The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

The EGL-13 SOX Domain Transcription Factor Affects the Uterine Cell Lineages in Caenorhabditis elegans

Genetics ◽

10.1093/genetics/165.3.1623 ◽

2003 ◽

Vol 165 (3) ◽

pp. 1623-1628

Author(s):

Hediye Nese Cinar ◽

Keri L Richards ◽

Kavita S Oommen ◽

Anna P Newman

Keyword(s):

Transcription Factor ◽

Cell Division ◽

Caenorhabditis Elegans ◽

Cell Fate ◽

Cell Lineages

Abstract We isolated egl-13 mutants in which the cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the cell fate.

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Phytochrome-mediated regulation of cell division and growth during regeneration and sporeling development in the liverwort Marchantia polymorpha

Journal of Plant Research ◽

10.1007/s10265-015-0724-9 ◽

2015 ◽

Vol 128 (3) ◽

pp. 407-421 ◽

Cited By ~ 25

Author(s):

Ryuichi Nishihama ◽

Kimitsune Ishizaki ◽

Masashi Hosaka ◽

Yoriko Matsuda ◽

Akane Kubota ◽

...

Keyword(s):

Cell Division ◽

Marchantia Polymorpha

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Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis

Nature Communications ◽

10.1038/s41467-021-26165-3 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Natalie M. Clark ◽

Trevor M. Nolan ◽

Ping Wang ◽

Gaoyuan Song ◽

Christian Montes ◽

...

Keyword(s):

Transcription Factor ◽

Cell Division ◽

Network Inference ◽

Phosphorylation Sites ◽

Molecular Signaling ◽

Signaling Events ◽

Spatiotemporal Clustering ◽

Integrated Omics ◽

Omic Data ◽

Integrative Network

AbstractBrassinosteroids (BRs) are plant steroid hormones that regulate cell division and stress response. Here we use a systems biology approach to integrate multi-omic datasets and unravel the molecular signaling events of BR response in Arabidopsis. We profile the levels of 26,669 transcripts, 9,533 protein groups, and 26,617 phosphorylation sites from Arabidopsis seedlings treated with brassinolide (BL) for six different lengths of time. We then construct a network inference pipeline called Spatiotemporal Clustering and Inference of Omics Networks (SC-ION) to integrate these data. We use our network predictions to identify putative phosphorylation sites on BES1 and experimentally validate their importance. Additionally, we identify BRONTOSAURUS (BRON) as a transcription factor that regulates cell division, and we show that BRON expression is modulated by BR-responsive kinases and transcription factors. This work demonstrates the power of integrative network analysis applied to multi-omic data and provides fundamental insights into the molecular signaling events occurring during BR response.

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Balancing dynamic tradeoffs drives cellular reprogramming

10.1101/393934 ◽

2018 ◽

Cited By ~ 1

Author(s):

Kimberley N. Babos ◽

Kate E. Galloway ◽

Kassandra Kisler ◽

Madison Zitting ◽

Yichen Li ◽

...

Keyword(s):

Transcription Factor ◽

Cell Division ◽

Motor Neuron ◽

Molecular Mechanisms ◽

Cell Types ◽

Cellular Reprogramming ◽

Cellular Event ◽

Chemical Factors ◽

Number Of Cells ◽

Transcription And Replication

AbstractAlthough cellular reprogramming continues to generate new cell types, reprogramming remains a rare cellular event. The molecular mechanisms that limit reprogramming, particularly to somatic lineages, remain unclear. By examining fibroblast-to-motor neuron conversion, we identify a previously unappreciated dynamic between transcription and replication that determines reprogramming competency. Transcription factor overexpression forces most cells into states that are refractory to reprogramming and are characterized by either hypertranscription with little cell division, or hyperproliferation with low transcription. We identify genetic and chemical factors that dramatically increase the number of cells capable of both hypertranscription and hyperproliferation. Hypertranscribing, hyperproliferating cells reprogram at 100-fold higher, near-deterministic rates. We demonstrate that elevated topoisomerase expression endows cells with privileged reprogramming capacity, suggesting that biophysical constraints limit cellular reprogramming to rare events.

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The bryophytes Physcomitrium patens and Marchantia polymorpha as model systems for studying evolutionary cell and developmental biology in plants

The Plant Cell ◽

10.1093/plcell/koab218 ◽

2021 ◽

Author(s):

Satoshi Naramoto ◽

Yuki Hata ◽

Tomomichi Fujita ◽

Junko Kyozuka

Keyword(s):

Developmental Biology ◽

Cell Division ◽

Current Knowledge ◽

Flowering Plants ◽

Model Systems ◽

Marchantia Polymorpha ◽

Special Focus ◽

Cellular Mechanisms ◽

Regulatory Pathways ◽

Biological Studies

Abstract Bryophytes are non-vascular spore-forming plants. Unlike in flowering plants, the gametophyte (haploid) generation of bryophytes dominates the sporophyte (diploid) generation. A comparison of bryophytes with flowering plants allows us to answer some fundamental questions raised in evolutionary cell and developmental biology. The moss Physcomitrium patens was the first bryophyte with a sequenced genome. Many cell and developmental studies have been conducted in this species using gene targeting by homologous recombination. The liverwort Marchantia polymorpha has recently emerged as an excellent model system with low genomic redundancy in most of its regulatory pathways. With the development of molecular genetic tools such as efficient genome editing, both P. patens and M. polymorpha have provided many valuable insights. Here, we review these advances, with a special focus on polarity formation at the cell and tissue levels. We examine current knowledge regarding the cellular mechanisms of polarized cell elongation and cell division, including symmetric and asymmetric cell division. We also examine the role of polar auxin transport in mosses and liverworts. Finally, we discuss the future of evolutionary cell and developmental biological studies in plants.

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Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division

PathoGenetics ◽

10.1186/1755-8417-3-1 ◽

2010 ◽

Vol 3 (1) ◽

Cited By ~ 21

Author(s):

Cheryl Shoubridge ◽

May Huey Tan ◽

Tod Fullston ◽

Desiree Cloosterman ◽

David Coman ◽

...

Keyword(s):

Transcription Factor ◽

Cell Division ◽

Nuclear Localization ◽

Subcellular Distribution ◽

Nuclear Localization Sequence ◽

Localization Sequence

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CRISPR/Cas9-Based Genome Editing of Transcription Factor Genes in Marchantia polymorpha

Methods in Molecular Biology - Plant Transcription Factors ◽

10.1007/978-1-4939-8657-6_7 ◽

2018 ◽

pp. 109-126 ◽

Cited By ~ 7

Author(s):

Shigeo S. Sugano ◽

Ryuichi Nishihama

Keyword(s):

Transcription Factor ◽

Genome Editing ◽

Marchantia Polymorpha ◽

Transcription Factor Genes

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Possible Molecular Mechanisms for the Roles of MicroRNA-21 Played in Lung Cancer

Technology in Cancer Research & Treatment ◽

10.1177/1533033819875130 ◽

2019 ◽

Vol 18 ◽

pp. 153303381987513 ◽

Cited By ~ 2

Author(s):

Qiang Wang ◽

Linyou Zhang

Keyword(s):

Lung Cancer ◽

Transcription Factor ◽

Cell Division ◽

A549 Cells ◽

Group Versus ◽

Negative Control ◽

Replication Initiation ◽

Cell Division Cycle ◽

Initiation Factor ◽

Control Group

Background: We aimed to find the possible molecular mechanisms for the roles of microRNA-21 underlying lung cancer development. Methods: MicroRNA-21-5p inhibitor was transfected into A549 cells. Total RNA was isolated from 10 samples, including 3 in control group (A549 cells), 3 in negative control group (A549 cells transferred with microRNA-21 negative control), and 4 in SH group (A549 cells transferred with microRNA-21 inhibitor), followed by RNA sequencing. Then, differentially expressed genes were screened for negative control group versus control group, SH group versus control group, and SH group versus negative control group. Functional enrichment analyses, protein–protein interaction network, and modules analyses were conducted. Target genes of hsa-miR-21-5p and transcription factors were predicted, followed by the regulatory network construction. Results: Minichromosome maintenance 10 replication initiation factor and cell division cycle associated 8 were important nodes in protein–protein interaction network with higher degrees. Cell division cycle associated 8 was enriched in cell division biological process. Furthermore, maintenance 10 replication initiation factor and cell division cycle associated 8 were significantly enriched in cluster 1 and micro-RNA-transcription factor-target genes regulating network. In addition, transcription factor Dp family member 3 (transcription factor of maintenance 10 replication initiation factor and cell division cycle associated 8) and RAD21 cohesin complex component (transcription factor of maintenance 10 replication initiation factor) were target genes of hsa-miR-21-5p. Conclusions: Micro-RNA-21 may play a key role in lung cancer partly via maintenance 10 replication initiation factor and cell division cycle associated 8. Furthermore, microRNA-21 targeted cell division cycle associated 8 and then played roles in lung cancer via the process of cell division. Transcription factor Dp family member 3 and RAD21 cohesin complex component are important transcription factors in microRNA-21-interfered lung cancer.

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