Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China

ObjectivesAbout 11%–30% of individuals with impaired fasting plasma glucose (IFG) have type 2 diabetes mellitus (T2DM), diagnosed by the 75 g oral glucose tolerance test (75 g OGTT). This study investigated (1) the prevalence and cut-off levels for fasting plasma glucose (FPG) and glycated haemoglobin A1c (HbA1c) in IFG individuals that most effectively predict the presence of T2DM diagnosed by a 75 g OGTT; (2) the predictors associated with T2DM; and (3) the pathophysiological characteristics of patients with IFG.Materials and methodsA single-centre, cross-sectional study was conducted in a primary care setting. A standard 75 g OGTT was performed on 123 subjects with IFG. Their beta-cell function and insulin resistance were calculated through plasma glucose and insulin levels monitored during the 75 g OGTT.ResultsIn the IFG subjects, the prevalence of T2DM using the 2-hour postload plasma glucose (2hPG) criterion was 28.5%. Pre-diabetes and normal glucose metabolism were found in 48.7% and 22.8%, respectively, by 75 g OGTT. An HbA1c level ≥6.0% or FPG ≥5.9 mmol/L were the optimal cut-off thresholds for the prediction of the presence of T2DM. HbA1c had a sensitivity of 76.7% and specificity of 55.7% (95% CI 57.7% to 90.1% and 95% CI 43.3% to 67.6%, respectively), while FPG had a sensitivity of 85.7% and specificity of 23.9% (95% CI 69.7% to 95.2% and 95% CI 15.4% to 34.1%, respectively). The presence of metabolic syndrome, a higher HbA1c and higher FPG levels were associated with the risk of T2DM in the Thai IFG population.ConclusionsAlmost one-third of the people with IFG had T2DM diagnosed by the 2hPG criterion. HbA1c was more effective than FPG in predicting the presence of T2DM in the IFG subjects. IFG individuals with HbA1c≥6.0% or FPG≥5.9 mmol/L should be advised to undergo a 75 g OGTT to detect T2DM earlier than otherwise.

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The relationship between long-term exposure to PM2.5 and fasting plasma glucose levels in Chinese children and adolescents aged 6–17 years: A national cross-sectional study

The Science of The Total Environment ◽

10.1016/j.scitotenv.2019.136211 ◽

2020 ◽

Vol 710 ◽

pp. 136211

Author(s):

Mao Wang ◽

Lijuan Gong ◽

Zhiyong Zou ◽

Aili Jiang ◽

Haijun Wang ◽

...

Keyword(s):

Children And Adolescents ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

The Relationship ◽

Chinese Children And Adolescents

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Characteristics of different risk factors and fasting plasma glucose for identifying GDM when using IADPSG criteria: a cross-sectional study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-018-1875-1 ◽

2018 ◽

Vol 18 (1) ◽

Author(s):

Maryam Saeedi ◽

Ulf Hanson ◽

David Simmons ◽

Helena Fadl

Keyword(s):

Risk Factors ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Fasting Plasma ◽

Iadpsg Criteria

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Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2018-025524 ◽

2019 ◽

Vol 9 (10) ◽

pp. e025524 ◽

Cited By ~ 1

Author(s):

Ling-Ling Huang ◽

Dong-Hui Guo ◽

Hui-Yan Xu ◽

Song-Tao Tang ◽

Xiao Xiao Wang ◽

...

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Liver Enzymes ◽

Southern China ◽

Cross Sectional Study ◽

Normal Weight ◽

Sectional Study ◽

Cross Sectional ◽

Fasting Plasma ◽

Overweight Or Obesity

ObjectiveAccording to several studies, liver enzymes levels are associated with fasting plasma glucose (FPG) levels. However, the association stratified by body mass index (BMI) remains to be elucidated, especially in Southern China. Therefore, the aim of this study was to investigate the correlation between liver enzymes levels and FPG levels stratified by BMI in Southern China.DesignCross-sectional study.Participants and setting3056 individuals participated in real-time interviews and blood tests in Southern China. Participants were divided into three groups (underweight, normal weight and overweight or obesity) based on BMI cut-offs.Main outcome measuredPartial correlation analysis was performed to investigate the relationship between FPG levels and liver tests. Multivariate logistic regression analyses were applied to calculate the adjusted ORs for FPG levels based on liver enzymes levels.ResultsThere was no association between liver enzymes and FPG either in the underweight group or in the normal weight group; however, a significant correlation was observed in the overweight or obesity group (alanine transaminase (ALT), p<0.01; aspartate aminotransferase (AST), p<0.05). After adjusting for confounding factors, the highest tertiles of ALT still remained significantly positively related to FPG levels in the overweight or obesity group, with an OR of 2.205 (95% CI 1.442 to 3.371) for the 5.56≤FPG<7.00 mmol/L vs the FPG<5.56 mmol/L group and with an OR of 2.297 (95% CI 1.017 to 5.187) for the FPG≥7.00 mmol/L vs the FPG<5.56 mmol/L group, but this correlation was not found for AST.ConclusionsThe association of liver enzymes levels with FPG levels differed based on different BMI cut-offs. ALT levels were significantly positively associated with FPG levels in the overweight or obesity group, but not in the other two groups; AST levels were not associated with FPG levels in any group.

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Fasting Plasma Glucose, Self-Appraised Diet Quality and Depressive Symptoms: A US-Representative Cross-Sectional Study

Nutrients ◽

10.3390/nu9121330 ◽

2017 ◽

Vol 9 (12) ◽

pp. 1330 ◽

Cited By ~ 2

Author(s):

Erin Hoare ◽

Sarah Dash ◽

Pia Varsamis ◽

Garry Jennings ◽

Bronwyn Kingwell

Keyword(s):

Depressive Symptoms ◽

Diet Quality ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Fasting Plasma

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The association between elevated fasting plasma glucose levels and carotid intima-media thickness in non-diabetic adults: a population-based cross-sectional study

Oncotarget ◽

10.18632/oncotarget.22302 ◽

2017 ◽

Vol 8 (67) ◽

pp. 111053-111063 ◽

Cited By ~ 1

Author(s):

Yalin Guan ◽

Changshen Yu ◽

Min Shi ◽

Jingxian Ni ◽

Yanan Wu ◽

...

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Population Based ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

Media Thickness

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Gender Differences in Cardiometabolic Risk Factors in Metabolically Healthy Normal Weight Adults with Central Obesity

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-119877 ◽

2017 ◽

Vol 126 (05) ◽

pp. 309-315

Author(s):

Katarína Šebeková ◽

Melinda Csongová ◽

Radana Gurecká ◽

Zora Krivošíková ◽

Jozef Šebek

Keyword(s):

Blood Pressure ◽

Waist Circumference ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Central Obesity ◽

Cross Sectional Study ◽

Normal Weight ◽

Cross Sectional ◽

Fasting Plasma ◽

Metabolically Healthy

AbstractWe investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0.5, regardless of waist circumference). Data on blood pressure, glucose homeostasis, lipid profile, renal function, high-sensitive C-reactive protein (hsCRP), uric acid, adiponectin, leptin, and soluble receptor for advanced glycation end products were compared between the groups, separately in males and females. 5.7% of males and 6.9% of females presented WHtR ≥0.5. Compared with centrally lean subjects, those with central obesity had higher BMI-adjusted fasting plasma glucose (p<0.001), and leptin levels (p<0.05); females also presented higher blood pressure (p<0.001), while males had higher hsCRP concentrations (p=0.021). These changes associated with significantly higher BMI-adjusted odds to present fasting plasma glucose >5.6 mmol/l in both genders, higher odds to present hsCRP >3 mg/l in males, and those to present elevated blood pressure in females. Our analysis suggests that in metabolically healthy normal weight subjects WHtR ≥0.5 might indicate “early increased health risk”.

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Dietary Fibre Intake in Type 2 and New-Onset Prediabetes/Diabetes after Acute Pancreatitis: A Nested Cross-Sectional Study

Nutrients ◽

10.3390/nu13041112 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1112

Author(s):

Xinye Li ◽

Wandia Kimita ◽

Jaelim Cho ◽

Juyeon Ko ◽

Sakina H. Bharmal ◽

...

Keyword(s):

Acute Pancreatitis ◽

Glucose Metabolism ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Dietary Fibre ◽

Glycated Haemoglobin ◽

Cross Sectional Study ◽

Cross Sectional ◽

Fasting Plasma ◽

Habitual Intake

The association between intake of dietary fibre and glucose metabolism has been extensively investigated in numerous metabolic disorders. However, little is known about this association in individuals after an attack of acute pancreatitis (AP). The aim was to investigate the associations between intake of dietary fibre and markers of glucose metabolism in individuals with new-onset prediabetes or diabetes after acute pancreatitis (NODAP), pre-exiting type 2 prediabetes or diabetes, and normoglycaemia after acute pancreatitis. This cross-sectional study was nested within the parent prospective longitudinal cohort study. The studied markers of glucose metabolism were fasting plasma glucose and glycated haemoglobin. Habitual intake of dietary fibre was determined using the EPIC-Norfolk food frequency questionnaire. Multivariable linear regression analyses were conducted. The study included a total of 108 individuals after AP. In the NODAP group, increased intakes of total fibre (β = −0.154, p = 0.006), insoluble fibre (β = −0.133, p = 0.01), and soluble fibre (β = −0.13, p = 0.02) were significantly associated with a reduction in fasting plasma glucose. Increased intakes of vegetables (β = −0.069, p = 0.004) and nuts (β = −0.039, p = 0.038) were significantly associated with a reduction in fasting plasma glucose. Increased intake of nuts (β = −0.054, p = 0.001) was also significantly associated with a reduction in glycated haemoglobin. None of the above associations were significant in the other study groups. Habitual intake of dietary fibre was inversely associated with fasting plasma glucose in individuals with NODAP. Individuals after an attack of AP may benefit from increasing their intake of dietary fibre (specifically, vegetables and nuts) with a view to preventing NODAP.

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Trends in diabetes prevalence, awareness, treatment, control in Yangon, Myanmar between 2004-2014

European Journal of Public Health ◽

10.1093/eurpub/ckz185.446 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

W P Aung ◽

E Bjertness ◽

H Stigum ◽

A S Htet ◽

M K Kjøllesdal

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Rural Areas ◽

Diabetes Prevalence ◽

World Health ◽

Treatment Rate ◽

Cross Sectional ◽

Glucose Levels ◽

Fasting Plasma ◽

And Control

Abstract Background In 2004, a survey in Yangon Region was conducted as the first STEP survey in Myanmar, which was repeated in 2014, assessing diabetes prevalence. Whether there have been any changes over time in the awareness, treatment and control status of diabetes is not known. The study aimed to assess changes in the prevalence, awareness, treatment and control of diabetes from 2004 to 2014, among adults in Yangon region. Methods The study was conducted in urban and rural areas of Yangon region, Myanmar, using two cross-sectional household based studies, in accordance with World Health Organization STEPS methodology. Men and women aged 25-74 years old participated in the studies (n = 4448 in 2004) and (n = 1372 in 2014). Logistic and linear regression were performed and outcome variables were diabetes and fasting plasma glucose. Results The overall age-standardized prevalence of diabetes were 8.3% (95% CI 6.5-10.6) in 2004 and 10.2% (7.6-13.6) in 2014 (p = 0.296). The diabetes prevalence increased from 2004 to 2014 only among participants aged ≥60 years, from 14.6% (11.7-18.1) to 31.9% (21.1-45.0) (p = 0.009). Awareness of having diabetes increased between 2004 and 2014 (44.3% (39.2, 49.6) to 69.4% (62.9-75.2)) (p < 0.001). Among participants who were aware of having diabetes, the proportion under treatment had increased between 2004 and 2014 from 55.1% (46.8-63.1) to 68.6% (61.5-74.8) (p = 0.015). There were no increase between 2004 and 2014 in the proportion of participants with controlled diabetes. After adjustments for age, sex and education, mean fasting plasma glucose levels in 2014 was 0.56 mmol/l (0.26-0.84) higher than in 2004. Conclusions The studies to monitor the development of diabetes prevalence in Myanmar are needed. Preventive measures to halt increases prevalence, to increase the detection rate of undiagnosed DM also treatment rate and to help people with diabetes to control their situation are needed. Key messages Mean plasma glucose levels were higher in 2014 than in 2004, but an increase in DM prevalence during this period was seen only among the oldest participants. The proportion of women being aware of having DM, as well as the proportion under treatment for most groups, had increased, however not the proportion under control.

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