Clinical Characteristics, Management, and Outcomes of Hospitalized Heart Failure in a Chinese Population—The Hong Kong Heart Failure Registry

2016 ◽  
Vol 22 (8) ◽  
pp. 600-608 ◽  
Author(s):  
Jo-Jo Hai ◽  
Pak-Hei Chan ◽  
Duo Huang ◽  
Mei-Han Ho ◽  
Chi-Wai Ho ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hong Kong ◽  
Chinese Population ◽  
Clinical Characteristics

The aetiology of heart failure in the Chinese population of Hong Kong — a prospective study of 730 consecutive patients

1995 ◽  
Vol 51 (1) ◽  
pp. 29-35 ◽  
Author(s):  
John E. Sanderson ◽  
Skiva K.W. Chan ◽  
Wilson W.M. Chan ◽  
Yu T. Hung ◽  
Kam S. Woo
Keyword(s):  
Heart Failure ◽  
Hong Kong ◽  
Prospective Study ◽  
Chinese Population ◽  
A Prospective Study

scholarly journals P0772CLINICAL CHARACTERISTICS OF THE UK CHINESE POPULATION WITH KIDNEY FAILURE: A UK RENAL REGISTRY ANALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Katie Wong ◽  
Fergus Caskey ◽  
Yoav Ben-Shlomo ◽  
Anna Casula ◽  
Pippa Bailey
Keyword(s):  
Socioeconomic Status ◽  
Hong Kong ◽  
Renal Disease ◽  
Chinese Population ◽  
Clinical Characteristics ◽  
Chinese Diaspora ◽  
Chinese Patients ◽  
White Population ◽  
Chinese Ethnicity ◽  
The Uk

Abstract Background and Aims Data from the UK Renal Registry (UKRR) has shown that 0.5% of those in the UK with kidney failure are of Chinese ethnicity. The UK Chinese population is growing. Ethnic differences in cause of renal disease and dialysis rates have been described in UK individuals of White, South Asian, and Black ethnicity. However, the clinical demographics of the UK Chinese population with renal disease have not previously been investigated. The China Kidney Disease Network and the Hong Kong Renal Registry have reported the main cause of chronic kidney disease in their populations is diabetes, but the causes of renal disease in other Chinese diaspora have not been well described. We investigated the clinical characteristics of the UK Chinese population on renal replacement therapy (RRT) as compared with the UK White RRT population in this UKRR analysis. Method Data on all adult patients >=18 years who started RRT between 1/1/97 and 31/12/16 were extracted from the UKRR. Patients with ethnicity recorded as anything other than “Chinese” or “White” were excluded from analysis. Patients with ethnicity data missing were also excluded. Socioeconomic status was measured using country-specific Index of Multiple Deprivation (IMD) quintiles derived from patients’ postcodes (1= most deprived, 5= least deprived). The Chi-square (*) and Mann-Whitney U (**) tests were used to compare baseline characteristics between Chinese and White ethnic groups. Results The dataset comprised of 92,857 incident RRT patients, of which 0.5% (n=501) were of Chinese ethnicity and 76% (n=70,575) were White. Clinical characteristics of the UK Chinese population as compared to the UK White population are presented in Table 1. UK Chinese patients were younger at start of RRT than white patients (61.4 years vs 65.6 years, p<0.001**). Any difference in the proportion of male patients (60.7% vs 63.0%, p=0.29*) or socioeconomic status (p=0.75*) between the two groups was consistent with chance. There were marked differences in the causes of renal disease: UK Chinese patients had more diabetic renal disease (29% versus 20%, p<0.001*) and glomerulonephritis that white patients (21% vs 13%, p<0.001*) There was modest evidence that more UK Chinese patients started RRT on peritoneal dialysis (PD) compared to the White population (26% vs 23%, p=0.01*) Conclusion We found evidence that the UK Chinese RRT population differs from the UK White RRT population. To our knowledge, this is the first study describing renal disease in the UK Chinese population, and one of the first to describe disease in the Chinese diaspora. Our finding of a greater burden of diabetes in the UK Chinese RRT population compared to the White RRT population may reflect the high prevalence of diabetes in the UK Chinese, as in mainland China and Hong Kong. Further investigation is needed to understand the causes behind the higher burden of glomerulonephritis in the UK Chinese population. The increased rates of PD in UK Chinese patients may be associated with lower average Body Mass Index (BMI) in the Chinese population. The quantity of missing BMI data in the UKRR dataset prevented investigation of this association. Hong Kong has had a successful “PD first” policy for >30 years. Familiarity with this as a mode of dialysis may have led to higher rates of PD in the UK Chinese population. Studies from Hong Kong have also suggested that lower dialysis volumes are required for Chinese PD patients, and that high transporter status is less common in their population. It would be beneficial to elucidate whether this is also the case in UK Chinese patients.

scholarly journals Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Xia ◽  
Chunyue Guo ◽  
Kuo Liu ◽  
Yunyi Xie ◽  
Han Cao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Chinese Population ◽  
Left Ventricular Mass Index ◽  
Mendelian Randomization ◽  
Left Ventricular ◽  
Han Chinese ◽  
Han Chinese Population ◽  
Internal Dimension

Abstract Background There is a well-documented empirical relationship between lipoprotein (a) [Lp(a)] and cardiovascular disease (CVD); however, causal evidence, especially from the Chinese population, is lacking. Therefore, this study aims to estimate the causal association between variants in genes affecting Lp(a) concentrations and CVD in people of Han Chinese ethnicity. Methods Two-sample Mendelian randomization analysis was used to assess the causal effect of Lp(a) concentrations on the risk of CVD. Summary statistics for Lp(a) variants were obtained from 1256 individuals in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei. Data on associations between single-nucleotide polymorphisms (SNPs) and CVD were obtained from recently published genome-wide association studies. Results Thirteen SNPs associated with Lp(a) levels in the Han Chinese population were used as instrumental variables. Genetically elevated Lp(a) was inversely associated with the risk of atrial fibrillation [odds ratio (OR), 0.94; 95% confidence interval (95%CI), 0.901–0.987; P = 0.012)], the risk of arrhythmia (OR, 0.96; 95%CI, 0.941–0.990; P = 0.005), the left ventricular mass index (OR, 0.97; 95%CI, 0.949–1.000; P = 0.048), and the left ventricular internal dimension in diastole (OR, 0.97; 95%CI, 0.950–0.997; P = 0.028) according to the inverse-variance weighted method. No significant association was observed for congestive heart failure (OR, 0.99; 95% CI, 0.950–1.038; P = 0.766), ischemic stroke (OR, 1.01; 95%CI, 0.981–1.046; P = 0.422), and left ventricular internal dimension in systole (OR, 0.98; 95%CI, 0.960–1.009; P = 0.214). Conclusions This study provided evidence that genetically elevated Lp(a) was inversely associated with atrial fibrillation, arrhythmia, the left ventricular mass index and the left ventricular internal dimension in diastole, but not with congestive heart failure, ischemic stroke, and the left ventricular internal dimension in systole in the Han Chinese population. Further research is needed to identify the mechanism underlying these results and determine whether genetically elevated Lp(a) increases the risk of coronary heart disease or other CVD subtypes.

scholarly journals Stigma, Discrimination, and Hate Crimes in Chinese-Speaking World amid Covid-19 Pandemic

2021 ◽  
Author(s):  
Jianhua Xu ◽  
Guyu Sun ◽  
Wei Cao ◽  
Wenyuan Fan ◽  
Zhihao Pan ◽  
...  
Keyword(s):  
Data Mining ◽  
Hong Kong ◽  
Political Ideology ◽  
Chinese Population ◽  
Early Stage ◽  
Chinese Language ◽  
Hate Crimes ◽  
Overseas Chinese ◽  
Mainland Chinese ◽  
Media Reports

AbstractThe Covid-19 pandemic has given rise to stigma, discrimination, and even hate crimes against various populations in the Chinese language–speaking world. Using interview data with victims, online observation, and the data mining of media reports, this paper investigated the changing targets of stigma from the outbreak of Covid-19 to early April 2020 when China had largely contained the first wave of Covid-19 within its border. We found that at the early stage of the pandemic, stigma was inflicted by some non-Hubei Chinese population onto Wuhan and Hubei residents, by some Hong Kong and Taiwan residents onto mainland Chinese, and by some Westerners towards overseas Chinese. With the number of cases outside China surpassing that in China, stigmatization was imposed by some Chinese onto Africans in China. We further explore how various factors, such as the fear of infection, food and mask culture, political ideology, and racism, affected the stigmatization of different victim groups. This study not only improved our understanding of how stigmatization happened in the Chinese-speaking world amid Covid-19 but also contributes to the literature of how sociopolitical factors may affect the production of hate crimes.

scholarly journals Weight loss early after discharge predicts the risk of rehospitalization in non-obese patients with heart failure preserved ejection fraction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Kamisaka ◽  
K Kamiya ◽  
K Iwatsu ◽  
N Iritani ◽  
Y Iida ◽  
...  
Keyword(s):  
Heart Failure ◽  
Weight Loss ◽  
Regression Analysis ◽  
Ejection Fraction ◽  
Associated Factors ◽  
Clinical Characteristics ◽  
Obese Patients ◽  
Preserved Ejection Fraction ◽  
Kaplan Meier ◽  
Worse Prognosis

Abstract Background Weight loss (WL) has been considered as a prognostic factor in heart failure with reduced ejection fraction (HFrEF). However, the prognosis and associated factors of WL in heart failure with preserved ejection fraction (HFpEF) have remained unclear. Purpose This study aimed to examine the prevalence, prognosis, and clinical characteristics of worse prognosis based on the identified WL after discharge in HFpEF. Methods The study was conducted as a part of a multicenter cohort study (Flagship). The cohort study enrolled ambulatory HF who hospitalized due to acute HF or exacerbation of chronic HF. Patients with severe cognitive, psychological disorders or readmitted within 6-month after discharge were excluded in the study. WL was defined as ≥5% weight loss in 6-month after discharge and HFpEF was defined as left ventricular ejection fraction (LVEF) ≥50% at discharge. Age, gender, etiology, prior HF hospitalization, New York Heart Association (NYHA) class, brain natriuretic peptide (BNP) or N-terminal-proBNP (NT-proBNP), anemia (hemoglobin; male <13g/dL, female <12g/dL), serum albumin, Geriatric Depression Scale, hand grip strength and comorbidities were collected at discharge. Patients were stratified according to their body mass index (BMI) at discharge as non-obese (BMI <25) or obese (BMI ≥25). We analyzed the association between WL and HF rehospitalization from 6 month to 2 years after discharge using Kaplan-Meier curve analysis and Cox regression analysis adjusted for age and gender, and clinical characteristics associated to worse prognosis in WL using logistic regression analysis adjusted for potential confounders in HFpEF. Results A total of 619 patients with HFpEF were included in the analysis. The prevalence of WL was 12.9% in 482 non-obese and 15.3% in 137 obese patients. During 2 years, 72 patients were readmitted for HF (non-obese: 48, obese: 24). WL in non-obese independently associated with poor prognosis (hazard ratio: 2.2: 95% confidence interval: 1.13–4.25) after adjustment for age and sex, while WL in obese patients did not. Logistic regression analysis chose age (odds ratio 1.02 per 1 year; 1.00–1.05), anemia (2.14; 1.32–3.48), and BNP ≥200pg/mL or NT-proBNP ≥900pg/mL (1.83; 1.18–2.86) as independent associated factors for worse prognosis of WL in non-obese patients. Conclusion In HFpEF, WL in early after discharge in non-obese elderly patients may be a prognostic indicator for HF rehospitalization. HF management including WL prevention along with controlling anemia is likely to improve prognosis in this population. Kaplan Meier survival curves Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): A Grant-in-Aid for Scientific Research (A) from the Japan Society for the Promotion of Science

scholarly journals Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giosafat Spitaleri ◽  
Josep Lupón ◽  
Mar Domingo ◽  
Evelyn Santiago-Vacas ◽  
Pau Codina ◽  
...  
Keyword(s):  
Heart Failure ◽  
Linear Regression ◽  
Cardiovascular Mortality ◽  
Clinical Characteristics ◽  
Real Life ◽  
Cardiovascular Death ◽  
Progressive Decrease ◽  
Mortality Trends ◽  
Heart Failure Unit ◽  
Ambulatory Patients

AbstractTo assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (mean age 66.4 ± 12.9 years, 71% men, 15.4% with preserved LVEF) admitted to a HF clinic from August 2001 to September 2018 were included in the study. Patients were divided into five quintiles (Q) according to the period of admission. Trends for all-cause and cardiovascular mortality from Q1 to Q5 were assessed by linear regression. Patients with LVEF < 50% had a progressive decrease in the rates of all-cause and cardiovascular death at 1 year (12.1% in Q1 to 6.5% in Q5, p = 0.003; and 8.4% in Q1 to 3.8% in Q5, p = 0.007, respectively) and 3 years (30.5% in Q1 to 17.0% in Q5, p = 0.003; and 23.9% in Q1 to 9.8% in Q5, p = 0.003, respectively). These trends remained significant after adjusting for clinical characteristics and risk. No significant trend in mortality was observed in patients with LVEF ≥ 50%. In a cohort of real-life ambulatory patients with HF, mortality progressively declined in patients with LVEF < 50%, but the same trend was not observed in patients with preserved LVEF.

Sign in / Sign up

Export Citation Format

Share Document