scholarly journals Exploring Macroporosity of Additively Manufactured Titanium Metamaterials for Bone Regeneration with Quality by Design: A Systematic Literature Review

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4794
Author(s):  
Daniel Martinez-Marquez ◽  
Ylva Delmar ◽  
Shoujin Sun ◽  
Rodney A. Stewart
Keyword(s):  
Bone Regeneration ◽  
Design Process ◽  
Quality By Design ◽  
Biological Properties ◽  
Future Research ◽  
Material Strength ◽  
Porous Scaffolds ◽  
Design Decision ◽  
Bone Properties ◽  
Target Values

Additive manufacturing facilitates the design of porous metal implants with detailed internal architecture. A rationally designed porous structure can provide to biocompatible titanium alloys biomimetic mechanical and biological properties for bone regeneration. However, increased porosity results in decreased material strength. The porosity and pore sizes that are ideal for porous implants are still controversial in the literature, complicating the justification of a design decision. Recently, metallic porous biomaterials have been proposed for load-bearing applications beyond surface coatings. This recent science lacks standards, but the Quality by Design (QbD) system can assist the design process in a systematic way. This study used the QbD system to explore the Quality Target Product Profile and Ideal Quality Attributes of additively manufactured titanium porous scaffolds for bone regeneration with a biomimetic approach. For this purpose, a total of 807 experimental results extracted from 50 different studies were benchmarked against proposed target values based on bone properties, governmental regulations, and scientific research relevant to bone implants. The scaffold properties such as unit cell geometry, pore size, porosity, compressive strength, and fatigue strength were studied. The results of this study may help future research to effectively direct the design process under the QbD system.

Value-Driven Design Process: A Systematic Decision-Making Framework Considering Different Attribute Preferences From Multiple Stakeholders

2016 ◽  
Vol 139 (2) ◽  
Author(s):  
Jun Zhuang ◽  
Ming Hu ◽  
Fatemeh Mousapour
Keyword(s):  
Decision Making ◽  
Design Process ◽  
Architectural Design ◽  
Sustainable Design ◽  
Building Blocks ◽  
Problem Definition ◽  
Future Research ◽  
Decision Making Process ◽  
Design Decision ◽  
Multiple Stakeholders

In general, architectural design is a loosely structured, open-ended activity that includes problem definition, representation, performance evaluation, and decision making. A number of approaches have been proposed in the literature to organize, guide, and facilitate the design process. The main objective of this paper is to seek a logical and rigorous means to aid in developing an optimized design that is acceptable to the customer or user of the product. The convention design approaches heavily involve decision making, which is integral to the architectural design process and is an important element in nearly all phases of design. There is a need to reframe the decision-making process to transform and improve the design process in order for finial building to achieve the performance goals. The first step in making an effective design decision is to understand the stakeholders' and team players' (architect, engineer, client, and consultant) different preferences based on their needs, experiences, and expectations of the project. In this paper, we first provide an overview about conventional decision-making method and process, identify the existing attributes that contribute to decision making in design, and outline the obstacles present in making optimized sustainable design decisions due to the uncertainty of different stakeholders' preferences. Then, we present one case study to identify and compare different preferences among engineering students, practicing architects, and the general public, and we analyze how the three groups attribute different weight to the major design attributes. This paper provides some novel insights into a value-driven sustainable design process, and it will be one of the building blocks for creating a framework to integrate game theory into the design decision-making process, considering multiple stakeholders' perspectives and preferences for building attributes as future research tasks.

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

2014 ◽  
Vol 3 (6) ◽  
Author(s):  
Azizeh-Mitra Yousefi ◽  
Hassane Oudadesse ◽  
Rosa Akbarzadeh ◽  
Eric Wers ◽  
Anita Lucas-Girot
Keyword(s):  
Bone Regeneration ◽  
Chemical Structure ◽  
Bone Repair ◽  
Biological Properties ◽  
Porous Scaffolds ◽  
Main Body ◽  
Bioactive Glasses ◽  
Future Directions ◽  
Recent Developments ◽  
Synthetic Hydroxyapatite

AbstractCritical-sized bone defects have, in many cases, posed challenges to the current gold standard treatments. Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics; however, the difficulty in producing porous scaffolds made of bioactive glasses has limited their extensive use in bone regeneration. On the other hand, calcium phosphate ceramics such as synthetic hydroxyapatite and tricalcium phosphate are widely used in the clinic, but they stimulate less bone regeneration. This paper gives an overview of the recent developments in the field of bioactive nanoparticles, with a focus on nanohydroxyapatite and bioactive glasses for bone repair and regeneration. First, a brief overview of the chemical structure and common methods used to produce synthetic nanohydroxyapatite and bioactive glasses has been presented. The main body of the paper covers the physical and biological properties of these biomaterials, as well as their composites with biodegradable polymers used in bone regeneration. A summary of existing challenges and some recommendations for future directions have been brought in the concluding section of this paper.

A Conceptual Model of Agreement Options for Value-based Group Decision on Value Management

2014 ◽  
Vol 70 (7) ◽  
Author(s):  
Christiono Utomo ◽  
Rosli Mohamad Zin ◽  
Rozana Zakaria ◽  
Yani Rahmawati
Keyword(s):  
Conceptual Model ◽  
Decision Maker ◽  
Design Process ◽  
Group Decision ◽  
Optimal Solution ◽  
Decision Makers ◽  
Future Research ◽  
Value Management ◽  
Design Decision ◽  
Wide Range

A group decision must be made when a design process is conducted by more than one person. In this situation, negotiation plays an important role in many design decision. Value Management (VM) is one of design decision methodology in construction. By involving multi disciplines, collaboration and teamwork, negotiation becomes an important role on VM using a value-based group design decision. This paper provides an approach to develop a conceptual model of agreement options for group decision in building wall system selection using value criteria which are function and cost. The characteristic of value criteria has not been applied on previous researches. Existing models which are commonly accepted are optimization-based models, for example aggregation methods, but these are not able to solve the problem of value criteria on VM. Group decision needs to identify the goals that can be optimized and those that can be compromised in order to reach an agreement among decision makers. Agreement options are determined by identifying the potential decision makers followed by determining the optimal solution for each sub-group. Five stages are conducted to identify and determine agreement options as a conceptual model which are determining the weighting factor of criteria for each decision maker; grading alternative for each evaluation criteria; scoring every alternative for every decision maker; determining the optimal solution; and determining the fitness factor of an alternative solution The agreement option model is facilitated to better design decision. The model developed in this research can be used for any development research on group decision and negotiation in design process within the construction industry. Future research in the application of this methodology in many field of decision will build a wide range of knowledge to solve the theoretical and practical gap between automated design and automated negotiation.  

Roles of externalisation activities in the design process

2016 ◽  
Vol 11 (1) ◽  
pp. 34
Author(s):  
Maral Babapour Chafi
Keyword(s):  
Design Process ◽  
Design Research ◽  
Research Literature ◽  
Physical Models ◽  
Future Research ◽  
Knowledge Gaps ◽  
Design Processes ◽  
Digital Modelling

Designers engage in various activities, dealing with different materials and media to externalise and represent their form ideas. This paper presents a review of design research literature regarding externalisation activities in design process: sketching, building physical models and digital modelling. The aim has been to review research on the roles of media and representations in design processes, and highlight knowledge gaps and questions for future research.

scholarly journals Bioresorbable Magnesium-Based Alloys as Novel Biomaterials in Oral Bone Regeneration: General Review and Clinical Perspectives

2021 ◽  
Vol 10 (9) ◽  
pp. 1842
Author(s):  
Valentin Herber ◽  
Begüm Okutan ◽  
Georgios Antonoglou ◽  
Nicole G. Sommer ◽  
Michael Payer
Keyword(s):  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Modulus Of Elasticity ◽  
Bone Repair ◽  
Clinical Results ◽  
Porous Scaffolds ◽  
General Review ◽  
Synthetic Materials ◽  
Bone Preservation

Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration.

scholarly journals Integrating Theory in Co-design: An Abductive Approach

2021 ◽  
Vol 29 (1) ◽  
pp. 66-77
Author(s):  
Erin Hurley ◽  
Timo Dietrich ◽  
Sharyn Rundle-Thiele
Keyword(s):  
Social Cognitive Theory ◽  
Design Process ◽  
Social Marketing ◽  
Social Cognitive ◽  
Cognitive Theory ◽  
Expert Knowledge ◽  
Future Research ◽  
Abductive Inference ◽  
Design Framework ◽  
Research Recommendations

Co-design empowers people, giving them a voice in social marketing program design; however, approaches have mostly excluded expert knowledge. An abductive approach to co-design allows for inclusion of expert knowledge, providing theoretical guidance while simultaneously investigating user views and ideas extending understanding beyond known effective approaches. We use the seven-step co-design framework and outline how an abductive inference can be applied to co-design. Social cognitive theory constructs were integrated into the seven-step co-design process. The abductive approach to co-design was tested in two co-design sessions involving 40 participants. Findings demonstrate that theory can be successfully integrated into the seven-step co-design process through utilization of theory-mapped activity cards. This article provides guidance on how theory can be incorporated into ideation and insight generation. Limitations and future research recommendations are provided.

scholarly journals Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

2021 ◽  
Vol 22 (12) ◽  
pp. 6222
Author(s):  
Kacper Szewczyk ◽  
Aleksandra Chojnacka ◽  
Magdalena Górnicka
Keyword(s):  
Vitamin E ◽  
Metabolic Disorders ◽  
Tissue Concentration ◽  
Biological Properties ◽  
Biological Role ◽  
Future Research ◽  
The Past ◽  
The Subject ◽  
The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

scholarly journals Energy Rating of Buildings to Promote Energy-Conscious Design in Israel

Buildings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 59
Author(s):  
Abraham Yezioro ◽  
Isaac Guedi Capeluto
Keyword(s):  
Design Process ◽  
Architectural Design ◽  
Residential Building ◽  
Green Building ◽  
Energy Performance ◽  
Basic Unit ◽  
Design Stage ◽  
Design Decision ◽  
Rating Systems ◽  
New Buildings

Improving the energy efficiency of existing and new buildings is an important step towards achieving more sustainable environments. There are various methods for grading buildings that are required according to regulations in different places for green building certification. However, in new buildings, these rating systems are usually implemented at late design stages due to their complexity and lack of integration in the architectural design process, thus limiting the available options for improving their performance. In this paper, the model ENERGYui used for design and rating buildings in Israel is presented. One of its main advantages is that it can be used at any design stage, including the early ones. It requires information that is available at each stage only, as the additional necessary information is supplemented by the model. In this way, architects can design buildings in a way where they are aware of each design decision and its impact on their energy performance, while testing different design directions. ENERGYui rates the energy performance of each basic unit, as well as the entire building. The use of the model is demonstrated in two different scenarios: an office building in which basic architectural features such as form and orientation are tested from the very beginning, and a residential building in which the intervention focuses on its envelope, highlighting the possibilities of improving their design during the whole design process.

scholarly journals Integrating Value Considerations in the Decision Making for the Design of Biorefineries

2020 ◽  
Vol 26 (6) ◽  
pp. 2927-2955
Author(s):  
Mar Palmeros Parada ◽  
Lotte Asveld ◽  
Patricia Osseweijer ◽  
John Alexander Posada
Keyword(s):  
Decision Making ◽  
Complex Systems ◽  
Research And Development ◽  
Design Process ◽  
Design Decision ◽  
Value Sensitive Design ◽  
Design Practice ◽  
Novel Approach ◽  
Design Alternatives ◽  
Biobased Production

AbstractBiobased production has been promoted as a sustainable alternative to fossil resources. However, controversies over its impact on sustainability highlight societal concerns, value tensions and uncertainties that have not been taken into account during its development. In this work, the consideration of stakeholders’ values in a biorefinery design project is investigated. Value sensitive design (VSD) is a promising approach to the design of technologies with consideration of stakeholders’ values, however, it is not directly applicable for complex systems like biorefineries. Therefore, some elements of VSD, such as the identification of relevant values and their connection to a technology’s features, are brought into biorefinery design practice. Midstream modulation (MM), an approach to promoting the consideration of societal aspects during research and development activities, is applied to promote reflection and value considerations during the design decision making. As result, it is shown that MM interventions during the design process led to new design alternatives in support of stakeholders' values, and allowed to recognize and respond to emerging value tensions within the scope of the project. In this way, the present work shows a novel approach for the technical investigation of VSD, especially for biorefineries. Also, based on this work it is argued that not only reflection, but also flexibility and openness are important for the application of VSD in the context of biorefinery design.

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