What do the genetic association data say about the high risk of suicide in people with depression? A novel network-based approach to find common molecular basis for depression and suicidal behavior and related therapeutic targets

How can we best translate the success of genome-wide association studies for neurological and neuropsychiatric diseases into therapeutic targets? Reynolds et al. critically assess existing brain-relevant functional genomic annotations and the tools available for integrating such annotations with summary-level genetic association data.

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VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells

Peptides ◽

10.1016/j.peptides.2016.01.014 ◽

2016 ◽

Vol 78 ◽

pp. 30-41 ◽

Cited By ~ 3

Author(s):

Madryssa de Boisvilliers ◽

Florian Perrin ◽

Salima Hebache ◽

Annie-Claire Balandre ◽

Souheyla Bensalma ◽

...

Keyword(s):

High Risk ◽

Neuroblastoma Cells ◽

Therapeutic Targets

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Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

Molecular Cancer Research ◽

10.1158/1541-7786.mcr-14-0337 ◽

2015 ◽

Vol 13 (3) ◽

pp. 470-482 ◽

Cited By ~ 40

Author(s):

Erika A. Newman ◽

Fujia Lu ◽

Daniela Bashllari ◽

Li Wang ◽

Anthony W. Opipari ◽

...

Keyword(s):

High Risk ◽

Therapeutic Targets ◽

Nhej Pathway ◽

Alternative Nhej

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Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects

Molecular BioSystems ◽

10.1039/c5mb00242g ◽

2015 ◽

Vol 11 (7) ◽

pp. 2060-2067

Author(s):

Yunfeng Wang ◽

Xiujie Chen ◽

Lei Liu ◽

Yuelong Chen ◽

Hongzhe Ma ◽

...

Keyword(s):

Public Health ◽

Side Effects ◽

Molecular Basis ◽

Health Concern ◽

Drug Side Effects ◽

Drug Reactions ◽

Public Health Concern ◽

The Common ◽

Development Failure ◽

Common Molecular Basis

Drug side effects, or adverse drug reactions (ADRs), have become a major public health concern and often cause drug development failure and withdrawal.

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Molecular basis of restenosis and potential therapeutic targets

Handbook of Drug-Eluting Stents ◽

10.3109/9780203640265-6 ◽

2005 ◽

pp. 39-45 ◽

Cited By ~ 1

Author(s):

Yiming Yang ◽

Andrew Marks ◽

Steven Marx

Keyword(s):

Molecular Basis ◽

Therapeutic Targets

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AAA proteins: in search of a common molecular basis

EMBO Reports ◽

10.1093/embo-reports/kve229 ◽

2001 ◽

Vol 2 (11) ◽

pp. 980-985 ◽

Cited By ~ 42

Author(s):

Michael R Maurizi ◽

Chou‐Chi H Li

Keyword(s):

Molecular Basis ◽

Common Molecular Basis

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Incorporating prior knowledge about genetic variants into the analysis of genetic association data: An empirical Bayes approach

IEEE/ACM Transactions on Computational Biology and Bioinformatics ◽

10.1109/tcbb.2018.2865420 ◽

2019 ◽

pp. 1-1 ◽

Cited By ~ 4

Author(s):

Ali Karimnezhad ◽

David R. Bickel

Keyword(s):

Prior Knowledge ◽

Genetic Association ◽

Genetic Variants ◽

Empirical Bayes ◽

Empirical Bayes Approach ◽

Association Data ◽

Bayes Approach

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When patients with OCD decide to seek, and not to avoid harm: The problem of suicidality in OCD

Bulletin of the Menninger Clinic ◽

10.1521/bumc.2018.82.4.360 ◽

2018 ◽

Vol 82 (4) ◽

pp. 360-374 ◽

Cited By ~ 1

Author(s):

Gabriela M. Ferreira ◽

Natalie V. Zanini ◽

Gabriela B. de Menezes ◽

Lucy Albertella ◽

Louise Destree ◽

...

Keyword(s):

High Risk ◽

Obsessive Compulsive Disorder ◽

Life Events ◽

Electroconvulsive Therapy ◽

Suicidal Behavior ◽

Stressful Life Events ◽

Obsessive Beliefs ◽

Obsessive Compulsive ◽

Future Studies ◽

Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a chronic, distressing, and disabling condition associated with a high risk of suicidal behavior and death by suicide. In this study, the authors describe two cases of OCD patients who developed recurrent suicidal behaviors in response to stressful life events that appeared to “confirm” their obsessive beliefs (termed “confirmatory events”). In both cases, the authors used accepted strategies for treating suicidality in other contexts (such as antidepressants, lithium, and electroconvulsive therapy), which proved unsuccessful. Future studies should investigate personalized strategies to treat suicidality and prevent suicide in OCD patients.

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