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Anti-Avian Influenza Virus Properties of Ortho dichlorobenzene Cresol Complex Formulation with Strong Antimicrobial Activity

Journal of the Japan Veterinary Medical Association ◽

10.12935/jvma.72.205 ◽

2019 ◽

Vol 72 (4) ◽

pp. 205-209

Author(s):

Toshiyo YABUTA ◽

Koichi OTSUKI ◽

Hiroki TAKAKUWA ◽

Hiroki KOMATSU

Keyword(s):

Antimicrobial Activity ◽

Influenza Virus ◽

Avian Influenza ◽

Avian Influenza Virus ◽

Complex Formulation ◽

Strong Antimicrobial Activity

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Combined Effect of Hop Resins and Sodium Hexametaphosphate against Certain Strains of Escherichia coli

Journal of Food Protection ◽

10.4315/0362-028x-63.6.735 ◽

2000 ◽

Vol 63 (6) ◽

pp. 735-740 ◽

Cited By ~ 7

Author(s):

TADASHI FUKAO ◽

HARUMICHI SAWADA ◽

YOSHIYUKI OHTA

Keyword(s):

Escherichia Coli ◽

Antimicrobial Activity ◽

Food Systems ◽

Combined Effect ◽

Sodium Hexametaphosphate ◽

Lag Phase ◽

Phase Growth ◽

E Coli ◽

Cell Components ◽

Strong Antimicrobial Activity

The combined antimicrobial effects of hop resins with sodium hexametaphosphate, glycerol monocaprate, and lysozyme were investigated aiming to make an effective agent against Escherichia coli. When they are used separately, the antimicrobial activity against E. coli was minimal. However, the combination of hop resins with sodium hexametaphosphate exhibited strong antimicrobial activity against E. coli, but no effect was found in combinations of hop resins with the other agents. The activity was strongest when the combination was added at the beginning of growth of the bacteria, resulting in a prolonged lag phase. However, when the antimicrobials were added during the log phase, growth was depressed considerably. By addition of these materials, cell components with absorbance near 260 nm were leaked out. This possibly may have resulted from damage to the cell membranes of the bacteria. The combined effect was also detected in model food systems such as mashed potatos. The use of hop resins and sodium hexametaphosphate in combination may thus be useful for controlling E. coli.

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Influence of High Annealing Temperature on Structural, Magnetic and Antimicrobial Activity of Silver Chromite Nanoparticles for Biomedical Applications

Journal of Inorganic and Organometallic Polymers and Materials ◽

10.1007/s10904-019-01306-w ◽

2019 ◽

Vol 30 (5) ◽

pp. 1821-1828 ◽

Cited By ~ 7

Author(s):

Asmaa A. H. El-Bassuony

Keyword(s):

Antimicrobial Activity ◽

Biomedical Applications ◽

Annealing Temperature ◽

High Annealing Temperature ◽

High Annealing

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Antimicrobial Activity and HPLC Fingerprinting of CrudeOcimumExtracts

E-Journal of Chemistry ◽

10.1155/2011/428019 ◽

2011 ◽

Vol 8 (3) ◽

pp. 1430-1437 ◽

Cited By ~ 3

Author(s):

S. S. Deo ◽

F. Inam ◽

R. P. Mahashabde

Keyword(s):

Antimicrobial Activity ◽

Methanolic Extract ◽

Ocimum Sanctum ◽

Moderate Activity ◽

Aqueous Extracts ◽

Gram Positive ◽

Strong Activity ◽

Gram Negative ◽

E Coli ◽

Strong Antimicrobial Activity

The antimicrobial activity of crude methanolic and aqueous extracts ofOcimum sanctumandOcimum kilimandsacharicumagainst gram positive, gram negative and antifungal activity was evaluated to find the zone of inhibition and to set a HPLC profile or fingerprint of these extracts. The crude methanolic extract ofOcimum sanctumshowed strong antimicrobial activity againstS.aureusandC. albicansand moderate activity againstE. coliandB. subtilis. The crude methanolic extract ofOcimum kilimandsacharicumshowed strong antimicrobial activity againstS. aureus, E. coliandC. albicansat higher concentration, same as that shown by the standard forC. albicans. It showed moderate activity againstB. subtilis. The crude aqueous extracts of Ocimum sanctum showed strong antimicrobial activity againstS.aureusand moderate against others. Whereas the crude aqueous extracts ofOcimum kilimandsacharicumshowed moderate activity against the gram positive and gram negative organisms and strong activity againstC. albicansat higher concentration, same as that shown by the standard forC. albicans.

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Characterization and Antimicrobial Activities of a Metabolite from a New Streptomyces Species from Bangladeshi Soil

Journal of Scientific Research ◽

10.3329/jsr.v2i1.3079 ◽

2009 ◽

Vol 2 (1) ◽

pp. 178-185

Author(s):

M. Akhand ◽

M. A. A. Al-Bari ◽

M. A. Islam ◽

Proma Khondkar

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Activities ◽

Assay Method ◽

Streptomyces Species ◽

Isolation And Characterization ◽

Test Organisms ◽

Actinomycete Strain ◽

Diffusion Assay ◽

Strong Antimicrobial Activity

A new actinomycete strain was isolated from Western part of Bangladesh and identified as a new Streptomyces species on the basis of its morphological, biochemical, cultural characteristics and 16S rRNA data. The present paper describes the isolation and characterization of compound 1 from this new Streptomyces species with the help of various chemical and spectroscopic methods. Antimicrobial activity of compound 1 was tested by disc diffusion assay method and compared with that of standard antibiotics (Kanamycin for antibacterial activity and Nystatin for antifungal activity). The compound has been found to exhibit moderate to strong antimicrobial activity against the test organisms. Cytotoxicity of the compound 1 and the pet. ether extract of Czapek Dox (alkaline) broth of Streptomyces species was evaluated in brine shrimp bioassay with LC50 values of 23.85 µg/ml (ppm) and 19.95 µg/ml (ppm), respectively. Keywords: Streptomyces; Antimicrobial activity; Cytotoxicity. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i1.3079 J. Sci. Res. 2 (1), 178-185 (2010)

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Collagen-Based Materials Modified by Phenolic Acids—A Review

Materials ◽

10.3390/ma13163641 ◽

2020 ◽

Vol 13 (16) ◽

pp. 3641

Author(s):

Beata Kaczmarek ◽

Olha Mazur

Keyword(s):

Antimicrobial Activity ◽

Hydrogen Bonds ◽

Phenolic Acids ◽

Biomedical Applications ◽

Present Knowledge ◽

Polymeric Chain ◽

Mechanical Parameters ◽

Research Reporting ◽

Pure Collagen ◽

Different Types

Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Synthesis of Cinnamanilide Derivatives and Their Antioxidant and Antimicrobial Activity

Journal of Chemistry ◽

10.1155/2015/208910 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 9

Author(s):

Satish Balasaheb Nimse ◽

Dilipkumar Pal ◽

Avijit Mazumder ◽

Rupa Mazumder

Keyword(s):

Antimicrobial Activity ◽

Cinnamic Acid ◽

Antioxidant Activities ◽

Gram Negative Bacteria ◽

Bacterial Strains ◽

Strong Activity ◽

Amide Derivatives ◽

Antioxidant And Antimicrobial Activity ◽

Derivatives Of ◽

Strong Antimicrobial Activity

The amide derivatives of cinnamic acid were synthesized and their antimicrobial and antioxidant activities were investigated. The investigation of antimicrobial potentials of the compounds demonstrated a strong activity against 21 bacterial strains comprising Gram-positive and Gram-negative bacteria. Compounds2a,2b, and3bshowed strong antimicrobial activity against all microorganisms with the pMIC value ranging from 2.45 to 3.68. Compounds2a,3a, and3bdemonstrated strong antioxidant activity with % inhibition of the DPPH radical of 51% (±1.14), 41% (±1.01), and 50% (±1.23), respectively. These findings indicate that the amide derivatives of the cinnamic acid possess strong antibacterial and antioxidant activities.

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