Black phosphorus nanosheets-based stable drug delivery system via drug-self-stabilization for combined photothermal and chemo cancer therapy

2019 ◽  
Vol 375 ◽  
pp. 121917 ◽  
Author(s):  
Gan Liu ◽  
Hsiang-I Tsai ◽  
Xiaowei Zeng ◽  
Junyang Qi ◽  
Miaomiao Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Black Phosphorus ◽  
Self Stabilization

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals Black phosphorus nanosheet-based new drug delivery system for the anticancer agents: A review

2021 ◽  
Vol 16 (2) ◽  
pp. 014-027
Author(s):  
Chaitanya A. Gulhane ◽  
Adarsh R. Durge ◽  
Jagdish V. Manwar ◽  
Ravindra L. Bakal
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Anticancer Agents ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Black Phosphorus ◽  
New Drug ◽  
Traditional Drug

Cancer has been one among the main threats to the lives of citizenry for hundreds of years. Traditional drug therapy has certain defects such as poor targeting, easy degradation, high side effects, etc. Therefore, to enhance the treatment efficiency of anticancer agents, there is need of developing new drug delivery systems. Black phosphorus is a member of the 2D family, and it possess the potential to construct drug delivery system by virtue of its photothermal therapy, photodynamic therapy, and biodegradable properties. Due to their special structure BP are considered to be the best platform for drug delivery. They have shown large potential as near-infrared photothermal therapy agents and drug delivery for cancer therapy. The present review covered advances in BP- based drug delivery system along with its advantages and applications in cancer therapy.

Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Halloysite Nanotube ◽  
Anticancer Efficacy

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.

scholarly journals Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Therapy

Hypoxia-triggered gene therapy: a new drug delivery system to utilize photodynamic-induced hypoxia for synergistic cancer therapy

2018 ◽  
Vol 6 (40) ◽  
pp. 6424-6430 ◽  
Author(s):  
Caixia Huang ◽  
Jing Zheng ◽  
Dandan Ma ◽  
Na Liu ◽  
Cong Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Therapy ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug

An new drug delivery system to utilize the photodynamic-induced hypoxia for synergistic cancer therapy is proposed in this paper.

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