scholarly journals Common molecular basis of the sentence comprehension network revealed by neurotransmitter receptor fingerprints

Cortex ◽  
2015 ◽  
Vol 63 ◽  
pp. 79-89 ◽  
Author(s):  
Karl Zilles ◽  
Maraike Bacha-Trams ◽  
Nicola Palomero-Gallagher ◽  
Katrin Amunts ◽  
Angela D. Friederici
Keyword(s):  
Molecular Basis ◽  
Sentence Comprehension ◽  
Neurotransmitter Receptor ◽  
Common Molecular Basis

Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects

2015 ◽  
Vol 11 (7) ◽  
pp. 2060-2067
Author(s):  
Yunfeng Wang ◽  
Xiujie Chen ◽  
Lei Liu ◽  
Yuelong Chen ◽  
Hongzhe Ma ◽  
...  
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Molecular Basis ◽  
Health Concern ◽  
Drug Side Effects ◽  
Drug Reactions ◽  
Public Health Concern ◽  
The Common ◽  
Development Failure ◽  
Common Molecular Basis

Drug side effects, or adverse drug reactions (ADRs), have become a major public health concern and often cause drug development failure and withdrawal.

scholarly journals AAA proteins: in search of a common molecular basis

EMBO Reports ◽  
2001 ◽  
Vol 2 (11) ◽  
pp. 980-985 ◽  
Author(s):  
Michael R Maurizi ◽  
Chou‐Chi H Li
Keyword(s):  
Molecular Basis ◽  
Common Molecular Basis

Spinal dysraphism, club feet, and dextrocardia with situs inversus totalis in a neonate: a rare association and review

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Surasak Puvabanditsin ◽  
Akreeti Maskey ◽  
Rannan Kased ◽  
Sadia Haleem ◽  
Rajeev Mehta
Keyword(s):  
Situs Inversus ◽  
Molecular Basis ◽  
Spinal Dysraphism ◽  
Situs Inversus Totalis ◽  
Chromosome 6 ◽  
Case Presentation ◽  
Snp Microarray ◽  
Rare Association ◽  
Common Molecular Basis ◽  
Field Defects

AbstractObjectivesThe spinal dysraphism and situs inversus are a rare association. Since 1909, reports on the coincidence of malformations of the spine and gastrointestinal tract have been published. So far there is no plausible explanation for the association.Case presentationWe report a term female infant with spinal dysraphism with club feet associated with dextrocardia and situs inversus totalis. Whole genome SNP microarray analysis was normal. However, there are extended contiguous regions of allele homozygosity [>8 Mb[megabase]) observed in chromosome 6 and 14.ConclusionsWe report a rare association of spinal dysraphism and situs inversus totalis in a neonate. We review the literature. There have recently been theorized by some to in fact represent nothing more than the presence of two or more polytopic field defects, with all the anomalies present sharing a common molecular basis.

A common molecular basis for membrane docking and functional priming of synaptic vesicles

2009 ◽  
Vol 30 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Léa Siksou ◽  
Frédérique Varoqueaux ◽  
Olivier Pascual ◽  
Antoine Triller ◽  
Nils Brose ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Molecular Basis ◽  
Common Molecular Basis

The molecular biology of temperature-dependent sex determination

1995 ◽  
Vol 350 (1333) ◽  
pp. 297-304 ◽  
Keyword(s):  
Sex Determination ◽  
Molecular Basis ◽  
Current Knowledge ◽  
Temperature Dependent ◽  
The Past ◽  
Egg Incubation ◽  
Heteromorphic Sex Chromosomes ◽  
Substantial Progress ◽  
Common Molecular Basis ◽  
Made In

Many reptiles do not have heteromorphic sex chromosomes and for these species sex is determined during embryogenesis by the temperature of egg incubation rather than at conception. The phenomenon of temperature- dependent sex determination (TSD) was discovered almost thirty years ago, but few advances have been made towards the elucidation of its mechanism. In the past few years substantial progress has been made in the understanding of the molecular basis of XY chromosomal (genetic) sex determination (GSD) through the discovery of SRY. It is now possible to start comparing TSD with GSD. TSD is found in some evolutionarily ancient vertebrates and has been postulated to be the ancestral process from which GSD has evolved. If this is true then the two mechanisms may share a common molecular basis. This paper details the current knowledge of GSD, our progress on the investigation of the involvement of SRY-type proteins, and finally presents some of the problems that need to be resolved to gain an understanding of the molecular basis of TSD.

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