scholarly journals Quantification and statistical significance analysis of group separation in NMR-based metabonomics studies

2011 ◽  
Vol 109 (2) ◽  
pp. 162-170 ◽  
Author(s):  
Aaron M. Goodpaster ◽  
Michael A. Kennedy
2016 ◽  
Vol 30 (13) ◽  
pp. 1650187 ◽  
Author(s):  
Ju Li ◽  
Hui-Jia Li ◽  
He-Jin Mao ◽  
Junhua Chen

The study of community structure is an important problem in a wide range of applications, which can help us understand the real network system deeply. However, due to the existence of random factors and error edges in real networks, how to measure the significance of community structure efficiently is a crucial question. In this paper, we present a novel statistical framework computing the significance of community structure across multiple optimization methods. Different from the universal approaches, we calculate the similarity between a given node and its leader and employ the distribution of link tightness to derive the significance score, instead of a direct comparison to a randomized model. Based on the distribution of community tightness, a new “[Formula: see text]-value” form significance measure is proposed for community structure analysis. Specially, the well-known approaches and their corresponding quality functions are unified to a novel general formulation, which facilitates in providing a detailed comparison across them. To determine the position of leaders and their corresponding followers, an efficient algorithm is proposed based on the spectral theory. Finally, we apply the significance analysis to some famous benchmark networks and the good performance verified the effectiveness and efficiency of our framework.


2010 ◽  
Vol 401 (1) ◽  
pp. 134-143 ◽  
Author(s):  
Aaron M. Goodpaster ◽  
Lindsey E. Romick-Rosendale ◽  
Michael A. Kennedy

2003 ◽  
Vol 19 (13) ◽  
pp. 1628-1635 ◽  
Author(s):  
X. Guo ◽  
H. Qi ◽  
C. M. Verfaillie ◽  
W. Pan

Author(s):  
Serge Dolgikh

AbstractWe present an updated time-adjusted dataset and conclusions at Covid-19 Time Zero + 5 month (04.06.2020). The conclusions of the original analysis reviewed and mostly maintained at this time point. With the data accumulated to date a statistical significance of the BCG immunization correlation hypothesis is evaluated with the conclusion that it has achieved the level of confidence. Several specific cases are discussed with respect to the induced immunity hypothesis.


Author(s):  
N.J. Tao ◽  
J.A. DeRose ◽  
P.I. Oden ◽  
S.M. Lindsay

Clemmer and Beebe have pointed out that surface structures on graphite substrates can be misinterpreted as biopolymer images in STM experiments. We have been using electrochemical methods to react DNA fragments onto gold electrodes for STM and AFM imaging. The adsorbates produced in this way are only homogeneous in special circumstances. Searching an inhomogeneous substrate for ‘desired’ images limits the value of the data. Here, we report on a reversible method for imaging adsorbates. The molecules can be lifted onto and off the substrate during imaging. This leaves no doubt about the validity or statistical significance of the images. Furthermore, environmental effects (such as changes in electrolyte or surface charge) can be investigated easily.


2003 ◽  
Vol 73 (6) ◽  
pp. 439-445 ◽  
Author(s):  
Navia ◽  
Ortega ◽  
Requejo ◽  
Perea ◽  
López-Sobaler ◽  
...  

A study was conducted on the influence of maternal education level on food consumption, energy and nutrient intake, and dietary adequacy in 110 pre-school children from Madrid, Spain. With increasing maternal education, children consumed more sugar (p < 0.05), fruit (p < 0.05), and fish (p < 0.05). Snacking was more frequent with decreasing maternal education (p < 0.05). Though statistical significance was not reached, the consumption of pre-cooked foods was greater among children of mothers educated to a higher level, a phenomenon probably related to the work situation of these women. With respect to dietary composition, no significant differences were found between groups for macronutrient, fiber and energy intakes, except for energy supplied by polyunsaturated fatty acids (PUFA), which was greater in the children of less educated women (p < 0.01). This is probably due to their greater consumption of sunflower seed oil. The diets of children belonging to well-educated mothers came closer to meeting the recommended intakes for folate, vitamin C, and iodine. It would seem that maternal educational level influences the food habits of children. Mothers with less education may require special advice in this area.


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