Outbreak of Arcobacter butzleri? An emerging enteropathogen

2021 ◽  
Author(s):  
Carlos Ruiz de Alegría Puig ◽  
Marta Fernández Martínez ◽  
Daniel Pablo Marcos ◽  
Jesús Agüero Balbín ◽  
Jorge Calvo Montes
Keyword(s):  
Arcobacter Butzleri

Nomenclature Abstract for Arcobacter butzleri (Kiehlbauch et al. 1991) Vandamme et al. 1992.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Sarah Wigley ◽  
George M Garrity
Keyword(s):  
Arcobacter Butzleri

scholarly journals Occurrence and Antimicrobial Resistance of Arcobacter spp. Recovered from Aquatic Environments

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 288
Author(s):  
Sonia Sciortino ◽  
Pietro Arculeo ◽  
Vincenzina Alio ◽  
Cinzia Cardamone ◽  
Luisa Nicastro ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Tetracycline Resistance ◽  
Multi Drug Resistance ◽  
Genetic Determinants ◽  
Antibiotic Resistant ◽  
Resistance Profile ◽  
Antimicrobial Resistance Profile ◽  
Drug Resistance Profile ◽  
Arcobacter Butzleri ◽  
Seawater Samples

Arcobacter spp. are emerging waterborne and foodborne zoonotic pathogens responsible for gastroenteritis in humans. In this work, we evaluated the occurrence and the antimicrobial resistance profile of Arcobacter isolates recovered from different aquatic sources. Besides, we searched for Arcobacter spp. in seaweeds and the corresponding seawater samples. Bacteriological and molecular methods applied to 100 samples led to the isolation of 28 Arcobacter isolates from 27 samples. The highest prevalence was detected in rivers followed by artificial ponds, streams, well waters, and spring waters. Seaweeds contained a higher percentage of Arcobacter than the corresponding seawater samples. The isolates were identified as Arcobacter butzleri (96.4%) and Arcobacter cryaerophilus (3.6%). All the isolates showed a multi-drug resistance profile, being resistant to at least three different classes of antibiotics. Molecular analysis of genetic determinants responsible for tetracycline resistance in nine randomly chosen isolates revealed the presence of tetO and/or tetW. This work confirms the occurrence and the continuous emergence of antibiotic-resistant Arcobacter strains in environmental samples; also, the presence of quinolone-resistant Arcobacter spp. in aquatic sources used for water supply and irrigation represents a potential risk for human health.

Comparisons of voltage-gated sodium channel structures with open and closed gates and implications for state-dependent drug design

2018 ◽  
Vol 46 (6) ◽  
pp. 1567-1575 ◽  
Author(s):  
Giulia Montini ◽  
Jennifer Booker ◽  
Altin Sula ◽  
B.A. Wallace
Keyword(s):  
Drug Design ◽  
Sodium Channels ◽  
Rational Drug Design ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
State Dependent ◽  
Rational Drug ◽  
Sequence Homologies ◽  
Arcobacter Butzleri ◽  
Functional Consequences

Voltage-gated sodium channels (Navs) are responsible for the initiation of the action potential in excitable cells. Several prokaryotic sodium channels, most notably NavMs from Magnetococcus marinus and NavAb from Arcobacter butzleri, have been shown to be good models for human sodium channels based on their sequence homologies and high levels of functional similarities, including ion flux, and functional consequences of critical mutations. The complete full-length crystal structures of these prokaryotic sodium channels captured in different functional states have now revealed the molecular natures of changes associated with the gating process. These include the structures of the intracellular gate, the selectivity filter, the voltage sensors, the intra-membrane fenestrations, and the transmembrane (TM) pore. Here we have identified for the first time how changes in the fenestrations in the hydrophobic TM region associated with the opening of the intracellular gate could modulate the state-dependent ingress and binding of drugs in the TM cavity, in a way that could be exploited for rational drug design.

scholarly journals Bacteremia Caused by Arcobacter butzleri in an Immunocompromised Host

2015 ◽  
Vol 53 (4) ◽  
pp. 1448-1451 ◽  
Author(s):  
Esther Arguello ◽  
Caitlin C. Otto ◽  
Peter Mead ◽  
N. Esther Babady
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Causative Agent ◽  
Immunocompromised Host ◽  
Lymphocytic Leukemia ◽  
Watery Diarrhea ◽  
Emerging Pathogen ◽  
Content Type ◽  
Gastrointestinal Pathogens ◽  
Arcobacter Butzleri

Arcobacter butzleriis an emerging pathogen that has been implicated as the causative agent of persistent watery diarrhea. We describe a case involving a patient with chronic lymphocytic leukemia who developed invasiveA. butzleribacteremia. This case illustrates the unique challenges involved in diagnosing infections caused by emerging gastrointestinal pathogens.

Survival of Arcobacter butzleri in Apple and Pear Purees

2013 ◽  
Vol 33 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Min Hwa Lee ◽  
Changsun Choi
Keyword(s):  
Arcobacter Butzleri

scholarly journals Application of MALDI-TOF MS for the subtyping of Arcobacter butzleri strains and comparison with their MLST and PFGE types

2018 ◽  
Vol 277 ◽  
pp. 50-57 ◽  
Author(s):  
Federica Giacometti ◽  
Silvia Piva ◽  
Katleen Vranckx ◽  
Katrien De Bruyne ◽  
Ilenia Drigo ◽  
...  
Keyword(s):  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Arcobacter Butzleri ◽  
Tof Ms

Outbreak of recurrent abdominal cramps associated with Arcobacter butzleri in an Italian school.

1992 ◽  
Vol 30 (9) ◽  
pp. 2335-2337 ◽  
Author(s):  
P Vandamme ◽  
P Pugina ◽  
G Benzi ◽  
R Van Etterijck ◽  
L Vlaes ◽  
...  
Keyword(s):  
Italian School ◽  
Arcobacter Butzleri

Large genetic diversity of Arcobacter butzleri isolated from raw milk in Southern Italy

2020 ◽  
Vol 89 ◽  
pp. 103403 ◽  
Author(s):  
Caruso Marta ◽  
Normanno Giovanni ◽  
Miccolupo Angela ◽  
Capozzi Loredana ◽  
Bonerba Elisabetta ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Southern Italy ◽  
Raw Milk ◽  
Arcobacter Butzleri

scholarly journals Isolation and molecular characterization of Arcobacter butzleri and Arcobacter cryaerophilus from the pork production chain in Brazil

2018 ◽  
Vol 38 (3) ◽  
pp. 393-399 ◽  
Author(s):  
Débora D.S. Gobbi ◽  
Maria G. Spindola ◽  
Luisa Z. Moreno ◽  
Carlos E.C. Matajira ◽  
Maria G.X. Oliveira ◽  
...  
Keyword(s):  
Animal Origin ◽  
Isolation And Identification ◽  
Production Chain ◽  
Fecal Samples ◽  
Pork Production ◽  
True Incidence ◽  
Arcobacter Butzleri ◽  
Meat Markets ◽  
Human Infections

ABSTRACT: Arcobacter is an emerging zoonotic pathogen, and the major transmission routes to humans are the handling or consumption of contaminated raw/undercooked food products of animal origin, water and seafood. The isolation and identification of Arcobacter species are not routine in clinical laboratories; therefore, its true incidence in human infections may be underestimated. The present study aimed to isolate and characterize Arcobacter from carcasses and fecal samples collected at swine slaughterhouses and from meat markets in São Paulo State, Brazil. The isolates were identified using multiplex-PCR to differentiate the species and analyzed by single-enzyme amplified fragment length polymorphism (SE-AFLP). Arcobacter spp. were isolated from 73.0% of swine carcasses, 4% of fecal samples and 10% of pork samples. A. butzleri was the most prevalent species identified, followed by A. cryaerophilus. Interestingly, the carcasses presented higher frequency of A. butzleri isolation, whereas only A. cryaerophilus was isolated from fecal samples. SE-AFLP enabled the characterization of A. butzleri and A. cryaerophilus into 51 and 63 profiles, respectively. The great genetic heterogeneity observed for both species corroborates previous reports. This study confirms the necessity for a standard isolation protocol and the improvement of molecular tools to further elucidate Arcobacter epidemiology.

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