Ultrasound assisted production of daunorubicin: Process intensification approach

2014 ◽  
Vol 77 ◽  
pp. 7-12 ◽  
Author(s):  
Hanumant D. Raskar ◽  
Devchand N. Avhad ◽  
Virendra K. Rathod
Keyword(s):  
Process Intensification ◽  
Ultrasound Assisted

scholarly journals Batch and Flow Ultrasound-Assisted Extraction of Grape Stalks: Process Intensification Design up to a Multi-Kilo Scale

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 730
Author(s):  
Giorgio Grillo ◽  
Luisa Boffa ◽  
Salvatore Talarico ◽  
Roberto Solarino ◽  
Arianna Binello ◽  
...  
Keyword(s):  
Extraction Procedure ◽  
Process Intensification ◽  
Process Efficiency ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Total Phenolic ◽  
Hyperbolic Model ◽  
Flow Mode ◽  
Bag Filter ◽  
Ultrasound Assisted ◽  
Grape Stalks

Nowadays, approximately 1 billion kg/y of grape stalks, with a remarkable polyphenols content, are produced worldwide. In this paper, the extraction process intensification of polyphenols in water was achieved under ultrasound-assisted recovery, focusing on kinetics and scaling-up factors. Immersion and cup-horn systems were exploited as acoustic cavitation sources, and the total phenolic content (TPC) was chosen to assess the process efficiency. The kinetics were evaluated by Peleg’s hyperbolic model, and the effect of both the initial feedstock granulometry and ultrasound size-reduction were determined. The results were compared with conventional extraction methods (data analysis by ANOVA). The best polyphenols yield was obtained after 45 min of sonication, giving between 29.71 and 31.89 mg/g (gallic acid equivalents over the dry matter). The extracts were characterized using HPLC-DAD, UPLC-ESI-MS/MS, DPPH• assay (2,2-diphenyl-1-picrylhydrazyl), TEAC assay (Trolox equivalent antioxidant capacity), and proanthocyanidin content determination. The flow-mode extraction procedure of grape stalks (2 kg) was carried out in a 15 L reactor. A semi-industrial decanter unit and a bag-filter were the keys units of the downstream operations. The resulting particle-free solution underwent nanofiltration on a membrane pilot skid, providing a final polyphenols-enriched stream concentrated up to 355.91%, as shown by the antioxidant activity and TPC.

scholarly journals Hydrolysis of agricultural waste to obtain reducing sugars using conventional and ultrasound-assisted technologies

2015 ◽  
Vol 17 (4) ◽  
pp. 816-824
Keyword(s):  
Reducing Sugars ◽  
Agricultural Waste ◽  
Process Intensification ◽  
High Yield ◽  
Influence Of Temperature ◽  
Rice Hulls ◽  
Ultrasound Assisted ◽  
Optimized Conditions ◽  
Hydrolysis Of ◽  
Assisted Technologies

<div> <p>The main objective of this study was to evaluate the hydrolysis of rice hulls to obtain reducing sugars by conventional and ultrasound-assisted acid hydrolysis. For this purpose, the methodology of experimental design was used to evaluating the influence of temperature, moisture content and concentration of phosphoric acid on the yield of reducing sugars. The yields at optimized conditions were of 141.1 and 162.0 g.kg<sup>-1</sup>, for conventional and ultrasound-assisted hydrolysis, respectively. It was possible to obtain high yield using less acid and low temperature, in a manner that ultrasound can be used as a technology for process intensification.&nbsp;</p> </div> <p>&nbsp;</p>

Intensification of enzyme catalysed synthesis of hexyl acetate using sonication

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Ashwini R. Deshmukh ◽  
Virendra K. Rathod
Keyword(s):  
Conventional Method ◽  
Duty Cycle ◽  
Process Intensification ◽  
Agitation Speed ◽  
Molar Ratio ◽  
Hexyl Acetate ◽  
Enzyme Loading ◽  
Ultrasound Assisted ◽  
Fruity Odor

AbstractThis present study focuses on ultrasound assisted process intensification of hexyl acetate synthesis via lipozyme RMIM catalysed transesterification of hexanol with triacetin by using hexane as a solvent. Hexyl acetate, an ester with fruity odor and significant green note is mostly used as flavor and fragrance material in various areas. Effect of various parameters on conversion of hexyl acetate such as molar ratio, enzyme loading, temperature, power, agitation speed and duty cycle was studied systematically. With the molar ratio of 1:1 of hexanol to triacetin with 4% enzyme loading (w/v), at agitation speed of 100 rpm with application of sonication at 60 W power and 70% duty cycle resulted in to 83% conversion at 50°C temperature in 4 h when compared with conventional method which requires 9 h for 68% conversion.

scholarly journals Glucose obtained from rice bran by ultrasound-assisted enzymatic hydrolysis

2015 ◽  
Vol 35 (2) ◽  
pp. 61-66 ◽  
Author(s):  
Raquel Cristine Kuhn ◽  
Marcio Antonio Mazutti ◽  
Edson Luiz Foletto ◽  
Valéria Dal Prá ◽  
Eduardo Zimmermann ◽  
...  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Moisture Content ◽  
Rice Bran ◽  
Enzymatic Reaction ◽  
Process Intensification ◽  
Ultrasound Irradiation ◽  
Enzyme Concentration ◽  
Rate Period ◽  
Ultrasound Assisted ◽  
Hydrolysis Of

<p>In this work ultrasound-assisted solid-state enzymatic hydrolysis of rice bran to obtain fermentable sugars was investigated. For this purpose, process variables such as temperature, enzyme concentration and moisture content were evaluated during the enzymatic hydrolysis with and without ultrasound irradiation. The enzyme used is a blend of amylases derived from genetically modified strains of <em>Trichoderma</em> <em>reesei</em>. Kinetic of the enzymatic hydrolysis of rice bran at the constant-reaction rate period were measured. The best results for the ultrasound-assisted enzymatic hydrolysis was obtained using 3 wt% of enzyme, 60 <sup>o</sup>C and moisture content of 65 wt%, yielding 0.38 g sugar/g rice bran, whereas for the hydrolysis in the absence of ultrasound the highest yield was 0.20 g sugar/g rice bran using 3 wt% of enzyme, 60 <sup>o</sup>C and moisture content of 50 wt%. The use of ultrasound-assisted enzymatic hydrolysis of rice bran was intensified, obtaining around 74% more fermentable sugar than in the absence, showing that the use of ultrasound is a promising technology to be used in enzymatic reaction as an alternative of process intensification. </p>

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