Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy: A Multicenter Observational Study

Background: Rational drug prescribing can be defined as appropriate drugs prescribed in the right dose, at correct time intervals and for a sufficient duration. Alcoholic Liver Disease (ALD) and its complications are the principle cause for morbidity and mortality rate and accounts for elevated social and economic costs. The drug use will be a challenge for the physicians as there was no specific treatment for ALD, and decisions regarding treatment are critically depends on the symptoms and complications.Methods: A uni-centric prospective (observational) study was conducted for a period of 6months, to evaluate the current prescribing patterns used in treating ALD. All the patients admitted with diagnosis of ALD in General medicine department, both male and female medical wards were included in the study. General medicine outpatient department, special population such as pregnancy and psychiatry, patients below 18years and those who are not willing to sign in informed consent form was excluded from the study.Results: Number of males (98.02%) between age group 31-40years (29.6%) was more prone when compared to females (1.77%). Portal hypertension (30.35%) followed by jaundice (11.30%) and Ascites (10.71%) were frequently observed complications associated co-morbidities with ALD. WHO prescribing indicators showed deviation from there standard reference values. Diuretics (15.73%), antibiotics (13.14%), vitamin supplements (11.11%) and antacids (10.13%) categories were the most commonly prescribed for patients. The drugs prescribed from NLEM-2015 (82.11%) shows deviation from standard values.Conclusions: Futhermore, multi-centered studies should be conducted to draw best results on prescribing patterns of ALD in India.

Download Full-text

Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: a prospective observational study

BMC Gastroenterology ◽

10.1186/s12876-021-02032-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Masato Shizuku ◽

Hiroyuki Kimura ◽

Hideya Kamei ◽

Shinichi Kishi ◽

Tatsuya Tokura ◽

...

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Observational Study ◽

Alcoholic Liver Disease ◽

Prospective Observational Study ◽

Short Form ◽

Depression Scale ◽

Preoperative Period ◽

Psychosocial Characteristics ◽

Significant Difference

Abstract Background There are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of the recognition that ALD is fundamentally self-inflicted. However, it is unclear whether psychosocial characteristics of ALD are different from that of non-alcoholic liver disease (NALD) in the selection of liver transplantation (LT) recipients. We aimed to clarify the psychosocial characteristics of ALD recipients (ALD-R)/ALD recipient candidates (ALD-RC) and NALD recipients (NALD-R)/ NALD recipient candidates (NALD-RC). Methods From 2011 to 2019, 75 patients were enrolled in this prospective observational study (ALD-RC, n = 19; NALD-RC, n = 56), LT were carried out as follow; ALD-R, n = 6; NALD-R, n = 52. We evaluated psychosocial characteristics in the preoperative period and 3, 12 months after LT (ALD-R, n = 3/3; NALD-R, n = 28/25). The following scales were used to evaluate psychosocial characteristics: Visual Analogue Scale, Alcohol Use Disorders Identification Test, Hospital Anxiety and Depression Scale, Beck Depression Inventory, Brief Evaluation of Medication Influences and Beliefs, Social Support Questionnaire (SSQ), Temperament and Character Inventory, Parental Bonding Instrument (PBI), the Short Form Health Survey (SF-36). Results When evaluating on the basis of abstinence rule, a comparison of ALD-RC and NALD-RC in the preoperative period identified similar patterns of psychosocial characteristics, except that the NALD-RC scored higher on the PBI item “overprotection from mother” (P < 0.05). The only significant difference between ALD-R and NALD-R after liver transplantation was in SSQ scores at 3 months. Conclusion The psychosocial characteristics of ALD-RC and NALD-RC may be similar when evaluated on the basis of Japan’s abstinence rule. This result also imply that the psychosocial characteristics of ALD-RC may differ from the previously reported psychosocial characteristics of alcohol dependent patients. These findings have the potential to provide helpful information for the evaluation of ALD-RC.

Download Full-text

Heptral® (Ademetionine) in Patients with Intrahepatic Cholestasis due to Chronic Alcoholic Liver Disease: Results of a Multicentre Observational Study in Indian Patients

Journal of Clinical and Experimental Hepatology ◽

10.1016/j.jceh.2014.02.065 ◽

2014 ◽

Vol 4 ◽

pp. S30

Author(s):

Ravi Shankar ◽

Tina Singh ◽

Gourdas Choudhuri

Keyword(s):

Liver Disease ◽

Observational Study ◽

Alcoholic Liver Disease ◽

Intrahepatic Cholestasis ◽

Chronic Alcoholic ◽

Indian Patients

Download Full-text

Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study

Mayo Clinic Proceedings ◽

10.1016/j.mayocp.2017.02.019 ◽

2017 ◽

Vol 92 (6) ◽

pp. 899-907 ◽

Cited By ~ 8

Author(s):

Antonio J. Chamorro ◽

Beatriz Rosón-Hernández ◽

José-A. Medina-García ◽

Roberto Muga-Bustamante ◽

Joaquín Fernández-Solá ◽

...

Keyword(s):

Observational Study ◽

Wernicke Encephalopathy ◽

Multicenter Observational Study

Download Full-text

Psychosocial characteristics of alcoholic and non-alcoholic liver disease recipient candidates in liver transplantation: A prospective observational study

10.21203/rs.3.rs-362902/v1 ◽

2021 ◽

Author(s):

Masato Shizuku ◽

hiroyuki kimura ◽

Hideya Kamei ◽

Shinichi Kishi ◽

Tatsuya Tokura ◽

...

Keyword(s):

Liver Transplantation ◽

Liver Disease ◽

Observational Study ◽

Alcoholic Liver Disease ◽

Prospective Observational Study ◽

Short Form ◽

Psychosocial Aspects ◽

Preoperative Period ◽

Psychosocial Characteristics ◽

Significant Difference

Abstract Background/AimThere are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of the recognition that ALD is fundamentally self-inflicted. However, it is unclear whether stigmatization of ALD based on psychosocial aspects is warranted in the selection of liver transplantation (LT) recipients. We aimed to clarify the psychosocial characteristics of ALD recipients (ALD-R)/ALD recipient candidates (ALD-RC) and non-ALD recipients (NALD-R)/non-ALD recipient candidates (NALD-RC).MethodsFrom 2011 to 2019, 75 patients were enrolled in this prospective observational study (ALD-RC, n = 19; NALD-RC, n = 56), LT were carried out as follow; ALD-R, n=6; NALD-R, n=52. We evaluated psychosocial characteristics in the preoperative period and 3, 12 months after LT (ALD-R, n = 3/3; NALD-R, n = 28/25). The following scales were used to evaluate psychosocial characteristics: Visual Analogue Scale, Alcohol Use Disorders Identification Test, Hospital Anxiety and Depression Scale, Beck Depression Inventory, Brief Evaluation of Medication Influences and Beliefs, Social Support Questionnaire (SSQ), Temperament and Character Inventory, Parental Bonding Instrument (PBI), the Short Form Health Survey (SF-36).ResultsA comparison of ALD-RC and NALD-RC in the preoperative period identified similar patterns of psychosocial characteristics, except that the NALD-RC scored higher on the PBI item “overprotection from mother” (P < 0.05). The only significant difference between ALD-R and NALD-R after liver transplantation was in SSQ scores at 3 months. ConclusionThe psychosocial characteristics of ALD-RC and NALD-RC were similar. Therefore, stigmatization of ALD-RC based on psychosocial aspects is unwarranted and appropriate evaluation is needed.

Download Full-text

ASSESSMENT OF CLINICAL PROFILE AND TREATMENT CHART REVIEW FOR ALCOHOLIC LIVER DISEASE (ALD) PATIENTS: A PROSPECTIVE AND OBSERVATIONAL STUDY

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1945 ◽

2018 ◽

Vol 8 (5) ◽

pp. 437-441

Author(s):

Siddaruda Malleshappa Biradar ◽

Dhanavanti Gelada ◽

MV Mounika ◽

P Meghana ◽

M Bharathi ◽

...

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Drug Therapy ◽

Observational Study ◽

Alcoholic Liver Disease ◽

Chart Review ◽

Clinical Profile ◽

Patient Counselling ◽

Optimal Drug

Background/Aim: Alcohol remains one of most common cause of liver disease in India, hence the present study was undertaken to assess the clinical profile and treatment chart review of alcoholic liver disease (ALD) patients. Materials and Methods: Hospital based prospective and observational study was carried out for a period of nine months in a tertiary care hospital of south India. All the patients of either gender diagnosed with ALD were enrolled in the study and patient consent was taken, the data related to the patients of ALD were documented in a structured patient data collection form and analyzed carefully. Results: ALD was mainly affected in male with age group of 41-50 years.Out of 130 patients 43.8% patients were suffered from Fatty Liver disease while 23.1% were suffered from Alcoholic Hepatitis and 33.1% were suffered from Cirrhosis of Liver. The secondary developments to ALD were portal hypertension (13.8%) followed by Ascities (10.8%) and Hepatitis (10%). The major risk factors involved in ALD was alcohol per se (52.3%) and, alcohol and smoking exaggerate the disease condition. The Periodic (61.5%) and regular basis (38.5%) of alcoholism for chronic period of time may land up with ALD. Polypharmacy is essential for the treatment of ALD as it inoved multiple secondary development to ALD. The patients were intervened and counselled on their individual basis for ALD consequences, and motivated for cessation of alcohol and smoking. Conclusion: The study enlightens that the early diagnosis and its beneficial outcomes that can exponentially curtail the mortality rate of ALD. Similarly the optimal drug therapy regimen and patient counseling may improve the patient’s quality of life. Keywords: Alcoholic Liver Disease; Optimal Drug Therapy; Patient Counselling; Improved Quality of Life

Download Full-text

Phosphatidylethanol for Monitoring Alcohol Use in Liver Transplant Candidates: An Observational Study

Journal of Clinical Medicine ◽

10.3390/jcm9093060 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3060 ◽

Cited By ~ 1

Author(s):

Pablo Barrio ◽

Antoni Gual ◽

Anna Lligoña ◽

Lidia Teixidor ◽

Wolfgang Weinmann ◽

...

Keyword(s):

Mass Spectrometry ◽

Liver Transplantation ◽

Liver Disease ◽

Alcohol Use ◽

Observational Study ◽

Alcoholic Liver Disease ◽

False Negative ◽

Complex Process ◽

Self Reports ◽

Transplant Candidates

Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phosphatidylethanol (PEth) has been recently tested in alcoholic liver disease patients, but more evidence is needed, especially in comparison with other direct biomarkers. We conducted an observational study among patients awaiting liver transplantation. We analyzed Peth in blood, ethylglucuronide (EtG) in hair and urine and ethylsulphate (EtS) in urine, using mass spectrometry methods. In addition, transaminases, and self-reports were analyzed. A total of 50 patients were included (84% men, mean age 59 years (SD = 6)). 18 patients (36%) screened positive for any marker. Self-reports were positive in 3 patients. EtS was the biomarker with more positive screens. It also was the most frequently exclusive biomarker, screening positive in 7 patients who were negative for all other biomarkers. PEth was positive in 5 patients, being the only positive biomarker in 2 patients. It showed a false negative in a patient admitting alcohol use the previous week and screening positive for EtG and EtS. Hair EtG was positive in 3 patients who had negative Peth, EtG. EtG did not provide any exclusive positive result.A combination of biomarkers seems to be the best option to fully ascertain abstinence in this population. Our study suggest EtS might also play a significant role.

Download Full-text