scholarly journals BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease

EBioMedicine ◽  
2019 ◽  
Vol 43 ◽  
pp. 424-434 ◽  
Author(s):  
Ekaterina Eremenko ◽  
Kritika Mittal ◽  
Omer Berner ◽  
Nikita Kamenetsky ◽  
Anna Nemirovsky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
T Cells ◽  
Targeted Drug Delivery ◽  
Cd4 T Cells ◽  
Amyloid Β ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Well-defined single polymer nanoparticles for the antibody-targeted delivery of chemotherapeutic agents

2015 ◽  
Vol 6 (8) ◽  
pp. 1286-1299 ◽  
Author(s):  
D. D. Lane ◽  
D. Y. Chiu ◽  
F. Y. Su ◽  
S. Srinivasan ◽  
H. B. Kern ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Raft Polymerization ◽  
Chemotherapeutic Agents ◽  
Polymer Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Molecular Weights ◽  
Delivery Vehicles ◽  
Targeted Drug

Second generation polymeric brushes with molecular weights in excess of 106 Da were synthesize via RAFT polymerization for use as antibody targeted drug delivery vehicles.

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

scholarly journals Ultra‐Small Biomimetic Nanoparticles for Alzheimer’s Disease Targeted Drug Delivery

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Katyayani Tatiparti ◽  
Mohd Ahmar Rauf ◽  
Samaresh Sau ◽  
R. Alzhrani ◽  
Arun Iyer
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Targeted Drug Delivery ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug

A Conditionally Releasable “Do not Eat Me” CD47 Signal Facilitates Microglia‐Targeted Drug Delivery for the Treatment of Alzheimer's Disease

2020 ◽  
Vol 30 (24) ◽  
pp. 1910691 ◽  
Author(s):  
Lun Zhang ◽  
Xiao‐ge Liu ◽  
Dong‐qun Liu ◽  
Xiao‐lin Yu ◽  
Ling‐xiao Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Targeted Drug Delivery ◽  
Targeted Drug

scholarly journals Editorial: Stem Cells as Targeted Drug Delivery Vehicles

2020 ◽  
Vol 11 ◽  
Author(s):  
Gina D. Kusuma ◽  
Jessica E. Frith ◽  
Christopher G. Sobey ◽  
Rebecca Lim
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

scholarly journals Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Xiaojiao Yu ◽  
Ian Trase ◽  
Muqing Ren ◽  
Kayla Duval ◽  
Xing Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Active Targeting ◽  
Physical Interaction ◽  
Computational Simulations ◽  
Delivery Methods ◽  
Passive Targeting ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.

scholarly journals Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics

2021 ◽  
Vol 22 (19) ◽  
pp. 10794
Author(s):  
Hagar M. Soliman ◽  
Ghada A. Ghonaim ◽  
Shaza M. Gharib ◽  
Hitesh Chopra ◽  
Aya K. Farag ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorders ◽  
Adverse Reactions ◽  
Extracellular Vesicle ◽  
Clinical Applications ◽  
Drug Delivery Vehicles ◽  
Pathophysiological Role ◽  
Delivery Vehicles

Exosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such as Parkinson’s and Alzheimer’s disease (AD). EXOs have shown the potential to carry pathological and therapeutic cargo; thus, researchers have harnessed EXOs in drug delivery applications. EXOs have shown low immunogenicity as natural drug delivery vehicles, thus ensuring efficient drug delivery without causing significant adverse reactions. Recently, EXOs provided potential drug delivery opportunities in AD and promising future clinical applications with the diagnosis of NDD and were studied for their usefulness in disease detection and prediction prior to the emergence of symptoms. In the future, the microfluidics technique will play an essential role in isolating and detecting EXOs to diagnose AD before the development of advanced symptoms. This review is not reiterative literature but will discuss why EXOs have strong potential in treating AD and how they can be used as a tool to predict and diagnose this disorder.

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