Structure behaviors of hemoglobin in PEG 6000/Tween 80/Span 80/H2O niosome system

Hiperurisemia adalah keadaan dimana terjadi peningkatan kadar asam urat dalam darah diatas normal. Tanaman kenikir (Cosmos caudatus) merupakan tanaman yang banyak dijumpai di lingkungan sekitar, serta tanaman yang sudah tidak asing lagi dan telah banyak dikonsumsi sebagai sayuran. Salah satu kandungan dalam kenikir adalah senyawa golongan flavonoid. Pada penelitian ini mikroemulsi ekstrak kenikir digunakan untuk menurunkan kadar asam urat pada tikus yang diinduksi hati ayam. Mikroemulsi dibuat dengan menggunakan virgin coconut oil (VCO) sebagai fase minyak, Tween 80 dan Span 80 sebagai surfaktan dan gliserin sebagai kosurfaktan. Penelitian menggunakan 15 ekor tikus putih jantan galur wistar yang diinduksi jus hati ayam. Tikus dibagi menjadi 3 kelompok, yaitu kelompok kontrol negatif mikroemulsi placebo, kontrol positif mikroemulsi Allopurinol 3,6 mg/200 g BB tikus, serta kelompok perlakuan mikroemulsi daun kenikir 10 mg/200 g BB tikus yang diberikan secara peroral. Pengukuran kadar asam urat dilakukan pada hari ke-0 (kadar awal), hari ke-7 (kadar setelah induksi) dan hari ke-13(kadar setelah perlakuan). Persen penurunan kadar asam urat dalam darah dianalisis secara statistika dengan taraf kepercayaan 95%. Hasil uji statistika menyatakan ada perbedaan antara kelompok kontrol negatif dan positif dengan kelompok perlakuan mikroemulsi daun kenikir memiliki nilai signifikansi 0,000. Sehingga mikroemulsi daun kenikir dapat menurunkan kadar urisemia tikus yang diinduksi ekstrak hati ayam namun memiliki kemampuan yang tidak sebaik mikroemulsi allopurinol. Kata Kunci : Mikroemulsi, Kenikir (Cosmos Caudatus), Hiperurisemia, Ekstrak Hati Ayam, Allopurinol.

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Effect of water content on structural and phase behavior of water-in-oil (n-decane) microemulsion system stabilized by mixed nonionic surfactants SPAN 80/TWEEN 80

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2017.01.020 ◽

2017 ◽

Vol 518 ◽

pp. 273-282 ◽

Cited By ~ 22

Author(s):

A.S. Koneva ◽

E.A. Safonova ◽

P.S. Kondrakhina ◽

M.A. Vovk ◽

A.A. Lezov ◽

...

Keyword(s):

Phase Behavior ◽

Water Content ◽

Nonionic Surfactants ◽

Tween 80 ◽

Microemulsion System ◽

Effect Of Water ◽

Span 80

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Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories

Current Issues in Pharmacy and Medical Sciences ◽

10.2478/cipms-2014-0012 ◽

2014 ◽

Vol 27 (1) ◽

pp. 46-50 ◽

Cited By ~ 2

Author(s):

Regina Kasperek ◽

Krzysztof Galczynski ◽

Magdalena Nalesniak ◽

Karol Iwaniak ◽

Ewa Poleszak

Keyword(s):

Cocoa Butter ◽

Acidic Medium ◽

Tween 80 ◽

Rectal Administration ◽

Dissolution Medium ◽

Release Process ◽

Vaginal Administration ◽

Release Study ◽

Span 80 ◽

Pharmacopoeial Requirements

Abstract Suppositories with cocoa butter containing dehydroepiandrosterone (DHEA) without and with the addition of Span 80 and Tween 80 as surfactants with low and high HLB values were prepared. The physical properties and the drug content of all prepared suppositories were in accordance with the pharmacopoeial requirements. The release study tests in three dissolution media such as water, lactic acid solution at pH 4.2 and phosphate buffer at pH 7.4 were carried out. In acidic and alkalic media only about 10% and 27% of DHEA were released, respectively. The addition of Span 80 to the suppository mass did not improve the release process, but the addition of Tween 80 caused the increase in the amount of DHEA released in the acidic medium to about 35%. The data showed that rectal administration of suppositories with DHEA based on cocoa butter caused about 30% availability and after vaginal administration, only topical activity can be expected. By the addition of Tween 80 to the suppository mass availability of DHEA of about 35% from vaginal suppositories can be achieved.

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Novel solid–solid phase change materials with biodegradable trihydroxy surfactants for thermal energy storage

RSC Advances ◽

10.1039/c5ra11842e ◽

2015 ◽

Vol 5 (84) ◽

pp. 68881-68889 ◽

Cited By ~ 39

Author(s):

Xiaowei Fu ◽

Weibo Kong ◽

Yanyan Zhang ◽

Liang Jiang ◽

Jiliang Wang ◽

...

Keyword(s):

Energy Storage ◽

Phase Change ◽

Thermal Energy ◽

Thermal Energy Storage ◽

Phase Change Materials ◽

Solid Phase ◽

Tween 80 ◽

Span 80 ◽

First Time ◽

Crosslinking Agents

Polyurethane polymers were synthesized as novel solid–solid phase change materials (SSPCMs) by bulk polyaddition in the absence of organic solvents using Span 80 and Tween 80 as crosslinking agents for the first time.

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Formulasi dan Evaluasi Sediaan Anti Aging dari Ekstrak Tumbuhan

Farmasetika.com (Online) ◽

10.24198/farmasetika.v4i4.23068 ◽

2019 ◽

Vol 4 (4) ◽

Author(s):

Nadia Fauziah Rahmadiani ◽

Aliya Nur Hasanah

Keyword(s):

Tween 80 ◽

Span 80

Tumbuh-tumbuhan yang berasal dari Indonesia memiliki banyak potensi sebagai bahan dasar produk kosmetika seperti produk antiaging. Sediaan antiaging adalah produk yang bermanfaat untuk menghambat proses kerusakan akibat bertambahnya usia pada kulit. Pengembangan dari formula berbagai sediaan anti aging yang berasal dari ekstrak tumbuhan telah banyak dilakukan, setiap formula pada jenis sediaan yang berbeda dievaluasi untuk mendapat formula terbaik yang memiliki karakteristik yang paling stabil dalam waktu penyimpanan tertentu. Oleh karena itu, pada review artikel ini, berbagai formulasi dan evaluasi pada sediaan krim, gel dan masker peel off antiaging dari ekstrak tumbuhan dikaji lebih lanjut untuk mendapatkan formula paling stabil dengan menggunakan 9 jurnal untuk membandingkan hasil formulasi dan evaluasi dan 27 pustaka sebagai kajian teori. Hasil review menunjukan formula terbaik adalah formula krim yang menggunakan tween 80 dan span 80 dengan konsentrasi 5,11gr dan 0,25gr, formula masker peel off yang mengandung PVA 12% dan HPMC 2% dan formula gel yang menggunakan Na CMC 2% . Kata Kunci : Antiaging, Masker peel-off, krim, gel

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THERAPEUTIC MICROEMULSION OF CURCUMIN FOR THE MANAGEMENT OF OSTEOARTHRITIS

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5-s.1989 ◽

2018 ◽

Vol 8 (5-s) ◽

pp. 341-347

Author(s):

Shreyasi Sharma ◽

Eisha Ganju ◽

Neeraj Upmanyu ◽

Prabhat Jain

Keyword(s):

Oleic Acid ◽

Zeta Potential ◽

Antioxidant Activities ◽

In Vitro Release ◽

Tween 80 ◽

Drug Content ◽

In Vitro Diffusion ◽

Span 80 ◽

Microemulsion Gel

Curcumin (diferuloylmethane) is a natural polyphenolic compound with potent anti-inflammatory, anticancer and antioxidant activities. However, its bioavailability is low as it is poorly absorbed in the gastrointestinal tract. Microemulsions offer the potential to improve the solubility and bioavailability of bioactive compounds; the present work investigated the topical delivery potential of microemulsion gel loaded with curcumas. Curcumin microemulsion was prepared by spontaneous emulsification method using oil (Oleic acid), surfactant:cosurfactant (Smix) (Ethanol and Tween 80, Span 80 and n Butanol) and water. The optimized formulations of microemulsions were subjected to thermodynamic stability tests. After stability study, stable formulation was characterized for droplet size, pH determination, centrifugation, % drug content in microemulsion, zeta potential and vesicle size measurement and then microemulsion gel were prepared and characterized for spreadability, measurement of viscosity, drug content, In-vitro diffusion, in-vitro release data. Tween 80, Span 80 was selected as surfactant, ethanol, n Butanol as co surfactant and Oleic acid as oil component based on solubility study. The optimized formulation contained Curcumin (10 mg). The in vitro drug release from curcumin microemulsion gel was found to be considerably higher in comparison to that of the pure drug. The in-vitro diffusion of microemulsion gel was significantly good. Based on this study, it can be concluded the solubility and permeability of curcumin can be increased by formulating into microemulsion gel. Keyword: Curcumin, Microemulsion, In-vitro diffusion, Spreadability, Zeta potential, Stability, span 40

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Effect of Surfactant Addition on The Physico-Chemical Properties and Stability of Virgin Coconut Oil Nanoemulsions

Buletin Palma ◽

10.21082/bp.v22n1.2021.31-42 ◽

2021 ◽

Vol 22 (1) ◽

pp. 31

Author(s):

Linda Trivana ◽

Nugraha E. Suyatma ◽

Dase Hunaefi ◽

S. Joni Munarso

Keyword(s):

Chemical Properties ◽

Coconut Oil ◽

Tween 80 ◽

Chemical Characteristic ◽

Human Consumption ◽

Virgin Coconut Oil ◽

Tem Analysis ◽

Physico Chemical ◽

Span 80 ◽

The Stability

<p>Virgin coconut oil (VCO) is high quality coconut oil and categorized as the healthiest oil and functional foods. Based on these benefits, the development of a VCO in emulsion product might increase the human consumption of coconut oil because consumers dislike the only taste of pure VCO. The aim of this study was to develop the water compatible form of VCO through nano-emulsification. The effect of different types and amounts of surfactants (Tween 80 and Span 80) on the physio-chemical characteristic of emulsion containing VCO was investigated. VCO based emulsions were prepared with the aid of Ultra-Turrax homogenizer. Emulsions were developed by adding and mixing VCO with surfactants. The ratio of Tween 80 and Span 80 used were 0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0. The droplet size of nanoemulsions consisting of Tween 80:Span 80 (0:10, 2.5:7.5, 5:5, 7.5:2.5, and 10:0) were 1.343, 0.606, 0.829, 1.439, and 2.506µm, respectively. Based on the TEM analysis and polydispersity index (PDI) >0.5 showed the oil droplets are in not uniform shape, indicating a unstable emulsion. VCO emulsion with ratio Tween 80:Span 80 (0:10) obtained a homogeneous emulsion (stable) compare than that of others and w/o type emulsion. The stability of emulsion is evaluated by turbidity measurement using UV-VIS spectrophotometer with wavelength 502 nm. A combination of treatments (ambient condition, thermal treatmeant (40°C)), and centrifuge) of VCO emulsion has resulted on thermal treat, the turbidity measured from the emulsion was higher than the other emulsion, reflecting the presence of the smaller droplets in this emulsion.</p>

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