Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. and conjugated epirubicin: targeted drug delivery for treatment of breast cancer

Green synthesis of AuNPs using extract ofLimonia acidissimaL. as a reducing agent. Epirubicin was successfully loaded on folic acid–AuNPs. This formulation revealed better site specific delivery of epirubicin to MCF-7 cells.

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Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽

10.3390/polym13010059 ◽

2020 ◽

Vol 13 (1) ◽

pp. 59

Author(s):

Abeer M. Beagan ◽

Ahlam A. Alghamdi ◽

Shatha S. Lahmadi ◽

Majed A. Halwani ◽

Mohammed S. Almeataq ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Folic Acid ◽

Drug Delivery System ◽

Targeted Drug Delivery ◽

Ph Responsive ◽

Ethyl Methacrylate ◽

Mesoporous Nanoparticles ◽

Targeted Drug ◽

Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111382 ◽

2021 ◽

Vol 197 ◽

pp. 111382

Author(s):

Priyatosh Sarkar ◽

Santanu Ghosh ◽

Kishor Sarkar

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Folic Acid ◽

Stearic Acid ◽

Triple Negative Breast Cancer ◽

Targeted Drug Delivery ◽

Triple Negative ◽

Carbon Dot ◽

Targeted Drug

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Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.08.036 ◽

2020 ◽

Vol 164 ◽

pp. 2073-2084 ◽

Cited By ~ 2

Author(s):

Arokia Vijaya Anand Mariadoss ◽

Kandasamy Saravanakumar ◽

Anbazhagan Sathiyaseelan ◽

Karthikkumar Venkatachalam ◽

Myeong-Hyeon Wang

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Folic Acid ◽

Cancer Therapy ◽

Copper Oxide ◽

Targeted Drug Delivery ◽

Copper Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Breast Cancer Therapy ◽

Targeted Drug

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Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520620666200310091026 ◽

2020 ◽

Vol 20 (10) ◽

pp. 1233-1240

Author(s):

Maryam Parsian ◽

Pelin Mutlu ◽

Serap Yalcin ◽

Ufuk Gunduz

Keyword(s):

Breast Cancer ◽

Magnetic Field ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Targeted Drug Delivery ◽

Targeted Drug ◽

Drug Free ◽

The Magnetic Field ◽

Mcf 7

Background: Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic moieties, magnetic nanoparticles are widely studied for their applications in medicine. Objective: Gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles (Gem-PHB-MNPs) were synthesized and characterized for the treatment of breast cancer by the targeted drug delivery method. Methods: The characterization of nanoparticles was confirmed by FTIR, XPS, TEM, and spectrophotometric analyses. The cytotoxicities of drug-free nanoparticles and Gemcitabine loaded nanoparticles were determined with cell proliferation assay using SKBR-3 and MCF-7 breast cancer cell lines. Result: The release of Gemcitabine from PHB-MNPs indicated a pH-dependent pattern, which is a desirable release characteristic, since the pH of the tumor microenvironment and endosomal structures are acidic, while bloodstream and healthy-tissues are neutral. Drug-free PHB-MNPs were not cytotoxic to the SKBR-3 and MCF- 7 cells, whereas the Gemcitabine loaded PHB-MNPs was about two-fold as cytotoxic with respect to free Gemcitabine. In vitro targeting ability of PHB-MNPs was shown under the magnetic field. Conclusion: Considering these facts, we may suggest that these nanoparticles can be a promising candidate for the development of a novel targeted drug delivery system for breast cancer.

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