DJ-1-Nrf2 axis is activated upon murine β-coronavirus infection in the CNS

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

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Mechanisms of liver damage in COVID-19

Medical alphabet ◽

10.33667/2078-5631-2020-19-39-46 ◽

2020 ◽

Vol 1 (19) ◽

pp. 39-46

Author(s):

T. V. Pinchuk ◽

N. V. Orlova ◽

T. G. Suranova ◽

T. I. Bonkalo

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Transplantation ◽

Risk Factor ◽

Liver Disease ◽

Liver Function ◽

Liver Damage ◽

The World ◽

Coronavirus Infection ◽

The Impact ◽

Analyze Data

At the end of 2019, a new coronavirus (SARS-CoV-2) was discovered in China, causing the coronavirus infection COVID-19. The ongoing COVID-19 pandemic poses a major challenge to health systems around the world. There is still little information on how infection affects liver function and the significance of pre-existing liver disease as a risk factor for infection and severe COVID-19. In addition, some drugs used to treat the new coronavirus infection are hepatotoxic. In this article, we analyze data on the impact of COVID-19 on liver function, as well as on the course and outcome of COVID-19 in patients with liver disease, including hepatocellular carcinoma, or those on immunosuppressive therapy after liver transplantation.

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SOME FEATURES OF CRIMINAL PROCEDURE IN RUSSIA IN CONNECTION WITH THE SPREAD OF CORONAVIRUS INFECTION (COVID-19)

Sociopolitical sciences ◽

10.33693/2223-0092-2020-10-3-149-154 ◽

2020 ◽

Vol 10 (3) ◽

pp. 149-154

Author(s):

YURI FRANCIFOROV ◽

◽

MARINA BARANOVA

Keyword(s):

Preliminary Investigation ◽

Preventive Measure ◽

Judicial System ◽

Emergency Situations ◽

Judicial Proceedings ◽

Coronavirus Infection ◽

The Russian Federation ◽

The Government ◽

Judicial Actions ◽

Emergency Measures

The purpose of the article is to consider the peculiarities of investigative and judicial actions that are caused by their postponement, the inability to attract a lawyer, as well as the suspension of the preliminary investigation during the period of emergency measures taken by the government of the Russian Federation in response to the outbreak of the coronavirus infection pandemic (COVID-19). The authorsanalyze the features of the courts activity in connection with the coronavirus pandemic, which is associated with minimizing the personal reception of citizens and submitting documents via electronic Internet reception offices of courts or by Russian Post, as well as the possibility of conducting online court sessions. The authors come to the conclusion that the judicial system was not sufficiently prepared for the pandemic, and therefore it is urgently necessary to adopt a special normative act that would regulate the implementation of judicial proceedings in emergency situations, allowing to continue to consider urgent cases, including materials on the election, extension, cancellation or change of a preventive measure.

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ADDRESSING THE ISSUE OF СOVID-19, SARS-COV-2 VIRUS AND THE DISEASE

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2020-99-6-15-31 ◽

2020 ◽

Vol 99 (6) ◽

pp. 15-31

Author(s):

A.A. Korenkova ◽

◽

E.M. Mayorova ◽

V.V. Bahmetjev ◽

M.V. Tretyak ◽

...

Keyword(s):

Public Health ◽

Immune Responses ◽

Molecular Mechanisms ◽

Herd Immunity ◽

Significant Problem ◽

Prevention Measures ◽

Optimal Therapy ◽

The World ◽

Public Health Challenge ◽

Coronavirus Infection

The new coronavirus infection has posed a major public health challenge around the world, but new data on the disease raises more questions than answers. The lack of optimal therapy is a significant problem. The article examines the molecular mechanisms of SARS-CoV-2 infection and the pathogenesis of COVID-19, special attention is paid to features of pathological processes and immune responses in children. COVID-19 leads to a wide diversity of negative outcomes, many of which can persist for at least months. Many of the consequences have yet to be identified. SARS-CoV-2 may provoke autoimmune reactions. Reinfection, herd immunity, vaccines and other prevention measures are also discussed in this review.

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Media Representation of the Pandemic: a Metaphorical Image of War (based on American Newspapers)

Nauchnyy dialog ◽

10.24224/2227-1295-2020-8-69-83 ◽

2020 ◽

Vol 1 (8) ◽

pp. 69-83

Author(s):

N. S. Dankova ◽

E. V. Krekhtunova

Keyword(s):

Critical Discourse Analysis ◽

Media Coverage ◽

Critical Discourse ◽

Media Representation ◽

Martial Law ◽

War Zone ◽

Mass Consciousness ◽

The Media ◽

Coronavirus Infection ◽

Theoretical Foundations

The article is devoted to the study of the media representation features of the situation of coronavirus infection spread. The material was articles published in American newspapers. It is shown that the metaphorical model "War" is widely used in media coverage of the pandemic. The relevance of the work is due to the ability of the media to influence the mass consciousness. The methodological basis of the research is formed by critical discourse analysis, which establishes the connection between language and social reality. The article provides an overview of works devoted to the study of metaphor. The theoretical foundations for the study of metaphorical modeling are given. In the course of the analysis, the linguistic means of updating the metaphorical model "War" were revealed. The authors note that this metaphorical model is represented by such frames as “War and its characteristics”, “Participants in military action”, “War zone”, “Enemy actions”, “Confronting the enemy”. It is shown that modern reality is presented in the media as martial law, the coronavirus is positioned in the media as a cruel and merciless enemy seeking to take over the world, the treatment of the disease is represented as a fight against the enemy. It is concluded that the use of the metaphorical model "War" is one of the ways to conceptualize the spread of coronavirus.

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Broad beans ( Vicia faba ) and the potential to protect from COVID-19 coronavirus infection

Sudanese Journal of Paediatrics ◽

10.24911/sjp.1061585398078 ◽

2020 ◽

pp. 10-12

Author(s):

Mutasim Khalil ◽

Mustafa Salih ◽

Ali Mustafa

Keyword(s):

Vicia Faba ◽

Broad Beans ◽

Coronavirus Infection

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Review on Efficacy of Herbal Antiviral Drugs against COVID-19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3552 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1116-1121

Author(s):

Pooja P. Thakre ◽

Vinod Ade ◽

Shweta Parwe

Keyword(s):

Physical Contact ◽

Research Articles ◽

Herbal Drugs ◽

Plant Origin ◽

Respiratory Pathway ◽

Traditional Medicines ◽

The Past ◽

Primary Health ◽

Coronavirus Infection ◽

Novel Coronavirus

Coronavirus disease (CoViD-19) is an infection of the respiratory system caused due to various viruses affects the respiratory pathway, and it can spread from one person to another by coughing, sneezing or physical contact. Commonly include cough, cold, fever are the symptoms. Viral diseases increase worldwide concern, including emerging and chronic viruses. The invention of new anti-viral drugs from plants has implicit in the past. The Coronavirus disease 19 (COVID-19) caused due to severe acute respiratory syndrome, which is a transmittable and pathogenic viral infection. Several traditional medicines of plant origin having antimicrobial and anti-inflammatory properties some have been studied for their anti-viral properties and immune-modulating effects. Herbal drugs are now in massive requirement in the developing countries for primary health care not because of their economical but also for better civilising adequacy, improved compatibility with the human body and significantly fewer side effects. This review gives an overview of some critical traditionally used medicinal herbs with anti-viral properties—the literature regarding the drugs of this group, collected from Ayurveda classics. Research articles are collected from published material and discussed per therapeutic actions. Most of the Herbs are with Katu Rasa (pungent) and Ushna Virya (hot potency). They are indicated in diseases, viz. Kasa (cough), Shwas (asthma), Krumi (worm/ infection). Krumihara property drugs which are correlated with anti-viral action helps to prevent against Novel coronavirus infection.

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Association and treatment of diabetes in patients affected by Covid-19

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.3591 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 1198-1201

Author(s):

Syed Yasir Afaque

Keyword(s):

Diabetes Mellitus ◽

Prognostic Value ◽

Heart Diseases ◽

The Novel ◽

The World ◽

Treatment Of Diabetes ◽

Coronavirus Infection ◽

Composite Outcomes ◽

Novel Coronavirus ◽

The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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