Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets

2010 ◽  
Vol 185 (3) ◽  
pp. 157-162 ◽  
Author(s):  
P. Dilkin ◽  
G. Direito ◽  
M.M.S. Simas ◽  
C.A. Mallmann ◽  
B. Corrêa
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Fusarium Verticillioides ◽  
Fumonisin B1 ◽  
Weaned Piglets ◽  
Toxicological Effects ◽  
Culture Material

scholarly journals Vitamin B12absorption in the neonatal piglet

1985 ◽  
Vol 54 (1) ◽  
pp. 245-255 ◽  
Author(s):  
N. M. F. Trugo ◽  
J. E. Ford ◽  
B. F. Sansom
Keyword(s):  
Oral Dose ◽  
Blood Plasma ◽  
Single Oral Dose ◽  
The Body ◽  
Whole Body ◽  
Vitamin B ◽  
Weaned Piglets ◽  
High Concentration ◽  
Neonatal Piglets ◽  
Natural Analogues

1. The vitamin B12in sows' milk is strongly attached to a specific ‘binder’ protein, which is present in excess. The influence of this ‘binder’ on the uptake and retention of cyanocobalamin and two natural analogues(cobinamide and Co-α-[2-methyladenyl]cobamide) was investigated with neonatal piglets.2. Retention of a single oral dose of cyano[58Co]cobalamin given before 7 d of age was consistently higher with suckled than with early-weaned piglets, as determined by measurement of whole-body radioactivity.3. Efficiency of retention declined with age, more rapidly in early-weaned than in suckled animals; when the dose was given at 14 d approximately 30% was retained by both groups.4. Distribution of the retained cyano[58Co]cobalamin within the body of the piglets was the same in both groups; about half was present in the liver.5. Foraging piglets may ingest adventitious vitamin B12and its analogues, which are present in the sow's faeces and in contaminated litter. The influence of the vitamin B12-binder in sows' milk on the uptake and retention of two non-cobalamin analogues, and the effects of the analogues on the uptake and retention of vitamin B12from 2 to 14 d after parturition, were investigated with early-weaned piglets.6. The analogues were detected in the liver but not in the body organs. They were also present in blood plasma, urine and bile, in high concentration relative to that of vitamin B12. The content of analogues in the liver was very small in relation to the amounts ingested, and much less than that of vitamin B12. There was no indication that the vitamin B12-binder in sows' milk influenced uptake and retention of the analogues, or that ingestion of analogues affected the content of vitamin B12in the body organs and fluids examined.

Fumonisin B1-4-producing capacity of Hungarian Fusarium verticillioides isolates

2010 ◽  
Vol 3 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Á. Szécsi ◽  
A. Szekeres ◽  
T. Bartók ◽  
G. Oros ◽  
M. Bartók ◽  
...  
Keyword(s):  
Fusarium Verticillioides ◽  
Fumonisin B1 ◽  
Cultural Characteristics ◽  
The Third ◽  
Rice Grains ◽  
Rp Hplc ◽  
Culture Material ◽  
Analytical Results ◽  
Different Sources

The fumonisin B1-4 (FB1-4) toxin-producing capacities of 60 strains of Fusarium verticillioides isolated in the main maize-cultivating areas of Hungary were screened on rice grains in vitro. The amounts of FB1, FB2, FB3 and FB4 in the extracts of the culture material were determined by RP-HPLC/ESI-IT MS without any sample clean-up. All F. verticillioides strains produced all analogues (FB1-4) of the fumonisin B series. The strains did not differ significantly in their cultural characteristics, though the analytical results allowed the distinction of three idiosyncratic FB1-4-producing chemotypes with characteristic proportions of the fumonisin B analogues. The dominant chemotype produced them in the sequence FB1 > FB2 > FB3 > FB4, with large amounts of FB1 and FB2. A second chemotype produced a higher amount of FB3 than of FB2, while the third chemotype produced large amounts of FB2 and FB4. The proportion of FB1 in the extracts was inversely correlated with the total FB yield. No differences in FB1-4 producing capacity were observed between strains isolated from various locations or different sources.

Toxicity of Fumonisin from Fusarium verticillioides Culture Material and Moniliformin from Fusarium fujikuroi Culture Material When Fed Singly and in Combination to Growing Barrows

2002 ◽  
Vol 65 (2) ◽  
pp. 373-377 ◽  
Author(s):  
ROGER B. HARVEY ◽  
THOMAS S. EDRINGTON ◽  
LEON F. KUBENA ◽  
GEORGE E. ROTTINGHAUS ◽  
JAMES R. TURK ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Fusarium Verticillioides ◽  
Fumonisin B1 ◽  
Diet Group ◽  
Fusarium Fujikuroi ◽  
Culture Material ◽  
Feed Control ◽  
Serum Biochemical

The effects of fumonisin B1 (FB1) from Fusarium verticillioides culture material and moniliformin from Fusarum fujikuroi culture material on growing barrows were evaluated. Four groups of six barrows (three replicates of two each; mean body weight, 11.1 kg) were fed diets containing 0 mg of FB1 and 0 mg of moniliformin per kg of feed (control), 100 mg of FB1 per kg of feed, 100 mg of moniliformin per kg of feed, and 100 mg of FB1 plus 100 mg of moniliformin per kg of feed. Barrows were fed these diets for 28 days. Body weight gain, feed efficiency, serum biochemical analytes, and hematological values were adversely affected by the FB1 and the FB1-plus-moniliformin diets. The moniliformin diet decreased body weight gain. Two barrows in the moniliformin diet group died, and two barrows in the FB1-plus-moniliformin diet group died. All deaths occurred during the first 6 days of the study. Mild to moderate lesions were observed microscopically in heart and lung tissues of the groups fed moniliformin and FB1 plus moniliformin and in liver tissues of the groups fed FB1 and FB1 plus moniliformin. Except for the acute mortality associated with the two diets containing moniliformin, clinical disease induced by the combined feeding of these two mycotoxins appears to be additive or less than additive and due primarily to the toxic expression of FB1.

A Rapid (48 hours) Thyroid Suppression Test using a Single Oral Dose of 100 of Triiodothyronine

1973 ◽  
Vol 12 (03) ◽  
pp. 218-224
Author(s):  
Elli Lakka - Papadodima ◽  
Constantin Ntalles ◽  
Denis Ikkos
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Suppression Test

Des mesurages répétés de la fixation thyroïdienne de 10 minutes du 132I injecté intraveineusement on été effectués sur 55 malades euthyroïdiens sans et avec goitre et sur 16 malades hyperthyreoïdiens par 4 jours consécutifs. Immédiatement après le premier mesurage tous les malades recevaient une dose unique oral de 100 μg de Triiodothyronine (T3). Les valeurs de fixation 24, 48 et 72 heures après le T3 (moyen ± déviation standard) étaient de 75 ± 1,7, 64 ± 1,8, et 67 ± 1,9 dans le groupe euthyroïdien et le 106 ± 2,6, 104 ± 2,2 et 108 ± 4,0 dans le groupe hyperthyroïdien, exprimés en pourcentage du groupe controle. 48 heures après T3 tous les personnes euthyroïdiens, sauf une, avaient des valeurs en dessous de 88% tandis que la valeur la plus basse des personnes hyperthyroïdiens ce jour était de 93%. La séparation des valeurs 48 heures des deux groupes était complète après avoir respecté l’influence de la première fixation sur la valeur 48 heures. On peut donc supposer q’un test thyroïdien de suppression utilisable en clinique peut-être effectué en 48 heures après une administration oral de 100 μg de T3 et mesurage de la fixation 10 minutes après l’injection du radioisotope.

Effect of Aspirin on the Thrombelastogram of Human Blood

1973 ◽  
Vol 30 (03) ◽  
pp. 494-498 ◽  
Author(s):  
G de Gaetano ◽  
J Vermylen
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Platelet Function ◽  
Human Blood ◽  
Platelet Rich Plasma ◽  
Plasma Samples ◽  
Release Reaction ◽  
Platelet Release

SummaryThrombelastograms of both native blood and re-calcified platelet-rich plasma samples taken from subjects given a single oral dose of aspirin (1 gram) were not significantly different from the pretreatment recordings. Aspirin also did not modify the thrombelastogram when preincubated in vitro with platelet-rich plasma at concentrations inhibiting the platelet “release reaction” by collagen. Thrombelastography therefore cannot evaluate the effect of aspirin on platelet function.

Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

1970 ◽  
Vol 31 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Paul D. Altland ◽  
Benjamin Highman ◽  
Milton G. Parker ◽  
Michael P. Dieter
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Serum Enzyme ◽  
Tissue Changes
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