Collagen-Based Materials Modified by Phenolic Acids—A Review

Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria

Research in Microbiology ◽

10.1016/j.resmic.2010.04.006 ◽

2010 ◽

Vol 161 (5) ◽

pp. 372-382 ◽

Cited By ~ 214

Author(s):

Carolina Cueva ◽

M. Victoria Moreno-Arribas ◽

Pedro J. Martín-Álvarez ◽

Gerald Bills ◽

M. Francisca Vicente ◽

...

Keyword(s):

Antimicrobial Activity ◽

Phenolic Acids ◽

Pathogenic Bacteria

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A high-density nanowire electrode on paper for biomedical applications

RSC Advances ◽

10.1039/c4ra12373e ◽

2015 ◽

Vol 5 (12) ◽

pp. 8680-8687 ◽

Cited By ~ 26

Author(s):

P. Mostafalu ◽

S. Sonkusale

Keyword(s):

Biomedical Applications ◽

High Density ◽

Different Types ◽

Paper Substrates

Different types of nanowires made from platinum, nickel and copper are fabricated and patterned with microscale resolution on paper substrates and employed for biomedical applications.

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Crystal structure of a polymeric calcium levulinate dihydrate:catena-poly[[diaquacalcium]-bis(μ2-4-oxobutanoato)]

Acta Crystallographica Section E Crystallographic Communications ◽

10.1107/s2056989015006696 ◽

2015 ◽

Vol 71 (5) ◽

pp. 494-497

Author(s):

Ananda S. Amarasekara ◽

Dominique T. Sterling-Wells ◽

Carlos Ordonez ◽

Marie-Josiane Ohoueu ◽

Marina S. Fonari

Keyword(s):

Hydrogen Bonds ◽

Rotation Axis ◽

Three Dimensional ◽

Axial Direction ◽

Chain Structure ◽

Dimensional Structure ◽

Polymeric Chain ◽

Water Molecules ◽

Carboxylate Ligands ◽

Length Range

In the title calcium levulinate complex, [Ca(C5H7O3)2(H2O)2]n, the Ca2+ion lies on a twofold rotation axis and is octacoordinated by two aqua ligands and six O atoms from four symmetry-related carboxylate ligands, giving a distorted square-antiprismatic coordination stereochemistry [Ca—O bond-length range = 2.355 (1)–2.599 (1) Å]. The levulinate ligands act both in a bidentate carboxylO,O′-chelate mode and in a bridging mode through one carboxyl O atom with an inversion-related Ca2+atom, giving a Ca...Ca separation of 4.0326 (7) Å. A coordination polymeric chain structure is generated, extending along thec-axial direction. The coordinating water molecules act as double donors and participate in intra-chain O—H...O hydrogen bonds with carboxyl O atoms, and in inter-chain O—H...O hydrogen bonds with carbonyl O atoms, thus forming an overall three-dimensional structure.

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Surface Modification of Gold Nanostars Through the Changes on Gold Seed Concentrations

MRS Advances ◽

10.1557/adv.2018.329 ◽

2018 ◽

Vol 3 (41) ◽

pp. 2449-2454

Author(s):

Juan Carlos Martinez Espinosa ◽

Miguel Jose Yacaman ◽

German Plascencia Villa ◽

Victor Hugo Romero Arellano ◽

Ana Karen Zavala Raya

Keyword(s):

Biomedical Applications ◽

Surface Enhanced Raman Spectroscopy ◽

Diameter Distribution ◽

Biological Assays ◽

Surface Enhanced ◽

Different Types ◽

Surface Enhanced Raman ◽

Gold Seed ◽

Gold Nanomaterials ◽

Specific Membrane

AbstractDue to its excellent optical properties, gold nanomaterials with anisotropic morphology are playing an important role in biomedical applications, specifically in the use of Surface Enhanced Raman Spectroscopy (SERS) technique for biological assays. In this work, we verified the behavior of the star shape nanoparticle peaks obtained by chemical synthesis (precursor reactant: HAuCl4, cationic surfactant: CTAB) and whose peaks were formed from the different concentrations of gold seeds (55, 65, 75 and 85 ul) which were added to the total solution (5.275 ml). The shape and size of the nanoparticles was verified with a Hitachi S-5500 microscope with a BF & DF SEM / STEM detector, and for the diameter distribution (hydrodynamic) was carried out by the dynamic light distribution technique with a Malvern DLS system Zetasizer Nano ZS. Particle sizes (peak-to-peak considering) were obtained with variations from 107 to 166 nm. The results suggest adding 75 ul of gold seeds to obtain uniform nanostars with well defined peaks. These gold nano-stars could be applied for identification of specific membrane markers for the study of different types of cancer by the SERS technique.

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Applications of Nanomaterials for Activation and Suppression of Immune Responses

Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering - Advances in Chemical and Materials Engineering ◽

10.4018/978-1-4666-6363-3.ch011 ◽

2015 ◽

pp. 205-220

Author(s):

Akhilesh Kumar Shakya ◽

Kutty Selva Nandakumar

Keyword(s):

Side Effects ◽

Immune Responses ◽

Biomedical Applications ◽

Inflammatory Diseases ◽

Host Proteins ◽

Different Types ◽

Potential Therapeutics

Evaluation of immuno-modulating properties of nanomaterials is important to develop new potential therapeutics for inflammatory diseases and cancer. Activation and suppressive effects of nanomaterials on immune responses occur through various interactions with different host proteins. They can also be engineered as carriers and/or adjuvants for different proteins or antigens. Particles, emulsions, and tubes/rods are the major formats of nanomaterials currently used in biomedical applications. Sometimes, nanomaterials induce side effects like undesired immunosuppression and toxicities, which are major concerns at present in designing optimal nanotherapeutics. This chapter summarizes different types of nanomaterials and their effect on immune responses.

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EFFECT OF IMMOBILIZATION ON THE EXCITATORY AND MECHANICAL PARAMETERS OF SKELETAL MUSCLES WITH DIFFERENT TYPES

Gravitational Physiology ◽

10.1016/b978-0-08-027340-2.50031-6 ◽

1981 ◽

pp. 185-188

Author(s):

A. Török ◽

I. Sziklai ◽

F. Guba ◽

Ö. Takács

Keyword(s):

Skeletal Muscles ◽

Mechanical Parameters ◽

Different Types

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Applications of Nanomaterials for Activation and Suppression of Immune Responses

Materials Science and Engineering ◽

10.4018/978-1-5225-1798-6.ch034 ◽

2017 ◽

pp. 859-875

Author(s):

Akhilesh Kumar Shakya ◽

Kutty Selva Nandakumar

Keyword(s):

Side Effects ◽

Immune Responses ◽

Biomedical Applications ◽

Inflammatory Diseases ◽

Host Proteins ◽

Different Types ◽

Potential Therapeutics

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Plasma and Nanomaterials: Fabrication and Biomedical Applications

Nanomaterials ◽

10.3390/nano9010098 ◽

2019 ◽

Vol 9 (1) ◽

pp. 98 ◽

Cited By ~ 26

Author(s):

Nagendra Kaushik ◽

Neha Kaushik ◽

Nguyen Linh ◽

Bhagirath Ghimire ◽

Anchalee Pengkit ◽

...

Keyword(s):

Thermal Plasma ◽

Reactive Nitrogen Species ◽

Biomedical Applications ◽

Medical Personnel ◽

Plasma Jets ◽

Dielectric Barrier Discharges ◽

Different Types ◽

Non Thermal Plasma ◽

Review Reports ◽

Barrier Discharges

Application of plasma medicine has been actively explored during last several years. Treating every type of cancer remains a difficult task for medical personnel due to the wide variety of cancer cell selectivity. Research in advanced plasma physics has led to the development of different types of non-thermal plasma devices, such as plasma jets, and dielectric barrier discharges. Non-thermal plasma generates many charged particles and reactive species when brought into contact with biological samples. The main constituents include reactive nitrogen species, reactive oxygen species, and plasma ultra-violets. These species can be applied to synthesize biologically important nanomaterials or can be used with nanomaterials for various kinds of biomedical applications to improve human health. This review reports recent updates on plasma-based synthesis of biologically important nanomaterials and synergy of plasma with nanomaterials for various kind of biological applications.

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Comparative evaluation of antimicrobial activity of different types of ionic liquids

Materials Science and Engineering C ◽

10.1016/j.msec.2019.109907 ◽

2019 ◽

Vol 104 ◽

pp. 109907 ◽

Cited By ~ 5

Author(s):

Walter Florio ◽

Stefano Becherini ◽

Felicia D'Andrea ◽

Antonella Lupetti ◽

Cinzia Chiappe ◽

...

Keyword(s):

Antimicrobial Activity ◽

Ionic Liquids ◽

Comparative Evaluation ◽

Different Types

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Phytochemical Investigations of Laurel Fruits (Laurus nobilis)

Natural Product Communications ◽

10.1177/1934578x19868876 ◽

2019 ◽

Vol 14 (8) ◽

pp. 1934578X1986887

Author(s):

Zhana Petkova ◽

Galina Stefanova ◽

Tania Girova ◽

Ginka Antova ◽

Magdalena Stoyanova ◽

...

Keyword(s):

Antimicrobial Activity ◽

Phenolic Acids ◽

Vanillic Acid ◽

Lipid Fraction ◽

Syringic Acid ◽

Dominant Group ◽

Laurus Nobilis ◽

Lipid Fractions ◽

Dimorphic Yeast ◽

Valuable Compounds

Bay laurel ( Laurus nobilis L.) is an evergreen tree. The objective of this study was to determine the chemical composition (polyphenols, essential oil [EO], lipid fraction, cellulose, and protein content) of laurel fruits collected from Greece (Mount Athos) and Georgia (the village of Meria), and to evaluate the antimicrobial activity of laurel fruit EOs. The major phenolic acids in the fruits from Greece were p-coumaric acid (free 261.6 µg/g) and vanillic acid (free 253.1 µg/g and conjugated 925.8 µg/g). The major phenolic acids in fruits from Georgia were vanillic acid (free 105.6 µg/g and caffeic acid [conjugated 439.2 µg/g], and syringic acid [conjugated 390.7 µg/g]). The laurel fruit EOs from Greece (1.4% content) and Georgia (1.6%) had distinct composition. Monoterpene hydrocarbons were the dominant group of compounds in the EOs, with 49.7% in the EO from Greece and 68.7% in the EO from Georgia. The major constituents of the fruit EO from Greece were 1,8-cineole (18.2%), α-phellandrene (15.0 %), β-pinene (9.4%), and α -pinene (9.1%), whereas the ones from Georgia were trans-β-ocimene (59.4%) and 1,8-cineole (7.6%). Laurel fruit EO from Greece and Georgia demonstrated low to moderate antimicrobial activity against pathogenic and spoilage microorganisms and the dimorphic yeast Candida albicans. The main fatty acids (FAs) in the lipid fractions were oleic, palmitic, and linoleic; there were differences in FA composition between the shells and the seeds of the fruits from the two countries. γ-Тocopherol predominated in the tocopherol fraction of the lipids from fruits shells and seeds from Greece (65.3% and 54.4%, respectively), whereas β-tocopherol predominated in fruits shells and seeds from Georgia (93.7% and 45.6%, respectively). Currently underutilized, the laurel fruits from both Greece and Georgia contain various valuable compounds that may potentially be used for perfumery, cosmetic, and pharmaceutical applications.

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