Menopause as determinant of fatty liver index at population level

AbstractFatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.

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AB0264 Fatty Liver Index Predicts Glucose Metabolism Disturbance in Inflammatory Arthritis Patients

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.5457 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 990.1-990

Author(s):

C. Tripolino ◽

F. Ursini ◽

C. Bruno ◽

K. Nicolosi ◽

S. Naty ◽

...

Keyword(s):

Glucose Metabolism ◽

Fatty Liver ◽

Inflammatory Arthritis ◽

Liver Index ◽

Fatty Liver Index

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A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study

PLoS ONE ◽

10.1371/journal.pone.0143560 ◽

2015 ◽

Vol 10 (11) ◽

pp. e0143560 ◽

Cited By ~ 22

Author(s):

Ji Hye Huh ◽

Song Vogue Ahn ◽

Sang Baek Koh ◽

Eunhee Choi ◽

Jang Young Kim ◽

...

Keyword(s):

Prospective Study ◽

Fatty Liver ◽

Incident Hypertension ◽

Liver Index ◽

Fatty Liver Index ◽

A Prospective Study

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Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese

Medicine ◽

10.1097/md.0000000000001682 ◽

2015 ◽

Vol 94 (40) ◽

pp. e1682 ◽

Cited By ~ 35

Author(s):

Xiaolin Huang ◽

Min Xu ◽

Ying Chen ◽

Kui Peng ◽

Ya Huang ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Middle Aged ◽

Nonalcoholic Fatty Liver ◽

Liver Index ◽

Fatty Liver Index ◽

Elderly Chinese

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Elevated fatty liver index as a risk factor for all-cause mortality in HIV-HCV co-infected patients

European Journal of Public Health ◽

10.1093/eurpub/ckz186.213 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

T Barré ◽

C Protopopescu ◽

F Bani-Sadr ◽

L Piroth ◽

P Sogni ◽

...

Keyword(s):

Risk Factor ◽

Fatty Liver ◽

Clinical Signs ◽

People Living With Hiv ◽

Metabolic Complications ◽

Non Invasive ◽

Liver Index ◽

Fatty Liver Index ◽

All Cause Mortality ◽

History Of

Abstract Background Thanks to innovation in treatment, people living with HIV and/or HCV now live longer but are growingly facing non-communicable disease burden. HIV-HCV co-infected patients are at high risk of metabolic complications and liver-related events, which are both associated with hepatic steatosis and its progressive form, non-alcoholic steatohepatitis (NASH), a known risk factor for mortality. The fatty liver index (FLI), a non-invasive steatosis biomarker, has recently drawn attention for its clinical prognostic value, but has never been applied to HIV-HCV co-infected patients. We aimed at testing whether elevated FLI (≥60) was associated with all-cause mortality in co-infected patients. Methods Our study is based on data from ANRS CO13 HEPAVIH, a French national prospective cohort of HIV-HCV co-infected patients. Socio-behavioral and clinical data from patients clinically followed-up were used in the analysis. Using a Cox proportional hazards model for mortality from all causes (983 patients; 4,432 visits), we computed hazard ratios associated with risk factors and confounders. Results After multiple adjustment, individuals with FLI≥60 had almost double the risk of all-cause mortality (adjusted hazard ratio [95% confidence interval]: 1.91 [1.17-3.12], p = 0.009), independently of HCV cure (0.21 [0.07-0.61], p = 0.004), advanced fibrosis (1.77 [1.00-3.14], p = 0.05), history of hepatocellular carcinoma and/or liver transplantation (7.74 [3.82-15.69], p < 10-3), history of indirect clinical signs of cirrhosis (2.80 [1.22-6.41], p = 0.015), and HIV CDC clinical stage C (2.88 [1.74-4.79], p < 10-3). Conclusions An elevated fatty liver index is a risk factor for all-cause mortality in HIV-HCV co-infected patients independently of liver fibrosis and HCV cure. In the present era of nearly 100% HCV cure rates, these findings encourage the more systematic use of non-invasive steatosis biomarkers to help identify co-infected patients with higher mortality risk. Key messages A FLI≥60 is strongly associated with mortality in HIV-HCV co-infected patients. FLI could be calculated routinely to identify most at-risk patients.

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Bile Acid and Fibroblast Growth Factor 19 Regulation in Obese Diabetics, and Non-Alcoholic Fatty Liver Disease after Sleeve Gastrectomy

Journal of Clinical Medicine ◽

10.3390/jcm8060815 ◽

2019 ◽

Vol 8 (6) ◽

pp. 815 ◽

Cited By ~ 18

Author(s):

Hsien-Hao Huang ◽

Wei-Jei Lee ◽

Shu-Chun Chen ◽

Tung-Fang Chen ◽

Shou-Dong Lee ◽

...

Keyword(s):

Bile Acid ◽

Fatty Liver ◽

Bile Acids ◽

Fatty Liver Disease ◽

Total Bile Acid ◽

Alcoholic Fatty Liver ◽

Liver Index ◽

Fatty Liver Index ◽

Total Bile Acids ◽

Alcoholic Fatty Liver Disease

Background: Sleeve gastrectomy (SG) is an effective treatment for obesity and type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD); however, the mechanism is not completely understood. Bile acids and fibroblast growth factors (FGFs) are involved in the regulation of energy metabolism. Methods: We investigated the roles of total bile acid and FGF 19 in T2DM remission and NAFLD improvement in obese subjects undergoing SG. A total of 18 patients with obesity and T2DM undergoing laparoscopic SG were enrolled in this study. Serial plasma total bile acid and FGF 19 levels were measured, while the fatty liver index was calculated before and after surgery. Results: The FGF 19 level significantly increased, and the total bile acid level and fatty liver index decreased 1 year after surgery. The complete T2DM remission rate was 66.7% one year after surgery; the complete remitters had significantly lower FGF 19 levels and higher insulin levels than the non-complete remitters. The complete remitters also had significantly decreased total bile acid levels and increased FGF 19 levels 1 year after surgery compared with those before surgery. The fatty improvers had significantly decreased total bile acid levels and increased FGF 19 levels 1 year after surgery compared with those before surgery. Conclusion: The total bile acids level and fatty liver index decreased, and the FGF 19 levels increased 1 year after SG. Both T2DM complete remitters and NAFLD improvers showed significantly decreased total bile acid levels and increased FGF 19 levels 1 year after SG. Plasma total bile acids and FGF 19 might have roles in T2DM remission and NAFLD improvement. Low preoperative FGF 19 levels might be a predictor for NAFLD improvement after SG.

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