Biomimetic fabrication of icariin loaded nano hydroxyapatite reinforced bioactive porous scaffolds for bone regeneration

2020 ◽  
Vol 394 ◽  
pp. 124895 ◽  
Author(s):  
Yimin Hu ◽  
Shujun Cao ◽  
Jingdi Chen ◽  
Yao Zhao ◽  
Fupo He ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Porous Scaffolds ◽  
Biomimetic Fabrication

scholarly journals Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

2021 ◽  
Vol 10 (9) ◽  
pp. 1842
Author(s):  
Valentin Herber ◽  
Begüm Okutan ◽  
Georgios Antonoglou ◽  
Nicole G. Sommer ◽  
Michael Payer
Keyword(s):  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Modulus Of Elasticity ◽  
Bone Repair ◽  
Clinical Results ◽  
Porous Scaffolds ◽  
General Review ◽  
Synthetic Materials ◽  
Bone Preservation

Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration.

scholarly journals Porous scaffolds for bone regeneration

2020 ◽  
Vol 5 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Naghmeh Abbasi ◽  
Stephen Hamlet ◽  
Robert M. Love ◽  
Nam-Trung Nguyen
Keyword(s):  
Bone Regeneration ◽  
Porous Scaffolds

scholarly journals Uncultured Marrow Mononuclear Cells Delivered Within Fibrin Glue Hydrogels to Porous Scaffolds Enhance Bone Regeneration Within Critical-Sized Rat Cranial Defects

2010 ◽  
Vol 16 (12) ◽  
pp. 3555-3568 ◽  
Author(s):  
James D. Kretlow ◽  
Patrick P. Spicer ◽  
John A. Jansen ◽  
Charles A. Vacanti ◽  
F. Kurtis Kasper ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Fibrin Glue ◽  
Mononuclear Cells ◽  
Porous Scaffolds

scholarly journals Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4794
Author(s):  
Daniel Martinez-Marquez ◽  
Ylva Delmar ◽  
Shoujin Sun ◽  
Rodney A. Stewart
Keyword(s):  
Bone Regeneration ◽  
Design Process ◽  
Quality By Design ◽  
Biological Properties ◽  
Future Research ◽  
Material Strength ◽  
Porous Scaffolds ◽  
Design Decision ◽  
Bone Properties ◽  
Target Values

Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way. This study used the QbD system to explore the Quality Target Product Profile and Ideal Quality Attributes of additively manufactured titanium porous scaffolds for bone regeneration with a biomimetic approach. For this purpose, a total of 807 experimental results extracted from 50 different studies were benchmarked against proposed target values based on bone properties, governmental regulations, and scientific research relevant to bone implants. The scaffold properties such as unit cell geometry, pore size, porosity, compressive strength, and fatigue strength were studied. The results of this study may help future research to effectively direct the design process under the QbD system.

MgAl layered double hydroxide/chitosan porous scaffolds loaded with PFTα to promote bone regeneration

Nanoscale ◽  
2017 ◽  
Vol 9 (20) ◽  
pp. 6765-6776 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Qin-Fei Ke ◽  
You-Shui Gao ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Layered Double Hydroxide ◽  
Porous Scaffolds ◽  
Double Hydroxide

scholarly journals Influence of Parathyroid Hormone-Loaded PLGA Nanoparticles in Porous Scaffolds for Bone Regeneration

2015 ◽  
Vol 16 (9) ◽  
pp. 20492-20510 ◽  
Author(s):  
Piergiorgio Gentile ◽  
Vijay Nandagiri ◽  
Ritesh Pabari ◽  
Jacqueline Daly ◽  
Chiara Tonda-Turo ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Regeneration ◽  
Plga Nanoparticles ◽  
Porous Scaffolds

Development of HA-PLGA Scaffold Encapsulating Intact BMP-2 Using Solid Freeform Fabrication Technology

2011 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Jong Young Kim ◽  
Kyung Shin Kang ◽  
Jung Kyu Park ◽  
Sei Kwang Hahn ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Porous Scaffold ◽  
Solid Freeform Fabrication ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Prolonged Release ◽  
Cellular Activity ◽  
Freeform Fabrication

Tissue engineering is an interdisciplinary field that focuses on restoring and repairing tissues or organs. Cells, scaffolds, and biomolecules are recognized as three main components of tissue engineering. Solid freeform fabrication (SFF) technology is required to fabricate three-dimensional (3D) porous scaffolds to provide a 3D environment for cellular activity. SFF technology is especially advantageous for achieving a fully interconnected, porous scaffold. Bone morphogenic protein-2 (BMP-2), an important biomolecule, is widely used in bone tissue engineering to enhance bone regeneration activity. However, methods for the direct incorporation of intact BMP-2 within 3D scaffolds are rare. In this work, 3D porous scaffolds with poly(lactic-co-glycolic acid) chemically grafted hyaluronic acid (HA-PLGA), in which intact BMP-2 was directly encapsulated, were successfully fabricated using SFF technology. BMP-2 was previously protected by poly(ethylene glycol) (PEG), and the BMP-2/PEG complex was incorporated in HA-PLGA using an organic solvent. The HAPLGA/PEG/BMP-2 mixture was dissolved in chloroform and deposited via a multi-head deposition system (MHDS), one type of SFF technology, to fabricate a scaffold for tissue engineering. An additional air blower system and suction were installed in the MHDS for the solvent-based fabrication method. An in vitro evaluation of BMP-2 release was conducted, and prolonged release of intact BMP-2, for up to 28 days, was confirmed. After confirmation of advanced proliferation of pre osteoblasts, a superior differentiation effect of the HA-PLGA/PEG/BMP-2 scaffold was validated by measuring high expression levels of bone-specific markers, such as alkaline phosphatase (ALP) and osteocalcin (OC). We show that our solvent-based fabrication is a non-toxic method for restoring cellular activity. Moreover, the HAPLGA/PEG/BMP-2 scaffold was effective for bone regeneration.

scholarly journals Polycaprolactone / bioactive glass hybrid scaffolds for bone regeneration

2018 ◽  
Vol 4 (1) ◽  
pp. 108-122 ◽  
Author(s):  
Cédric Bossard ◽  
Henri Granel ◽  
Yohann Wittrant ◽  
Édouard Jallot ◽  
Jonathan Lao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Degradation Rate ◽  
Sol Gel ◽  
Bone Substitutes ◽  
Porous Scaffolds ◽  
Apatite Formation ◽  
Bovine Bone ◽  
Bioactive Glasses ◽  
Hybrid Scaffolds

Abstract Bioactive glasses (BG) bond to bone and stimulate bone regeneration, but they are brittle. Inorganicorganic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of BG with the toughness of polymers. Hybrids comprised of polycaprolactone (PCL) and SiO2-CaO BG were produced by sol-gel chemistry and processed into porous scaffolds with controlled pore and interconnection sizes. The obtained scaffolds are highly flexible, meaning that PCL effectively introduces toughness. Apatite formation is observed within 24 hours of immersion in simulated body fluid (SBF) and is not limited to the surface as the entire hybrid progressively changes into bone-like minerals. The degradation rate is suitable for bone regeneration with a 13.2% weight loss after 8 weeks of immersion. Primary osteoblasts cultured in scaffolds demonstrate that the samples are not cytotoxic and provide good cell adhesion. The in vivo study confirms the bioactivity, biocompatibility and suitable degradation rate of the hybrid. A physiological bone made of trabeculae and bone marrow regenerates. The structure and kinetic of bone regeneration was similar to the implanted commercial standard based on bovine bone, demonstrating that this new synthetic PCL-BG hybrid could perform as well as animal-derived bone substitutes.

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